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Protein

Ras-related protein RABE1a

Gene

RABE1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in membrane trafficking from the Golgi to the plasma membrane.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 298GTPBy similarity
Nucleotide bindingi70 – 745GTPBy similarity
Nucleotide bindingi128 – 1314GTPBy similarity
Nucleotide bindingi159 – 1602GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-1445148. Translocation of GLUT4 to the plasma membrane.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABE1a
Short name:
AtRABE1a
Alternative name(s):
Ras-related protein Rab8B
Short name:
AtRab8B
Gene namesi
Name:RABE1A
Synonyms:RAB8, RAB8B
Ordered Locus Names:At3g53610
ORF Names:F4P12.310
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G53610.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • Golgi membrane Source: UniProtKB-SubCell
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Ras-related protein RABE1aPRO_0000407332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity
Lipidationi214 – 2141S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

PaxDbiO24466.
PRIDEiO24466.

Expressioni

Inductioni

By ethylene.1 Publication

Gene expression databases

GenevisibleiO24466. AT.

Interactioni

Subunit structurei

Interacts with PI5K2.1 Publication

Protein-protein interaction databases

BioGridi9846. 8 interactions.
IntActiO24466. 5 interactions.
STRINGi3702.AT3G53610.1.

Structurei

3D structure databases

ProteinModelPortaliO24466.
SMRiO24466. Positions 13-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi44 – 529Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
HOGENOMiHOG000233968.
InParanoidiO24466.
KOiK07901.
OMAiFDNIKTW.
PhylomeDBiO24466.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPPARARA DYDYLIKLLL IGDSGVGKSC LLLRFSDGSF TTSFITTIGI
60 70 80 90 100
DFKIRTIELD GKRIKLQIWD TAGQERFRTI TTAYYRGAMG ILLVYDVTDE
110 120 130 140 150
SSFNNIRNWI RNIEQHASDS VNKILVGNKA DMDESKRAVP KSKGQALADE
160 170 180 190 200
YGMKFFETSA KTNLNVEEVF FSIAKDIKQR LADTDARAEP QTIKINQSDQ
210
GAGTSQATQK SACCGT
Length:216
Mass (Da):23,939
Last modified:January 1, 1998 - v1
Checksum:i1648E45B29D4EEB6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82434 mRNA. Translation: AAB65088.1.
AL132966 Genomic DNA. Translation: CAB67668.1.
CP002686 Genomic DNA. Translation: AEE79116.1.
CP002686 Genomic DNA. Translation: AEE79117.1.
CP002686 Genomic DNA. Translation: AEE79118.1.
BT004779 mRNA. Translation: AAO44045.1.
AK228083 mRNA. Translation: BAF00042.1.
AK230120 mRNA. Translation: BAF01936.1.
AY086756 mRNA. Translation: AAM63807.1.
PIRiT45901.
RefSeqiNP_001078278.1. NM_001084809.1.
NP_190929.1. NM_115221.3.
NP_850696.1. NM_180365.3.
UniGeneiAt.10020.

Genome annotation databases

EnsemblPlantsiAT3G53610.1; AT3G53610.1; AT3G53610.
AT3G53610.2; AT3G53610.2; AT3G53610.
AT3G53610.3; AT3G53610.3; AT3G53610.
GeneIDi824529.
GrameneiAT3G53610.1; AT3G53610.1; AT3G53610.
AT3G53610.2; AT3G53610.2; AT3G53610.
AT3G53610.3; AT3G53610.3; AT3G53610.
KEGGiath:AT3G53610.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82434 mRNA. Translation: AAB65088.1.
AL132966 Genomic DNA. Translation: CAB67668.1.
CP002686 Genomic DNA. Translation: AEE79116.1.
CP002686 Genomic DNA. Translation: AEE79117.1.
CP002686 Genomic DNA. Translation: AEE79118.1.
BT004779 mRNA. Translation: AAO44045.1.
AK228083 mRNA. Translation: BAF00042.1.
AK230120 mRNA. Translation: BAF01936.1.
AY086756 mRNA. Translation: AAM63807.1.
PIRiT45901.
RefSeqiNP_001078278.1. NM_001084809.1.
NP_190929.1. NM_115221.3.
NP_850696.1. NM_180365.3.
UniGeneiAt.10020.

3D structure databases

ProteinModelPortaliO24466.
SMRiO24466. Positions 13-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9846. 8 interactions.
IntActiO24466. 5 interactions.
STRINGi3702.AT3G53610.1.

Proteomic databases

PaxDbiO24466.
PRIDEiO24466.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G53610.1; AT3G53610.1; AT3G53610.
AT3G53610.2; AT3G53610.2; AT3G53610.
AT3G53610.3; AT3G53610.3; AT3G53610.
GeneIDi824529.
GrameneiAT3G53610.1; AT3G53610.1; AT3G53610.
AT3G53610.2; AT3G53610.2; AT3G53610.
AT3G53610.3; AT3G53610.3; AT3G53610.
KEGGiath:AT3G53610.

Organism-specific databases

TAIRiAT3G53610.

Phylogenomic databases

eggNOGiKOG0078. Eukaryota.
ENOG410XPUI. LUCA.
HOGENOMiHOG000233968.
InParanoidiO24466.
KOiK07901.
OMAiFDNIKTW.
PhylomeDBiO24466.

Enzyme and pathway databases

ReactomeiR-ATH-1445148. Translocation of GLUT4 to the plasma membrane.
R-ATH-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiO24466.

Gene expression databases

GenevisibleiO24466. AT.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A new member of the rab-family from Arabidospsis."
    Bischoff F., Palme K.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Analysis of the small GTPase gene superfamily of Arabidopsis."
    Vernoud V., Horton A.C., Yang Z., Nielsen E.
    Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Ethylene regulates monomeric GTP-binding protein gene expression and activity in Arabidopsis."
    Moshkov I.E., Mur L.A., Novikova G.V., Smith A.R., Hall M.A.
    Plant Physiol. 131:1705-1717(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY ETHYLENE.
  9. "Arabidopsis Rab-E GTPases exhibit a novel interaction with a plasma-membrane phosphatidylinositol-4-phosphate 5-kinase."
    Camacho L., Smertenko A.P., Perez-Gomez J., Hussey P.J., Moore I.
    J. Cell Sci. 122:4383-4392(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PI5K2.

Entry informationi

Entry nameiRAE1A_ARATH
AccessioniPrimary (citable) accession number: O24466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 1, 1998
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.