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Protein

Linoleate 9S-lipoxygenase 2

Gene

LOX1.2

Organism
Solanum tuberosum (Potato)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure. Linoleic acid is the preferred substrate, but is also active with linolenic and arachidonic acids.PROSITE-ProRule annotation1 Publication

Catalytic activityi

Linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate.1 Publication

Cofactori

Fe cationPROSITE-ProRule annotationNote: Binds 1 Fe cation per subunit. Iron is tightly bound.PROSITE-ProRule annotation

pH dependencei

Optimum pH is 6.0.1 Publication

Pathwayi: oxylipin biosynthesis

This protein is involved in the pathway oxylipin biosynthesis, which is part of Lipid metabolism.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway oxylipin biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi522Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi527Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi713Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi717Iron; catalyticPROSITE-ProRule annotation1
Metal bindingi861Iron; via carboxylate; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

  • linoleate 13S-lipoxygenase activity Source: CACAO
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Oxylipin biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-12726
UniPathwayiUPA00382

Names & Taxonomyi

Protein namesi
Recommended name:
Linoleate 9S-lipoxygenase 2 (EC:1.13.11.58)
Alternative name(s):
Lipoxygenase 1-2
Gene namesi
Name:LOX1.2
Synonyms:LOX1, T8
OrganismiSolanum tuberosum (Potato)
Taxonomic identifieri4113 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanum
Proteomesi
  • UP000011115 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004129201 – 861Linoleate 9S-lipoxygenase 2Add BLAST861

Proteomic databases

PRIDEiO24379

Expressioni

Tissue specificityi

Highly expressed in tubers and roots. Detected in flower buds and leaves.1 Publication

Developmental stagei

Expressed in stolons and increases during early stages of tuber development.1 Publication

Inductioni

Up-regulated in roots 2 hours after jasmonate treatment and 24 hours after wounding. Not induced in the leaves.1 Publication

Gene expression databases

ExpressionAtlasiO24379 baseline and differential

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi4113.PGSC0003DMT400054145

Structurei

3D structure databases

ProteinModelPortaliO24379
SMRiO24379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 160PLATPROSITE-ProRule annotationAdd BLAST132
Domaini163 – 861LipoxygenasePROSITE-ProRule annotationAdd BLAST699

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi446 – 451Poly-Thr6

Sequence similaritiesi

Belongs to the lipoxygenase family.Curated

Phylogenomic databases

eggNOGiENOG410IH0D Eukaryota
ENOG410YN4N LUCA
InParanoidiO24379
KOiK15718

Family and domain databases

Gene3Di4.10.372.10, 1 hit
InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001246 LipOase_plant
IPR027433 Lipoxygenase_dom_3
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00468 PLTLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

O24379-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGQITSGLF GGPDDSKKLK GTVVMMNKNA LDFTDLAGSL TDKAFEFLGQ
60 70 80 90 100
TVSFQLISSV QGDPTNGLQG KHSNPAYLEN SLFTLTPLTA GSETAFGVTF
110 120 130 140 150
DWNEEFGVPG AFIIKNTHIN EFFLKSLTLE DVPNHGKVHF VCNSWVYPSF
160 170 180 190 200
RYKSDRIFFV NQPYLPSKTP ELLRKYRENE LLTLRGDGTG KREAWDRIYD
210 220 230 240 250
YDIYNDLGNP DEGKENVRTT LGGSAEYPYP RRGRTGRPPT RTDPKSESRI
260 270 280 290 300
PLILSLDIYV PRDERFGHLK MSDFLTYALK SIVQFILPEL HALFDGTPNE
310 320 330 340 350
FDSFEDVLRL YEGGIKLPQG PLFKALTAAI PLEMIRELLR TDGEGILRFP
360 370 380 390 400
TPLVIKDSKT AWRTDEEFAR EMLAGVNPVI ISRLQEFPPK SKLDPEAYGN
410 420 430 440 450
QNSTITAEHI EDKLDGLTVD EAMNNNKLFI LNHHDVLIPY LRRINTTTTK
460 470 480 490 500
TYASRTLLFL QDNGSLKPLA IELSLPHPDG DQFGVTSKVY TPSDQGVESS
510 520 530 540 550
IWQLAKAYVA VNDSGVHQLI SHWLNTHAVI EPFVIATNRQ LSVLHPIHKL
560 570 580 590 600
LYPHFRDTMN INAMARQILI NAGGVLESTV FQSKFAMEMS AVVYKDWVFP
610 620 630 640 650
DQALPADLVK RGVAVEDSSS PHGVRLLIED YPYAVDGLEI WSAIKSWVSD
660 670 680 690 700
YCSFYYGSDE EILKDNELQA WWKELREVGH GDKKNEPWWP EMERPQELID
710 720 730 740 750
SCTTIIWIAS ALHAAVNFGQ YPYAGYLPNR PTVSRRFMPE PGTPEYEELK
760 770 780 790 800
KNPDKAFLKT ITAQLQTLLG VSLIEILSRH TTDEIYLGQR ESPEWTKDKE
810 820 830 840 850
PLAAFDKFGK KLTDIEKQII QRNGDNILTN RSGPVNAPYT LLFPTSEGGL
860
TGKGIPNSVS I
Length:861
Mass (Da):97,067
Last modified:January 1, 1998 - v1
Checksum:i25783F32C69BFA26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95513 mRNA Translation: CAA64766.1
RefSeqiNP_001275357.1, NM_001288428.1
UniGeneiStu.965

Genome annotation databases

GeneIDi102602192
KEGGisot:102602192

Similar proteinsi

Entry informationi

Entry nameiLOX12_SOLTU
AccessioniPrimary (citable) accession number: O24379
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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