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O24319 (O24319_PHAVU) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential EMBL CAA04644.1
Chain28 – 459432purple acid phosphatase EMBL CAA04644.1
PRO_5000064272

Regions

Region88 – 914Sulfate 5 binding PDB 4DSY PDB 4DHL PDB 4DT2
Region92 – 932Sulfate 6 binding PDB 4DT2
Region133 – 1364Sulfate 4 binding PDB 4DT2
Region197 – 1982Sulfate 2 binding PDB 4DT2
Region197 – 1982Sulfate 9 binding PDB 4DT2
Region248 – 2514Sulfate 7 binding PDB 4DT2
Region302 – 3032Sulfate 11 binding PDB 4DSY PDB 4DHL PDB 4DT2
Region401 – 4033Sulfate 13 binding
Region409 – 4102Sulfate 14 binding PDB 4DT2

Sites

Metal binding1621Iron PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding1911Iron PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding1911Zinc PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding1941Iron PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding2281Zinc PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding3131Zinc; via tele nitrogen PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding3501Zinc; via pros nitrogen PDB 4DSY PDB 4DHL PDB 4DT2
Metal binding3521Iron; via tele nitrogen PDB 4DSY PDB 4DHL PDB 4DT2
Binding site361Sulfate 1
Binding site811Sulfate 4; via amide nitrogen PDB 4DT2
Binding site951Sulfate 5 PDB 4DSY PDB 4DHL PDB 4DT2
Binding site1101Acetate 2; via amide nitrogen PDB 4DT2
Binding site1241Sulfate 3
Binding site1241Sulfate 8; via amide nitrogen
Binding site1281Sulfate 5 PDB 4DSY PDB 4DHL PDB 4DT2
Binding site1481Sulfate 3
Binding site2901Sulfate 10
Binding site3331Sulfate 10
Binding site3761Sulfate 12; via amide nitrogen
Binding site4031Sulfate 14 PDB 4DT2
Binding site4101Sulfate 13
Binding site4101Sulfate 15

Amino acid modifications

Glycosylation1081N-linked (GlcNAc...) PDB 4DSY PDB 4DHL PDB 4DT2
Glycosylation1361N-linked (GlcNAc...) PDB 4DSY PDB 4DHL PDB 4DT2
Glycosylation1701N-linked (GlcNAc...) PDB 4DSY PDB 4DHL PDB 4DT2
Glycosylation4231N-linked (GlcNAc...) PDB 4DSY PDB 4DHL PDB 4DT2

Sequences

Sequence LengthMass (Da)Tools
O24319 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CC379B7C1AE4D21A

FASTA45952,857
        10         20         30         40         50         60 
MGVVKGLLAL ALVLNVVVVS NGGKSSNFVR KTNKNRDMPL DSDVFRVPPG YNAPQQVHIT 

        70         80         90        100        110        120 
QGDLVGRAMI ISWVTMDEPG SSAVRYWSEK NGRKRIAKGK MSTYRFFNYS SGFIHHTTIR 

       130        140        150        160        170        180 
KLKYNTKYYY EVGLRNTTRR FSFITPPQTG LDVPYTFGLI GDLGQSFDSN TTLSHYELSP 

       190        200        210        220        230        240 
KKGQTVLFVG DLSYADRYPN HDNVRWDTWG RFTERSVAYQ PWIWTAGNHE IEFAPEINET 

       250        260        270        280        290        300 
EPFKPFSYRY HVPYEASQST SPFWYSIKRA SAHIIVLSSY SAYGRGTPQY TWLKKELRKV 

       310        320        330        340        350        360 
KRSETPWLIV LMHSPLYNSY NHHFMEGEAM RTKFEAWFVK YKVDVVFAGH VHAYERSERV 

       370        380        390        400        410        420 
SNIAYKITNG LCTPVKDQSA PVYITIGDAG NYGVIDSNMI QPQPEYSAFR EASFGHGMFD 

       430        440        450 
IKNRTHAHFS WNRNQDGVAV EADSVWFFNR HWYPVDDST 

« Hide

References

[1]"Heterologous expression and characterization of recombinant purple acid phosphatase from red kidney bean."
Vogel A., Borchers T., Marcus K., Meyer H.E., Krebs B., Spener F.
Arch. Biochem. Biophys. 401:164-172(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Seed EMBL CAA04644.1.
[2]"Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics."
Feder D., Hussein W.M., Clayton D.J., Kan M.W., Schenk G., McGeary R.P., Guddat L.W.
Chem. Biol. Drug Des. 80:665-674(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 34-459 IN COMPLEX WITH ACETATE; IRON; SULFATE AND ZINC, GLYCOSYLATION AT ASN-108; ASN-136; ASN-170 AND ASN-423.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ001270 mRNA. Translation: CAA04644.1.
PIRS51031. T51097.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4DHLX-ray2.30A/B/C/D34-459[»]
4DSYX-ray2.30A/B/C/D34-459[»]
4DT2X-ray2.70A/B/C/D34-459[»]
ProteinModelPortalO24319.
SMRO24319. Positions 36-459.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameO24319_PHAVU
AccessionPrimary (citable) accession number: O24319
Entry history
Integrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)