Reviewed, UniProtKB/Swiss-Prot O24304 (FNTA_PEA)

Names and origin

Protein names

Recommended name:
    Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
    EC=2.5.1.58
    EC=2.5.1.59
Alternative name(s):
    CAAX farnesyltransferase subunit alpha
    Ras proteins prenyltransferase subunit alpha
    FTase-alpha
    Type I protein geranyl-geranyltransferase subunit alpha
      Short name=GGTase-I-alpha

Gene names

Name:

FTA

Organism

Pisum sativum (Garden pea)

Taxonomic identifier

3888 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate By similarity.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate. Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats.

Ontologies

Keywords
Domain	Repeat
Molecular function	Prenyltransferase Transferase
Gene Ontology (GO)
Biological process	protein amino acid prenylation Inferred from electronic annotation. Source: InterPro
Molecular function	CAAX-protein geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC protein farnesyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha		PRO_0000119751
Regions
	Repeat	61 – 95	35	PFTA 1
	Repeat	96 – 130	35	PFTA 2
	Repeat	132 – 166	35	PFTA 3
	Repeat	167 – 200	34	PFTA 4
	Repeat	207 – 241	35	PFTA 5

Sequences

	Sequence		Length	Mass (Da)
	O24304-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 304926628B0C48C3	FASTA	333	38,516
	10 20 30 40 50 60 MAGNIEVEED DRVPLRLRPE WSDVTPIPQD DGPSPVVPIN YSEEFSEVMD YFRAVYFAKE 70 80 90 100 110 120 LSSRALALTA EAIGLNAGNY TVWHFRRLLL ESLKVDLHVE REFVERVASG NSKNYQIWHH 130 140 150 160 170 180 RRWVAEKLGP EARNSELEFT KKILSVDAKH YHAWSHRQWV LQNLGGWEDE LSYCSELLAE 190 200 210 220 230 240 DIFNNSAWNQ RYFVITRSPV LGGLKAMRES EVLFTVEAII SYPENESSWR YLRGLFKDES 250 260 270 280 290 300 TLYVNDAQVS SLCLKILKTK SNYLFALSTL LDLSASVIQP NEDFRDAIEA LRLQILIKQD 310 320 330 SDIAITICSI LEQVDPIRVN YWVWRKSRLP QAA

References

[1]	"Protein farnesyltransferase in plants: molecular characterization and involvement in cell cycle control." Qian D., Zhou D., Ju R., Cramer C.L., Yang Z. Plant Cell 8:2381-2394(1996) [PubMed: 8989889] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Alaska. Tissue: Root tip.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U63298 mRNA. Translation: AAB62580.1.
PIR	T06516.
3D structure databases
SMR	O24304. Positions 5-331.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.58. 287. 2.5.1.59. 287.
Family and domain databases
InterPro	IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
Pfam	PF01239. PPTA. 5 hits. [Graphical view]
PROSITE	PS51147. PFTA. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FNTA_PEA

Accession

Primary (citable) accession number: O24304

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	January 1, 1998
Last modified:	February 9, 2010
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)