ID   GPX1_PEA                Reviewed;         236 AA.
AC   O24296;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 55.
DE   RecName: Full=Phospholipid hydroperoxide glutathione peroxidase, chloroplastic;
DE            Short=PHGPx;
DE            EC=1.11.1.12;
DE   Flags: Precursor;
OS   Pisum sativum (Garden pea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Fabeae; Pisum.
OX   NCBI_TaxID=3888;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Birte;
RX   MEDLINE=98345965; PubMed=9680987;
RX   DOI=10.1046/j.1365-313X.1998.00052.x;
RA   Mullineaux P.M., Karpinski S., Jimenez A., Cleary S.P., Robinson C.,
RA   Creissen G.P.;
RT   "Identification of cDNAS encoding plastid-targeted glutathione
RT   peroxidase.";
RL   Plant J. 13:375-379(1998).
CC   -!- FUNCTION: Protects cells and enzymes from oxidative damage, by
CC       catalyzing the reduction of hydrogen peroxide, lipid peroxides and
CC       organic hydroperoxide, by glutathione (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide =
CC       glutathione disulfide + lipid + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast stroma.
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; AJ000508; CAA04142.1; -; mRNA.
DR   PIR; T06462; T06462.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 2897; PsGPx01.
DR   BRENDA; 1.11.1.12; 287.
DR   GO; GO:0009570; C:chloroplast stroma; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0047066; F:phospholipid-hydroperoxide glutathione pero...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Chloroplast; Oxidoreductase; Peroxidase; Plastid; Transit peptide.
FT   TRANSIT       1     64       Chloroplast (Potential).
FT   CHAIN        65    236       Phospholipid hydroperoxide glutathione
FT                                peroxidase, chloroplastic.
FT                                /FTId=PRO_0000013087.
FT   ACT_SITE    111    111       By similarity.
SQ   SEQUENCE   236 AA;  26400 MW;  85300731A3455E5D CRC64;
     MASMAFSTTF FTPLRDFNQP RTNSTPSTSL PFTKSSIASS KSPFFQLGFS QQASSNFPIV
     PSKTRSFSVN AKAIKDKTIY DFTVKDIDKK DVSLSKFKGK VLLIVNVASR CGLTSSNYTE
     LSHLYENFKN KGLEVLAFPC NQFGMQEPGS NEEIKQFACT KFKAEFPIFD KVDVNGPFTA
     PVYQFLKSSS GGFFGDIVKW NFEKFLVDKN GKVVERYPPT TSPFQIEKDI QKLLAA
//