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Protein

Major allergen Pru av 1

Gene

PRUA1

Organism
Prunus avium (Cherry) (Cerasus avium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Pru av 1
Alternative name(s):
Allergen Pru a 1
Allergen: Pru av 1
Gene namesi
Name:PRUA1
OrganismiPrunus avium (Cherry) (Cerasus avium)
Taxonomic identifieri42229 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeAmygdaleaePrunus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE and induces a strong histamine release.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1316. Pru av 1.0101.
597. Pru av 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Major allergen Pru av 1PRO_0000154202Add
BLAST

Structurei

Secondary structure

1
160
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1412Combined sources
Helixi16 – 238Combined sources
Turni24 – 263Combined sources
Helixi27 – 348Combined sources
Turni36 – 383Combined sources
Beta strandi39 – 5012Combined sources
Beta strandi54 – 596Combined sources
Beta strandi62 – 643Combined sources
Beta strandi66 – 7510Combined sources
Turni77 – 793Combined sources
Beta strandi81 – 866Combined sources
Turni90 – 923Combined sources
Helixi93 – 953Combined sources
Beta strandi96 – 10510Combined sources
Beta strandi111 – 12313Combined sources
Helixi131 – 15424Combined sources
Turni156 – 1594Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E09NMR-A2-160[»]
1H2ONMR-A2-160[»]
ProteinModelPortaliO24248.
SMRiO24248. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO24248.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFTYESEF TSEIPPPRLF KAFVLDADNL VPKIAPQAIK HSEILEGDGG
60 70 80 90 100
PGTIKKITFG EGSQYGYVKH KIDSIDKENY SYSYTLIEGD ALGDTLEKIS
110 120 130 140 150
YETKLVASPS GGSIIKSTSH YHTKGNVEIK EEHVKAGKEK ASNLFKLIET
160
YLKGHPDAYN
Length:160
Mass (Da):17,660
Last modified:January 1, 1998 - v1
Checksum:i4CED0AF76310A893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66076 mRNA. Translation: AAC02632.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66076 mRNA. Translation: AAC02632.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1E09NMR-A2-160[»]
1H2ONMR-A2-160[»]
ProteinModelPortaliO24248.
SMRiO24248. Positions 2-160.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1316. Pru av 1.0101.
597. Pru av 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO24248.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen."
    Scheurer S., Metzner K., Haustein D., Vieths S.
    Mol. Immunol. 34:619-629(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Allergic cross-reactivity made visible. Solution structure of the major cherry allergen Pru av 1."
    Neudecker P., Schweimer K., Nerkamp J., Scheurer S., Vieths S., Sticht H., Rosch P.
    J. Biol. Chem. 276:22756-22763(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPRU1_PRUAV
AccessioniPrimary (citable) accession number: O24248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: October 14, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.