O24248 (PRU1_PRUAV) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Major allergen Pru av 1

Alternative name(s):
Allergen Pru a 1
Allergen=Pru av 1

Gene names

Name:

PRUA1

Organism

Prunus avium (Cherry)

Taxonomic identifier

42229 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Amygdaloideae › Amygdaleae › Prunus

Protein attributes

Sequence length	160 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Allergenic properties	Causes an allergic reaction in human. Binds to IgE and induces a strong histamine release.
Sequence similarities	Belongs to the BetVI family.

Ontologies

Keywords
Biological process	Plant defense
Disease	Allergen
Molecular function	Pathogenesis-related protein
Technical term	3D-structure
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 160

160

Major allergen Pru av 1

PRO_0000154202

Secondary structure

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160

Helix Strand Turn

Details...

Beta strand

3 – 14

12

Helix

16 – 23

8

Turn

24 – 26

3

Helix

27 – 34

8

Turn

36 – 38

3

Beta strand

39 – 50

12

Beta strand

54 – 59

6

Beta strand

62 – 64

3

Beta strand

66 – 75

10

Turn

77 – 79

3

Beta strand

81 – 86

6

Turn

90 – 92

3

Helix

93 – 95

3

Beta strand

96 – 105

10

Beta strand

111 – 123

13

Helix

131 – 154

24

Turn

156 – 159

4

Sequences

	Sequence		Length	Mass (Da)
	O24248 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 4CED0AF76310A893	FASTA	160	17,660
	10 20 30 40 50 60 MGVFTYESEF TSEIPPPRLF KAFVLDADNL VPKIAPQAIK HSEILEGDGG PGTIKKITFG 70 80 90 100 110 120 EGSQYGYVKH KIDSIDKENY SYSYTLIEGD ALGDTLEKIS YETKLVASPS GGSIIKSTSH 130 140 150 160 YHTKGNVEIK EEHVKAGKEK ASNLFKLIET YLKGHPDAYN

References

[1]	"Molecular cloning, expression and characterization of Pru a 1, the major cherry allergen." Scheurer S., Metzner K., Haustein D., Vieths S. Mol. Immunol. 34:619-629(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Allergic cross-reactivity made visible. Solution structure of the major cherry allergen Pru av 1." Neudecker P., Schweimer K., Nerkamp J., Scheurer S., Vieths S., Sticht H., Rosch P. J. Biol. Chem. 276:22756-22763(2001) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U66076 mRNA. Translation: AAC02632.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1E09	NMR	-	A	2-160	[»]
1H2O	NMR	-	A	2-160	[»]

ProteinModelPortal

O24248.

SMR

O24248. Positions 2-160.

ModBase

Search...

Protein family/group databases

Allergome

1316. Pru av 1.0101.
597. Pru av 1.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

3.30.530.20. 1 hit.

InterPro

IPR024949. Bet_v_I_allergen.
IPR000916. Bet_v_I_dom.
IPR023393. START-like_dom.
[Graphical view]

Pfam

PF00407. Bet_v_1. 1 hit.
[Graphical view]

PRINTS

PR00634. BETALLERGEN.

PROSITE

PS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

O24248.

Entry information

Entry name

PRU1_PRUAV

Accession

Primary (citable) accession number: O24248

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 1, 1998
Last modified:	April 3, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program