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Protein

Major allergen Pru av 1

Gene

PRUA1

Organism
Prunus avium (Cherry) (Cerasus avium)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Pathogenesis-related protein

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Pru av 1
Alternative name(s):
Allergen Pru a 1
Allergen: Pru av 1
Gene namesi
Name:PRUA1
OrganismiPrunus avium (Cherry) (Cerasus avium)
Taxonomic identifieri42229 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsRosalesRosaceaeMaloideaeAmygdaleaePrunus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Binds to IgE and induces a strong histamine release.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei1316. Pru av 1.0101.
597. Pru av 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001542021 – 160Major allergen Pru av 1Add BLAST160

Proteomic databases

PRIDEiO24248.

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 14Combined sources12
Helixi16 – 23Combined sources8
Turni24 – 26Combined sources3
Helixi27 – 34Combined sources8
Turni36 – 38Combined sources3
Beta strandi39 – 50Combined sources12
Beta strandi54 – 59Combined sources6
Beta strandi62 – 64Combined sources3
Beta strandi66 – 75Combined sources10
Turni77 – 79Combined sources3
Beta strandi81 – 86Combined sources6
Turni90 – 92Combined sources3
Helixi93 – 95Combined sources3
Beta strandi96 – 105Combined sources10
Beta strandi111 – 123Combined sources13
Helixi131 – 154Combined sources24
Turni156 – 159Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E09NMR-A2-160[»]
1H2ONMR-A2-160[»]
ProteinModelPortaliO24248.
SMRiO24248.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO24248.

Family & Domainsi

Sequence similaritiesi

Belongs to the BetVI family.Curated

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVFTYESEF TSEIPPPRLF KAFVLDADNL VPKIAPQAIK HSEILEGDGG
60 70 80 90 100
PGTIKKITFG EGSQYGYVKH KIDSIDKENY SYSYTLIEGD ALGDTLEKIS
110 120 130 140 150
YETKLVASPS GGSIIKSTSH YHTKGNVEIK EEHVKAGKEK ASNLFKLIET
160
YLKGHPDAYN
Length:160
Mass (Da):17,660
Last modified:January 1, 1998 - v1
Checksum:i4CED0AF76310A893
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66076 mRNA. Translation: AAC02632.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66076 mRNA. Translation: AAC02632.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E09NMR-A2-160[»]
1H2ONMR-A2-160[»]
ProteinModelPortaliO24248.
SMRiO24248.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1316. Pru av 1.0101.
597. Pru av 1.

Proteomic databases

PRIDEiO24248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO24248.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR000916. Bet_v_I/MLP.
IPR024949. Bet_v_I_allergen.
IPR023393. START-like_dom.
[Graphical view]
PfamiPF00407. Bet_v_1. 1 hit.
[Graphical view]
PRINTSiPR00634. BETALLERGEN.
PROSITEiPS00451. PATHOGENESIS_BETVI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRU1_PRUAV
AccessioniPrimary (citable) accession number: O24248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.