Reviewed, UniProtKB/Swiss-Prot O24241 (FPPS1_PARAR)

Names and origin

Protein names

Recommended name:
    Farnesyl pyrophosphate synthetase 1
      Short name=FPP synthetase 1
      Short name=FPS 1
Alternative name(s):
    Farnesyl diphosphate synthetase 1
Including the following 2 domains:
    1- Recommended name:
            Dimethylallyltranstransferase
              EC=2.5.1.1
    2- Recommended name:
            Geranyltranstransferase
              EC=2.5.1.10

Gene names

Name:

FPS1

Organism

Parthenium argentatum (Guayule rubber plant)

Taxonomic identifier

35935 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Parthenium

Protein attributes

Sequence length	342 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity	Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate. Geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate.
Pathway	Isoprenoid biosynthesis; farnesyl-PP biosynthesis; farnesyl-PP from geranyl-PP and isopentenyl-PP: step 1/1. Isoprenoid biosynthesis; geranyl-PP biosynthesis; geranyl-PP from dimethylallyl-PP and isopentenyl-PP: step 1/1.
Subcellular location	Cytoplasm. Note: Rubber particles.
Sequence similarities	Belongs to the FPP/GGPP synthetase family.

Ontologies

Keywords
Biological process	Cholesterol biosynthesis Isoprene biosynthesis Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Gene Ontology (GO)
Biological process	cholesterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	dimethylallyltranstransferase activity Inferred from electronic annotation. Source: EC geranyltranstransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 342	342	Farnesyl pyrophosphate synthetase 1		PRO_0000123959

Sequences

	Sequence		Length	Mass (Da)
	O24241-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: D49AA182B74ED6EA	FASTA	342	39,367
	10 20 30 40 50 60 MSSDLKSRFL QVYDTLKSEL INDPAFEFDD DSRQWVEKML DYNVPGGKLN RGLSVIDSYQ 70 80 90 100 110 120 LLKGGELTDN EIFLAAALGW CIEWLQAYFL VLDDIMDESH TRRGQPCWFR LPKVGMIAAN 130 140 150 160 170 180 DGIILRNNVP RILKKHFRGK PYYVDLLDLF NEVEFQTASG QMIDLITTLV GEKDLSKYSL 190 200 210 220 230 240 SIHRRIVQYK TAYYSFYLPV ACALLMFGED LEKHEEVKNV LVEMGTYFQV QDDYLDCFGA 250 260 270 280 290 300 PEVIGKIGTD IEDFKCSWLV VKALELSNEE QKKILHENYG KKDPSSVAKV KELYHTLNLQ 310 320 330 340 GVFEDYENTS YKKLITSIEG HPSKAVQAVL KSFLGKIYKR QK

References

[1]

"Cloning, characterization, and heterologous expression of cDNAs for farnesyl diphosphate synthase from the guayule rubber plant reveals that this prenyltransferase occurs in rubber particles." Pan Z., Herickhoff L.A., Backhaus R.A. Arch. Biochem. Biophys. 332:196-204(1996) [PubMed: 8806726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Line 11591. Tissue: Stem bark.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X82542 mRNA. Translation: CAA57892.1.
PIR	S71398.
3D structure databases
HSSP	HSSP built from PDB template 1UBY based on UniProtKB P08836.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.5.1.1. 268459. 2.5.1.10. 268459.
Family and domain databases
InterPro	IPR000092. Polyprenyl_synt. IPR008949. Terpenoid_synth. [Graphical view]
Gene3D	G3DSA:1.10.600.10. Terpenoid_synth. 1 hit.
Pfam	PF00348. polyprenyl_synt. 1 hit. [Graphical view]
PROSITE	PS00723. POLYPRENYL_SYNTHET_1. 1 hit. PS00444. POLYPRENYL_SYNTHET_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FPPS1_PARAR

Accession

Primary (citable) accession number: O24241

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)