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O24210

- PANC_ORYSJ

UniProt

O24210 - PANC_ORYSJ

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Protein

Pantoate--beta-alanine ligase

Gene

PANC

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine to form pantothenate. Essential for panthotenate biosynthesis (Probable).1 Publication

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton donorBy similarity
Binding sitei71 – 711Beta-alanineBy similarity
Binding sitei71 – 711PantoateBy similarity
Binding sitei184 – 1841PantoateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATPBy similarity
Nucleotide bindingi178 – 1814ATPBy similarity
Nucleotide bindingi215 – 2184ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. embryo development ending in seed dormancy Source: EnsemblPlants/Gramene
  2. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.1. 4460.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PANC
Ordered Locus Names:Os03g0851800, LOC_Os03g63490
ORF Names:OSJNBa0015N08.21
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 3

Organism-specific databases

GrameneiO24210.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. cytosol Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Pantoate--beta-alanine ligasePRO_0000128300Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiO24210. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO24210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiO24210.
KOiK01918.
OMAiGDGHETW.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

O24210-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPREPEVI RDKAAMRAWS RRRRAEGKTV AVVPTMGYLH QGHLSLISAA
60 70 80 90 100
AAAASADPVA IVVTIYVNPS QFAPSEDLAT YPSDFAGDLR KLASTGVVDA
110 120 130 140 150
VFNPPDLYVR GAGRRGAASG GAISCLEEAA GDGHETWVRV ERLEKGMCGA
160 170 180 190 200
SRPVFFRGVA TIVSKLFNII EPDVAVFGKK DYQQWRVICR MVRDLDFAIE
210 220 230 240 250
IIGSEIVREA DGLAMSSRNV HLSREEREKA LSISRSLVDA RTGALKGNTD
260 270 280 290 300
CKQIKNKIVQ TLTETGGQVD YVEIVEQESL VPVEQIDGPV VICVAAWFGK
310
VRLIDNIEID TRS
Length:313
Mass (Da):34,039
Last modified:May 30, 2006 - v2
Checksum:i8079519175263FDF
GO

Sequence cautioni

The sequence CAA71303.1 differs from that shown. Reason: Sequencing errors.
The sequence CAA71303.1 differs from that shown. Reason: Frameshift at several positions.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10253 mRNA. Translation: CAA71303.1. Sequence problems.
AC096688 Genomic DNA. Translation: AAO20059.1.
DP000009 Genomic DNA. Translation: ABF99935.1.
AP008209 Genomic DNA. Translation: BAF13832.1.
AK066656 mRNA. Translation: BAG90070.1.
PIRiT03924.
RefSeqiNP_001051918.1. NM_001058453.1.
UniGeneiOs.4531.

Genome annotation databases

EnsemblPlantsiOS03T0851800-01; OS03T0851800-01; OS03G0851800.
GeneIDi4334806.
KEGGiosa:4334806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y10253 mRNA. Translation: CAA71303.1 . Sequence problems.
AC096688 Genomic DNA. Translation: AAO20059.1 .
DP000009 Genomic DNA. Translation: ABF99935.1 .
AP008209 Genomic DNA. Translation: BAF13832.1 .
AK066656 mRNA. Translation: BAG90070.1 .
PIRi T03924.
RefSeqi NP_001051918.1. NM_001058453.1.
UniGenei Os.4531.

3D structure databases

ProteinModelPortali O24210.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS03T0851800-01 ; OS03T0851800-01 ; OS03G0851800 .
GeneIDi 4334806.
KEGGi osa:4334806.

Organism-specific databases

Gramenei O24210.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
InParanoidi O24210.
KOi K01918.
OMAi GDGHETW.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BRENDAi 6.3.2.1. 4460.

Gene expression databases

ExpressionAtlasi O24210. baseline.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)."
    Genschel U., Powell C.A., Abell C., Smith A.G.
    Biochem. J. 341:669-678(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Nipponbare.
    Tissue: Seedling root.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPANC_ORYSJ
AccessioniPrimary (citable) accession number: O24210
Secondary accession number(s): Q10AH8, Q851Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 30, 2006
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3