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Protein

Pantoate--beta-alanine ligase

Gene

PANC

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine to form pantothenate. Essential for panthotenate biosynthesis (Probable).1 Publication

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathway:i(R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Pantoate--beta-alanine ligase (PANC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei43 – 431Proton donorBy similarity
Binding sitei71 – 711Beta-alanineBy similarity
Binding sitei71 – 711PantoateBy similarity
Binding sitei184 – 1841PantoateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 438ATPBy similarity
Nucleotide bindingi178 – 1814ATPBy similarity
Nucleotide bindingi215 – 2184ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.1. 4460.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PANC
Ordered Locus Names:Os03g0851800, LOC_Os03g63490
ORF Names:OSJNBa0015N08.21
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
ProteomesiUP000000763 Componenti: Chromosome 3

Organism-specific databases

GrameneiO24210.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Pantoate--beta-alanine ligasePRO_0000128300Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiO24210. baseline.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi39947.LOC_Os03g63490.1.

Structurei

3D structure databases

ProteinModelPortaliO24210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiO24210.
KOiK01918.
OMAiQKDAQQF.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

O24210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPREPEVI RDKAAMRAWS RRRRAEGKTV AVVPTMGYLH QGHLSLISAA
60 70 80 90 100
AAAASADPVA IVVTIYVNPS QFAPSEDLAT YPSDFAGDLR KLASTGVVDA
110 120 130 140 150
VFNPPDLYVR GAGRRGAASG GAISCLEEAA GDGHETWVRV ERLEKGMCGA
160 170 180 190 200
SRPVFFRGVA TIVSKLFNII EPDVAVFGKK DYQQWRVICR MVRDLDFAIE
210 220 230 240 250
IIGSEIVREA DGLAMSSRNV HLSREEREKA LSISRSLVDA RTGALKGNTD
260 270 280 290 300
CKQIKNKIVQ TLTETGGQVD YVEIVEQESL VPVEQIDGPV VICVAAWFGK
310
VRLIDNIEID TRS
Length:313
Mass (Da):34,039
Last modified:May 30, 2006 - v2
Checksum:i8079519175263FDF
GO

Sequence cautioni

The sequence CAA71303.1 differs from that shown.Sequencing errors.Curated
The sequence CAA71303.1 differs from that shown. Reason: Frameshift at several positions. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10253 mRNA. Translation: CAA71303.1. Sequence problems.
AC096688 Genomic DNA. Translation: AAO20059.1.
DP000009 Genomic DNA. Translation: ABF99935.1.
AP008209 Genomic DNA. Translation: BAF13832.1.
AK066656 mRNA. Translation: BAG90070.1.
PIRiT03924.
RefSeqiNP_001051918.1. NM_001058453.1.
UniGeneiOs.4531.

Genome annotation databases

EnsemblPlantsiOS03T0851800-01; OS03T0851800-01; OS03G0851800.
GeneIDi4334806.
KEGGiosa:4334806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10253 mRNA. Translation: CAA71303.1. Sequence problems.
AC096688 Genomic DNA. Translation: AAO20059.1.
DP000009 Genomic DNA. Translation: ABF99935.1.
AP008209 Genomic DNA. Translation: BAF13832.1.
AK066656 mRNA. Translation: BAG90070.1.
PIRiT03924.
RefSeqiNP_001051918.1. NM_001058453.1.
UniGeneiOs.4531.

3D structure databases

ProteinModelPortaliO24210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g63490.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS03T0851800-01; OS03T0851800-01; OS03G0851800.
GeneIDi4334806.
KEGGiosa:4334806.

Organism-specific databases

GrameneiO24210.

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
InParanoidiO24210.
KOiK01918.
OMAiQKDAQQF.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00005.
BRENDAi6.3.2.1. 4460.

Gene expression databases

ExpressionAtlasiO24210. baseline.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)."
    Genschel U., Powell C.A., Abell C., Smith A.G.
    Biochem. J. 341:669-678(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: cv. Nipponbare.
    Tissue: Seedling root.
  2. "Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species."
    The rice chromosome 3 sequencing consortium
    Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S.
    , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S.
    Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiPANC_ORYSJ
AccessioniPrimary (citable) accession number: O24210
Secondary accession number(s): Q10AH8, Q851Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 30, 2006
Last modified: July 22, 2015
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.