O24210 (PANC_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantoate--beta-alanine ligase
EC=6.3.2.1

Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase

Gene names

Name:	PANC
Ordered Locus Names:	Os03g0851800, LOC_Os03g63490
ORF Names:	OSJNBa0015N08.21

Organism

Oryza sativa subsp. japonica (Rice) [Reference proteome]

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	313 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.
Pathway	Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Subunit structure	Homodimer Potential.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the pantothenate synthetase family.
Sequence caution	The sequence CAA71303.1 differs from that shown. Reason: Frameshift at several positions. The sequence CAA71303.1 differs from that shown. Reason: Sequencing errors.

Ontologies

Keywords
Biological process	Pantothenate biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	embryo development ending in seed dormancy Inferred from electronic annotation. Source: EnsemblPlants/Gramene pantothenate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytosol Inferred from electronic annotation. Source: EnsemblPlants/Gramene
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantoate-beta-alanine ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 313	313	Pantoate--beta-alanine ligase		PRO_0000128300

Sequences

	Sequence		Length	Mass (Da)
	O24210 [UniParc]. Last modified May 30, 2006. Version 2. Checksum: 8079519175263FDF	FASTA	313	34,039
	10 20 30 40 50 60 MAAPREPEVI RDKAAMRAWS RRRRAEGKTV AVVPTMGYLH QGHLSLISAA AAAASADPVA 70 80 90 100 110 120 IVVTIYVNPS QFAPSEDLAT YPSDFAGDLR KLASTGVVDA VFNPPDLYVR GAGRRGAASG 130 140 150 160 170 180 GAISCLEEAA GDGHETWVRV ERLEKGMCGA SRPVFFRGVA TIVSKLFNII EPDVAVFGKK 190 200 210 220 230 240 DYQQWRVICR MVRDLDFAIE IIGSEIVREA DGLAMSSRNV HLSREEREKA LSISRSLVDA 250 260 270 280 290 300 RTGALKGNTD CKQIKNKIVQ TLTETGGQVD YVEIVEQESL VPVEQIDGPV VICVAAWFGK 310 VRLIDNIEID TRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)." Genschel U., Powell C.A., Abell C., Smith A.G. Biochem. J. 341:669-678(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Nipponbare. Tissue: Seedling root.
[2]	"Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species." The rice chromosome 3 sequencing consortium Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B., Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T., Fadrosh D., Bera J., Weaver B., Jin S. , Johri S., Reardon M., Webb K., Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T., Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R., Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J., Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S., Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M., Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M., Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L., O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R., Jin W., Lee H.R., Jiang J., Jackson S. Genome Res. 15:1284-1291(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y10253 mRNA. Translation: CAA71303.1. Sequence problems. AC096688 Genomic DNA. Translation: AAO20059.1. AK066656 mRNA. No translation available.
PIR	T03924.
RefSeq	NP_001051918.1. NM_001058453.1.
UniGene	Os.4531.
3D structure databases
ProteinModelPortal	O24210.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	LOC_Os03g63490.1; LOC_Os03g63490.1; LOC_Os03g63490.
GeneID	4334806.
KEGG	dosa:Os03t0851800-01. osa:4334806.
Organism-specific databases
Gramene	O24210.
Phylogenomic databases
eggNOG	COG0414.
HOGENOM	HOG000175516.
KO	K01918.
OMA	HTIVSVF.
ProtClustDB	PLN02660.
Enzyme and pathway databases
BRENDA	6.3.2.1. 4460.
UniPathway	UPA00028; UER00005.
Gene expression databases
ArrayExpress	O24210.
Family and domain databases
Gene3D	3.40.50.620. 1 hit.
InterPro	IPR003721. Pantoate_ligase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
PANTHER	PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfam	PF02569. Pantoate_ligase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00018. panC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PANC_ORYSJ

Accession

Primary (citable) accession number: O24210
Secondary accession number(s): Q851Y0

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 30, 2006
Last modified:	April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program