ID   BADH_ORYSJ              Reviewed;         505 AA.
AC   O24174; Q7F9Q3;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 60.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   OrderedLocusNames=Os04g0464200, LOC_Os04g39020;
GN   ORFNames=OSJNBa0060P14.8;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade;
OC   Ehrhartoideae; Oryzeae; Oryza.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=97336302; PubMed=9193078;
RX   DOI=10.1046/j.1365-313X.1997.11051115.x;
RA   Nakamura T., Yokota S., Muramoto Y., Tsutsui K., Oguri Y., Fukui K.,
RA   Takabe T.;
RT   "Expression of a betaine aldehyde dehydrogenase gene in rice, a
RT   glycinebetaine nonaccumulator, and possible localization of its
RT   protein in peroxisomes.";
RL   Plant J. 11:1115-1120(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22337377; PubMed=12447439; DOI=10.1038/nature01183;
RA   Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J.,
RA   Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y.,
RA   Weng Q., Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D.,
RA   Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J.,
RA   Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H.,
RA   Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y.,
RA   Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W.,
RA   Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W.,
RA   Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y.,
RA   Han B.;
RT   "Sequence and analysis of rice chromosome 4.";
RL   Nature 420:316-320(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   MEDLINE=22752273; PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Peroxisome.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AB001348; BAA21098.1; -; Genomic_DNA.
DR   EMBL; AL663017; CAD41035.1; -; Genomic_DNA.
DR   EMBL; AK103582; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T03394; T03394.
DR   RefSeq; NP_001053016.1; -.
DR   UniGene; Os.26839; -.
DR   HSSP; P05091; 1O04.
DR   GeneID; 4336081; -.
DR   KEGG; osa:4336081; -.
DR   Gramene; O24174; -.
DR   GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   2: Evidence at transcript level;
KW   NAD; Oxidoreductase; Peroxisome.
FT   CHAIN         1    505       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_0000056530.
FT   NP_BIND     240    245       NAD (By similarity).
FT   MOTIF       503    505       Microbody targeting signal (Potential).
FT   ACT_SITE    262    262       By similarity.
FT   ACT_SITE    296    296       By similarity.
SQ   SEQUENCE   505 AA;  54648 MW;  85EFA42B059A8081 CRC64;
     MAAPSAIPRR GLFIGGGWRE PSLGRRLPVV NPATEATIGD IPAATAEDVE LAVSAARDAF
     GRDGGRHWSR APGAVRAKYL KAIAAKIKDK KSYLALLETL DSGKPLDEAA GDMEDVAACF
     EYYADLAEAL DGKQRAPISL PMENFESYVL KEPIGVVGLI TPWNYPLLMA TWKVAPALAA
     GCTAVLKPSE LASLTCLELG GICAEIGLPP GVLNIITGLG TEAGAPLASH PHVDKIAFTG
     STETGKRIMI TASQMVKPVS LELGGKSPLI VFDDVDIDKA VEWAMFGCFA NAGQVCSATS
     RLLLHEKIAK RFLDRLVAWA KSIKISDPLE EGCRLGSVVS EGQYQKIMKF ISTARCEGAT
     ILYGGARPQH LKRGFFIEPT IITNVSTSMQ IWREEVFGPV ICVKEFRTER EAVELANDTH
     YGLAGAVISN DLERCERISK AIQSGIVWIN CSQPCFVQAP WGGNKRSGFG RELGQWGLDN
     YLSVKQVTKY CSDEPYGWYR PPSKL
//