Reviewed, UniProtKB/Swiss-Prot O24174 (BADH_ORYSJ)

Names and origin

Protein names

Recommended name:
    Betaine aldehyde dehydrogenase
      Short name=BADH
    EC=1.2.1.8

Gene names

Ordered Locus Names:	Os04g0464200, LOC_Os04g39020
ORF Names:	OSJNBa0060P14.8

Organism

Oryza sativa subsp. japonica (Rice)

Taxonomic identifier

39947 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1.
Subunit structure	Homodimer By similarity.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Cellular component	Peroxisome
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	Betaine aldehyde dehydrogenase		PRO_0000056530
Regions
	Nucleotide binding	240 – 245	6	NAD By similarity
	Motif	503 – 505	3	Microbody targeting signal Potential
Sites
	Active site	262	1	By similarity
	Active site	296	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O24174-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 85EFA42B059A8081	FASTA	505	54,648
	10 20 30 40 50 60 MAAPSAIPRR GLFIGGGWRE PSLGRRLPVV NPATEATIGD IPAATAEDVE LAVSAARDAF 70 80 90 100 110 120 GRDGGRHWSR APGAVRAKYL KAIAAKIKDK KSYLALLETL DSGKPLDEAA GDMEDVAACF 130 140 150 160 170 180 EYYADLAEAL DGKQRAPISL PMENFESYVL KEPIGVVGLI TPWNYPLLMA TWKVAPALAA 190 200 210 220 230 240 GCTAVLKPSE LASLTCLELG GICAEIGLPP GVLNIITGLG TEAGAPLASH PHVDKIAFTG 250 260 270 280 290 300 STETGKRIMI TASQMVKPVS LELGGKSPLI VFDDVDIDKA VEWAMFGCFA NAGQVCSATS 310 320 330 340 350 360 RLLLHEKIAK RFLDRLVAWA KSIKISDPLE EGCRLGSVVS EGQYQKIMKF ISTARCEGAT 370 380 390 400 410 420 ILYGGARPQH LKRGFFIEPT IITNVSTSMQ IWREEVFGPV ICVKEFRTER EAVELANDTH 430 440 450 460 470 480 YGLAGAVISN DLERCERISK AIQSGIVWIN CSQPCFVQAP WGGNKRSGFG RELGQWGLDN 490 500 YLSVKQVTKY CSDEPYGWYR PPSKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a betaine aldehyde dehydrogenase gene in rice, a glycinebetaine nonaccumulator, and possible localization of its protein in peroxisomes." Nakamura T., Yokota S., Muramoto Y., Tsutsui K., Oguri Y., Fukui K., Takabe T. Plant J. 11:1115-1120(1997) [PubMed: 9193078] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Nipponbare.
[2]	"Sequence and analysis of rice chromosome 4." Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y., Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q., Zhang L. , Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T., Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R., Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G., Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C., Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J., Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J., Li J., Hong G., Xue Y., Han B. Nature 420:316-320(2002) [PubMed: 12447439] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Nipponbare.
[3]	"Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice." The rice full-length cDNA consortium Science 301:376-379(2003) [PubMed: 12869764] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Nipponbare.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB001348 Genomic DNA. Translation: BAA21098.1. AL663017 Genomic DNA. Translation: CAD41035.1. AK103582 mRNA. No translation available.
PIR	T03394.
RefSeq	NP_001053016.1.
UniGene	Os.26839
3D structure databases
HSSP	HSSP built from PDB template 1O04 based on UniProtKB P05091.
ModBase	Search...
Genome annotation databases
GeneID	4336081.
KEGG	osa:4336081.
Organism-specific databases
Gramene	O24174.
Family and domain databases
InterPro	IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BADH_ORYSJ

Accession

Primary (citable) accession number: O24174
Secondary accession number(s): Q7F9Q3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)