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Protein

Major pollen allergen Ole e 6

Gene

OLE6

Organism
Olea europaea (Common olive)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Major pollen allergen Ole e 6
Alternative name(s):
Allergen: Ole e 6
Gene namesi
Name:OLE6
OrganismiOlea europaea (Common olive)
Taxonomic identifieri4146 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesOleaceaeOleeaeOlea

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Major allergen from olive pollen.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3387. Ole e 6.0101.
494. Ole e 6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 5050Major pollen allergen Ole e 6PRO_0000064562Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi8 ↔ 341 Publication
Disulfide bondi12 ↔ 301 Publication
Disulfide bondi16 ↔ 261 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed in pollen.1 Publication

Structurei

Secondary structure

1
50
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 1715Combined sources
Turni18 – 203Combined sources
Helixi23 – 3311Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SS3NMR-A1-50[»]
DisProtiDP00580.
ProteinModelPortaliO24172.
SMRiO24172. Positions 1-50.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO24172.

Family & Domainsi

Family and domain databases

Gene3Di1.10.287.720. 1 hit.
InterProiIPR015333. Pollen_allergen_ole-e-6.
[Graphical view]
PfamiPF09253. Ole-e-6. 1 hit.
[Graphical view]
SUPFAMiSSF111388. SSF111388. 1 hit.

Sequencei

Sequence statusi: Complete.

O24172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DEAQFKECYD TCHKECSDKG NGFTFCEMKC DTDCSVKDVK EKLENYKPKN
Length:50
Mass (Da):5,833
Last modified:January 1, 1998 - v1
Checksum:iDD770D3612933FB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86342 mRNA. Translation: AAB66909.1.
AY172112 Genomic DNA. Translation: AAO33896.1.
AY221958 mRNA. Translation: AAO34670.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86342 mRNA. Translation: AAB66909.1.
AY172112 Genomic DNA. Translation: AAO33896.1.
AY221958 mRNA. Translation: AAO34670.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1SS3NMR-A1-50[»]
DisProtiDP00580.
ProteinModelPortaliO24172.
SMRiO24172. Positions 1-50.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3387. Ole e 6.0101.
494. Ole e 6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiO24172.

Family and domain databases

Gene3Di1.10.287.720. 1 hit.
InterProiIPR015333. Pollen_allergen_ole-e-6.
[Graphical view]
PfamiPF09253. Ole-e-6. 1 hit.
[Graphical view]
SUPFAMiSSF111388. SSF111388. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Purification, amino acid sequence and immunological characterization of Ole e 6, a cysteine-enriched allergen from olive tree pollen."
    Batanero E., Ledesma A., Villalba M., Rodriguez R.
    FEBS Lett. 410:293-296(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 1-24, TISSUE SPECIFICITY, ALLERGENICITY.
    Tissue: Pollen.
  2. "Temporal and spatial gene expression of Ole e 6 allergen in olive (Olea europaea L.) pollen."
    Hamman Khalifa A., Alche J., Rodriguez Garcia M.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-50.
    Tissue: Mesocarp.
  3. Hamman Khalifa A., Alche J., Rodriguez Garcia M.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-50.
  4. "Profiling of hydrophilic proteins from Olea europaea olive pollen by MALDI TOF mass spectrometry."
    Napoli A., Aiello D., Di Donna L., Sajjad A., Perri E., Sindona G.
    Anal. Chem. 78:3434-3443(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  5. Cited for: REVIEW, NOMENCLATURE.
  6. "NMR solution structure of Ole e 6, a major allergen from olive tree pollen."
    Trevino M.A., Garcia-Mayoral M.F., Barral P., Villalba M., Santoro J., Rico M., Rodriguez R., Bruix M.
    J. Biol. Chem. 279:39035-39041(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, DISULFIDE BONDS.

Entry informationi

Entry nameiALL6_OLEEU
AccessioniPrimary (citable) accession number: O24172
Secondary accession number(s): Q5DTB8, Q84UC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 1, 1998
Last modified: December 9, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.