O24170 (ALL2B_OLEEU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Profilin-2

Alternative name(s):
Pollen allergen Ole e 2
Allergen=Ole e 2

Gene names

Name:

PRO2

Organism

Olea europaea (Common olive)

Taxonomic identifier

4146 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Lamiales › Oleaceae › Oleeae › Olea

Protein attributes

Sequence length	134 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Polymorphism	Several isoforms of the allergen exist due to polymorphism.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 134	133	Profilin-2		PRO_0000199657

Sequences

	Sequence		Length	Mass (Da)
	O24170 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: CDCB8C98917DC2DA	FASTA	134	14,427
	10 20 30 40 50 60 MSWQAYVDDH LMCDIEGHEG HRLTAAAIVG HDGSVWAQSA TFPQFKPEEM NGIMTDFNEP 70 80 90 100 110 120 GHLAPTGLHL GGTKYMVIQG EAGAVIRGKK GSGGITIKKT GQALVFGIYE EPVTPGQCNM 130 VVERLGDYLL EQGL

References

[1]	"Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen." Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R. J. Allergy Clin. Immunol. 100:365-372(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pollen.
[2]	"Analysis of olive allergens." Esteve C., Montealegre C., Marina M.L., Garcia M.C. Talanta 92:1-14(2012) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW, NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y12429 mRNA. Translation: CAA73039.1.
3D structure databases
ProteinModelPortal	O24170.
SMR	O24170. Positions 2-134.
ModBase	Search...
Protein family/group databases
Allergome	3383. Ole e 2.0101. 490. Ole e 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALL2B_OLEEU

Accession

Primary (citable) accession number: O24170

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	May 1, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program