Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O24170

- PROFB_OLEEU

UniProt

O24170 - PROFB_OLEEU

Protein

Profilin-2

Gene

PRO2

Organism
Olea europaea (Common olive)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.By similarity

    GO - Biological processi

    1. actin cytoskeleton organization Source: InterPro

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Profilin-2
    Alternative name(s):
    Pollen allergen Ole e 2
    Allergen: Ole e 2
    Gene namesi
    Name:PRO2
    OrganismiOlea europaea (Common olive)
    Taxonomic identifieri4146 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesOleaceaeOleeaeOlea

    Subcellular locationi

    Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-KW
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei3383. Ole e 2.0101.
    490. Ole e 2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 134133Profilin-2PRO_0000199657Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi13 ↔ 1181 Publication
    Modified residuei114 – 1141PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated by MAP kinases.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Interactioni

    Subunit structurei

    Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

    Structurei

    3D structure databases

    ProteinModelPortaliO24170.
    SMRiO24170. Positions 2-134.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi84 – 10017Involved in PIP2 interactionAdd
    BLAST

    Sequence similaritiesi

    Belongs to the profilin family.Curated

    Family and domain databases

    InterProiIPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view]
    PANTHERiPTHR11604. PTHR11604. 1 hit.
    PfamiPF00235. Profilin. 1 hit.
    [Graphical view]
    PRINTSiPR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTiSM00392. PROF. 1 hit.
    [Graphical view]
    SUPFAMiSSF55770. SSF55770. 1 hit.
    PROSITEiPS00414. PROFILIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O24170-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWQAYVDDH LMCDIEGHEG HRLTAAAIVG HDGSVWAQSA TFPQFKPEEM    50
    NGIMTDFNEP GHLAPTGLHL GGTKYMVIQG EAGAVIRGKK GSGGITIKKT 100
    GQALVFGIYE EPVTPGQCNM VVERLGDYLL EQGL 134
    Length:134
    Mass (Da):14,427
    Last modified:January 1, 1998 - v1
    Checksum:iCDCB8C98917DC2DA
    GO

    Polymorphismi

    Several isoforms of the allergen exist due to polymorphism.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12429 mRNA. Translation: CAA73039.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y12429 mRNA. Translation: CAA73039.1 .

    3D structure databases

    ProteinModelPortali O24170.
    SMRi O24170. Positions 2-134.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 3383. Ole e 2.0101.
    490. Ole e 2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR027310. Profilin_CS.
    IPR005455. Profilin_eukaryotes/bac.
    [Graphical view ]
    PANTHERi PTHR11604. PTHR11604. 1 hit.
    Pfami PF00235. Profilin. 1 hit.
    [Graphical view ]
    PRINTSi PR00392. PROFILIN.
    PR01640. PROFILINPLNT.
    SMARTi SM00392. PROF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55770. SSF55770. 1 hit.
    PROSITEi PS00414. PROFILIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen."
      Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
      J. Allergy Clin. Immunol. 100:365-372(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pollen.
    2. "Characterization of profilin polymorphism in pollen with a focus on multifunctionality."
      Jimenez-Lopez J.C., Morales S., Castro A.J., Volkmann D., Rodriguez-Garcia M.I., Alche Jde D.
      PLoS ONE 7:E30878-E30878(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    3. "Analysis of the effects of polymorphism on pollen profilin structural functionality and the generation of conformational, T- and B-cell epitopes."
      Jimenez-Lopez J.C., Rodriguez-Garcia M.I., Alche J.D.
      PLoS ONE 8:E76066-E76066(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING, DISULFIDE BOND.
    4. Cited for: REVIEW, NOMENCLATURE.

    Entry informationi

    Entry nameiPROFB_OLEEU
    AccessioniPrimary (citable) accession number: O24170
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.1 Publication

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3