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O24170 (PROFB_OLEEU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Profilin-2
Alternative name(s):
Pollen allergen Ole e 2
Allergen=Ole e 2
Gene names
Name:PRO2
OrganismOlea europaea (Common olive)
Taxonomic identifier4146 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesOleaceaeOleeaeOlea

Protein attributes

Sequence length134 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.

Subunit structure

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Subcellular location

Cytoplasmcytoskeleton By similarity.

Post-translational modification

Phosphorylated by MAP kinases By similarity.

Polymorphism

Several isoforms of the allergen exist due to polymorphism.

Allergenic properties

Causes an allergic reaction in human.

Miscellaneous

The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients (Ref.3).

Sequence similarities

Belongs to the profilin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DiseaseAllergen
   LigandActin-binding
   PTMDisulfide bond
Phosphoprotein
Gene Ontology (GO)
   Biological_processactin cytoskeleton organization

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 134133Profilin-2
PRO_0000199657

Regions

Motif84 – 10017Involved in PIP2 interaction

Amino acid modifications

Modified residue1141Phosphothreonine By similarity
Disulfide bond13 ↔ 118 Probable

Sequences

Sequence LengthMass (Da)Tools
O24170 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: CDCB8C98917DC2DA

FASTA13414,427
        10         20         30         40         50         60 
MSWQAYVDDH LMCDIEGHEG HRLTAAAIVG HDGSVWAQSA TFPQFKPEEM NGIMTDFNEP 

        70         80         90        100        110        120 
GHLAPTGLHL GGTKYMVIQG EAGAVIRGKK GSGGITIKKT GQALVFGIYE EPVTPGQCNM 

       130 
VVERLGDYLL EQGL 

« Hide

References

[1]"Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen."
Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
J. Allergy Clin. Immunol. 100:365-372(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pollen.
[2]"Characterization of profilin polymorphism in pollen with a focus on multifunctionality."
Jimenez-Lopez J.C., Morales S., Castro A.J., Volkmann D., Rodriguez-Garcia M.I., Alche Jde D.
PLoS ONE 7:E30878-E30878(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: POLYMORPHISM.
[3]"Analysis of the effects of polymorphism on pollen profilin structural functionality and the generation of conformational, T- and B-cell epitopes."
Jimenez-Lopez J.C., Rodriguez-Garcia M.I., Alche J.D.
PLoS ONE 8:E76066-E76066(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING, DISULFIDE BOND.
[4]"Analysis of olive allergens."
Esteve C., Montealegre C., Marina M.L., Garcia M.C.
Talanta 92:1-14(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y12429 mRNA. Translation: CAA73039.1.

3D structure databases

ProteinModelPortalO24170.
SMRO24170. Positions 2-134.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome3383. Ole e 2.0101.
490. Ole e 2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR027310. Profilin_CS.
IPR005455. Profilin_eukaryotes/bac.
[Graphical view]
PANTHERPTHR11604. PTHR11604. 1 hit.
PfamPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMSSF55770. SSF55770. 1 hit.
PROSITEPS00414. PROFILIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROFB_OLEEU
AccessionPrimary (citable) accession number: O24170
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries