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O24169

- PROFA_OLEEU

UniProt

O24169 - PROFA_OLEEU

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Protein

Profilin-1

Gene

PRO1

Organism
Olea europaea (Common olive)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton organization Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-1
Alternative name(s):
Pollen allergen Ole e 2
Allergen: Ole e 2
Gene namesi
Name:PRO1
OrganismiOlea europaea (Common olive)
Taxonomic identifieri4146 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesOleaceaeOleeaeOlea

Subcellular locationi

Cytoplasmcytoskeleton By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. cytoskeleton Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3383. Ole e 2.0101.
490. Ole e 2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 134133Profilin-1PRO_0000199656Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi13 ↔ 1181 Publication
Modified residuei114 – 1141PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

Structurei

3D structure databases

ProteinModelPortaliO24169.
SMRiO24169. Positions 2-134.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi84 – 10017Involved in PIP2 interactionAdd
BLAST

Sequence similaritiesi

Belongs to the profilin family.Curated

Family and domain databases

InterProiIPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view]
PANTHERiPTHR11604. PTHR11604. 1 hit.
PfamiPF00235. Profilin. 1 hit.
[Graphical view]
PRINTSiPR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTiSM00392. PROF. 1 hit.
[Graphical view]
SUPFAMiSSF55770. SSF55770. 1 hit.
PROSITEiPS00414. PROFILIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24169 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWQAYVDDH LMCDIEGHED HRLTAAAIVG HDGSVWAQSA TFPQFKPEEM
60 70 80 90 100
NGIMTDFNEP GHLAPTGLHL GGTKYMVIQG EAGAVIRGKK GSGGITIKKT
110 120 130
GQALVFGIYE EPVTPGQCNM VVERLGDYLV EQGM
Length:134
Mass (Da):14,489
Last modified:January 1, 1998 - v1
Checksum:i6F7B8DD1A246AF6C
GO

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12425 mRNA. Translation: CAA73035.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y12425 mRNA. Translation: CAA73035.1 .

3D structure databases

ProteinModelPortali O24169.
SMRi O24169. Positions 2-134.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 3383. Ole e 2.0101.
490. Ole e 2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR005455. PFN.
IPR027310. Profilin_CS.
[Graphical view ]
PANTHERi PTHR11604. PTHR11604. 1 hit.
Pfami PF00235. Profilin. 1 hit.
[Graphical view ]
PRINTSi PR00392. PROFILIN.
PR01640. PROFILINPLNT.
SMARTi SM00392. PROF. 1 hit.
[Graphical view ]
SUPFAMi SSF55770. SSF55770. 1 hit.
PROSITEi PS00414. PROFILIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of the panallergen profilin and the major allergen (Ole e 1) from olive tree pollen."
    Asturias J.A., Arilla M.C., Gomez-Bayon N., Martinez J., Martinez A., Palacios R.
    J. Allergy Clin. Immunol. 100:365-372(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALLERGEN.
    Tissue: Pollen.
  2. "Characterization of profilin polymorphism in pollen with a focus on multifunctionality."
    Jimenez-Lopez J.C., Morales S., Castro A.J., Volkmann D., Rodriguez-Garcia M.I., Alche Jde D.
    PLoS ONE 7:E30878-E30878(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.
  3. "Analysis of the effects of polymorphism on pollen profilin structural functionality and the generation of conformational, T- and B-cell epitopes."
    Jimenez-Lopez J.C., Rodriguez-Garcia M.I., Alche J.D.
    PLoS ONE 8:E76066-E76066(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING, DISULFIDE BOND.
  4. Cited for: REVIEW, NOMENCLATURE.

Entry informationi

Entry nameiPROFA_OLEEU
AccessioniPrimary (citable) accession number: O24169
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The variability of the residues taking part of IgE-binding epitopes might be responsible of the difference in cross-reactivity among olive pollen cultivars, and between distantly related pollen species, leading to a variable range of allergy reactions among atopic patients.1 Publication

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3