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O24163

- PPOC_TOBAC

UniProt

O24163 - PPOC_TOBAC

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Protein
Protoporphyrinogen oxidase, chloroplastic
Gene
PPXI
Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.1 Publication

Catalytic activityi

Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

Cofactori

Binds 1 FAD per subunit By similarity.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 836FAD By similarity
Nucleotide bindingi101 – 1022FAD By similarity
Nucleotide bindingi123 – 1264FAD By similarity
Nucleotide bindingi522 – 5243FAD By similarity

GO - Molecular functioni

  1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
  2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Chlorophyll biosynthesis, Heme biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-11760.
BRENDAi1.3.3.4. 3645.
UniPathwayiUPA00251; UER00324.
UPA00668.

Names & Taxonomyi

Protein namesi
Recommended name:
Protoporphyrinogen oxidase, chloroplastic (EC:1.3.3.4)
Short name:
PPO
Alternative name(s):
Protoporphyrinogen IX oxidase isozyme I
Short name:
PPO I
Short name:
PPX I
Gene namesi
Name:PPXI
OrganismiNicotiana tabacum (Common tobacco)
Taxonomic identifieri4097 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

Subcellular locationi

Plastidchloroplast 1 Publication

GO - Cellular componenti

  1. chloroplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5050Chloroplast Reviewed prediction
Add
BLAST
Chaini51 – 548498Protoporphyrinogen oxidase, chloroplastic
PRO_0000013326Add
BLAST

Expressioni

Developmental stagei

Expressed in expanding premature leaves. Decreased expression in oldest leaves. Expressed at very low level in roots.1 Publication

Inductioni

Oscillating expression during diurnal growth. Maximal expression in the dark period.1 Publication

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliO24163.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Family and domain databases

Gene3Di3.90.660.20. 1 hit.
InterProiIPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view]
PfamiPF01593. Amino_oxidase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24163-1 [UniParc]FASTAAdd to Basket

« Hide

MTTTPIANHP NIFTHQSSSS PLAFLNRTSF IPFSSISKRN SVNCNGWRTR    50
CSVAKDYTVP SSAVDGGPAA ELDCVIVGAG ISGLCIAQVM SANYPNLMVT 100
EARDRAGGNI TTVERDGYLW EEGPNSFQPS DPMLTMAVDC GLKDDLVLGD 150
PNAPRFVLWK GKLRPVPSKL TDLAFFDLMS IPGKLRAGFG AIGLRPSPPG 200
HEESVEQFVR RNLGGEVFER LIEPFCSGVY AGDPSKLSMK AAFGKVWKLE 250
ETGGSIIGGT FKAIKERSST PKAPRDPRLP KPKGQTVGSF RKGLRMLPDA 300
ISARLGSKLK LSWKLSSITK SEKGGYHLTY ETPEGVVSLQ SRSIVMTVPS 350
YVASNILRPL SVAAADALSN FYYPPVGAVT ITYPQEAIRD ERLVDGELKG 400
FGQLHPRTQG VETLGTIYSS SLFPNRAPKG RVLLLNYIGG AKNPEILSKT 450
ESQLVEVVDR DLRKMLIKPK AQDPLVVGVR VWPQAIPQFL VGHLDTLSTA 500
KAAMNDNGLE GLFLGGNYVS GVALGRCVEG AYEVASEVTG FLSRYAYK 548
Length:548
Mass (Da):59,230
Last modified:January 1, 1998 - v1
Checksum:i66892E78FB8A3E30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13465 mRNA. Translation: CAA73865.1.
PIRiT04058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y13465 mRNA. Translation: CAA73865.1 .
PIRi T04058.

3D structure databases

ProteinModelPortali O24163.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00324 .
UPA00668 .
BioCyci MetaCyc:MONOMER-11760.
BRENDAi 1.3.3.4. 3645.

Family and domain databases

Gene3Di 3.90.660.20. 1 hit.
InterProi IPR002937. Amino_oxidase.
IPR027418. PPOX_C.
IPR004572. Protoporphyrinogen_oxidase.
[Graphical view ]
Pfami PF01593. Amino_oxidase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of a plastidal and a mitochondrial isoform of tobacco protoporphyrinogen IX oxidase."
    Lermontova I., Kruse E., Mock H.-P., Grimm B.
    Proc. Natl. Acad. Sci. U.S.A. 94:8895-8900(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, SUBCELLULAR LOCATION.
    Strain: cv. SR1.

Entry informationi

Entry nameiPPOC_TOBAC
AccessioniPrimary (citable) accession number: O24163
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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