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O24163

- PPOC_TOBAC

UniProt

O24163 - PPOC_TOBAC

Protein

Protoporphyrinogen oxidase, chloroplastic

Gene

PPXI

Organism
Nicotiana tabacum (Common tobacco)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.1 Publication

    Catalytic activityi

    Protoporphyrinogen-IX + 3 O2 = protoporphyrin-IX + 3 H2O2.

    Cofactori

    Binds 1 FAD per subunit.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 836FADBy similarity
    Nucleotide bindingi101 – 1022FADBy similarity
    Nucleotide bindingi123 – 1264FADBy similarity
    Nucleotide bindingi522 – 5243FADBy similarity

    GO - Molecular functioni

    1. oxygen-dependent protoporphyrinogen oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. chlorophyll biosynthetic process Source: UniProtKB-UniPathway
    2. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Chlorophyll biosynthesis, Heme biosynthesis, Porphyrin biosynthesis

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-11760.
    BRENDAi1.3.3.4. 3645.
    UniPathwayiUPA00251; UER00324.
    UPA00668.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protoporphyrinogen oxidase, chloroplastic (EC:1.3.3.4)
    Short name:
    PPO
    Alternative name(s):
    Protoporphyrinogen IX oxidase isozyme I
    Short name:
    PPO I
    Short name:
    PPX I
    Gene namesi
    Name:PPXI
    OrganismiNicotiana tabacum (Common tobacco)
    Taxonomic identifieri4097 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeNicotianoideaeNicotianeaeNicotiana

    Subcellular locationi

    Plastidchloroplast 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chloroplast, Plastid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5050ChloroplastSequence AnalysisAdd
    BLAST
    Chaini51 – 548498Protoporphyrinogen oxidase, chloroplasticPRO_0000013326Add
    BLAST

    Expressioni

    Developmental stagei

    Expressed in expanding premature leaves. Decreased expression in oldest leaves. Expressed at very low level in roots.1 Publication

    Inductioni

    Oscillating expression during diurnal growth. Maximal expression in the dark period.1 Publication

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliO24163.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protoporphyrinogen oxidase family.Curated

    Keywords - Domaini

    Transit peptide

    Family and domain databases

    Gene3Di3.90.660.20. 1 hit.
    InterProiIPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view]
    PfamiPF01593. Amino_oxidase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00562. proto_IX_ox. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O24163-1 [UniParc]FASTAAdd to Basket

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    MTTTPIANHP NIFTHQSSSS PLAFLNRTSF IPFSSISKRN SVNCNGWRTR    50
    CSVAKDYTVP SSAVDGGPAA ELDCVIVGAG ISGLCIAQVM SANYPNLMVT 100
    EARDRAGGNI TTVERDGYLW EEGPNSFQPS DPMLTMAVDC GLKDDLVLGD 150
    PNAPRFVLWK GKLRPVPSKL TDLAFFDLMS IPGKLRAGFG AIGLRPSPPG 200
    HEESVEQFVR RNLGGEVFER LIEPFCSGVY AGDPSKLSMK AAFGKVWKLE 250
    ETGGSIIGGT FKAIKERSST PKAPRDPRLP KPKGQTVGSF RKGLRMLPDA 300
    ISARLGSKLK LSWKLSSITK SEKGGYHLTY ETPEGVVSLQ SRSIVMTVPS 350
    YVASNILRPL SVAAADALSN FYYPPVGAVT ITYPQEAIRD ERLVDGELKG 400
    FGQLHPRTQG VETLGTIYSS SLFPNRAPKG RVLLLNYIGG AKNPEILSKT 450
    ESQLVEVVDR DLRKMLIKPK AQDPLVVGVR VWPQAIPQFL VGHLDTLSTA 500
    KAAMNDNGLE GLFLGGNYVS GVALGRCVEG AYEVASEVTG FLSRYAYK 548
    Length:548
    Mass (Da):59,230
    Last modified:January 1, 1998 - v1
    Checksum:i66892E78FB8A3E30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13465 mRNA. Translation: CAA73865.1.
    PIRiT04058.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y13465 mRNA. Translation: CAA73865.1 .
    PIRi T04058.

    3D structure databases

    ProteinModelPortali O24163.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00324 .
    UPA00668 .
    BioCyci MetaCyc:MONOMER-11760.
    BRENDAi 1.3.3.4. 3645.

    Family and domain databases

    Gene3Di 3.90.660.20. 1 hit.
    InterProi IPR002937. Amino_oxidase.
    IPR027418. PPOX_C.
    IPR004572. Protoporphyrinogen_oxidase.
    [Graphical view ]
    Pfami PF01593. Amino_oxidase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00562. proto_IX_ox. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a plastidal and a mitochondrial isoform of tobacco protoporphyrinogen IX oxidase."
      Lermontova I., Kruse E., Mock H.-P., Grimm B.
      Proc. Natl. Acad. Sci. U.S.A. 94:8895-8900(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, SUBCELLULAR LOCATION.
      Strain: cv. SR1.

    Entry informationi

    Entry nameiPPOC_TOBAC
    AccessioniPrimary (citable) accession number: O24163
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3