Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

O24035

- PANC_LOTJA

UniProt

O24035 - PANC_LOTJA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Pantoate--beta-alanine ligase

Gene

PANC

Organism
Lotus japonicus (Lotus corniculatus var. japonicus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

pH dependencei

Optimum pH is 7.8. Activity decreases sharply with increasing acidity and is null at pH 7. There is only a slight decrease toward higher pH.

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-9445.
BRENDAi6.3.2.1. 3076.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PANC
OrganismiLotus japonicus (Lotus corniculatus var. japonicus)
Taxonomic identifieri34305 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeLoteaeLotus

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Propeptidei2 – 21Removed; partialPRO_0000023005
Chaini3 – 308306Pantoate--beta-alanine ligasePRO_0000023006Add
BLAST

Expressioni

Tissue specificityi

Expressed at low levels in leaf and root.1 Publication

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliO24035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O24035-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPMVISDKD EMRKWSRSMR SQGKLIALVP TMGFLHEGHL SLVRDAHNHA
60 70 80 90 100
DLVAVSIYVN PGQFSPTEDL SAYPSDFQGD LQKLMSVPGG VDVVFHPHNL
110 120 130 140 150
YDYGGDGGDA VAECGGDGVV SCVDRRSGFG HETWVRAEKL EKPLCGKSRP
160 170 180 190 200
VFFRGVATIV TKLFNIVEPD VAVFGKKDYQ QWKIIQRMVR DLDFSIKVIG
210 220 230 240 250
SEVIREKDGL AMSSRNVYLS PEEREKAVSI NKSLFRAKSA AEDGQIHCEK
260 270 280 290 300
LINLVVQSIT EAGGRIDYAE IVDQNNLEKV EWIKGPVVFC VSAWFGKARL

IDNIEINL
Length:308
Mass (Da):34,240
Last modified:January 23, 2007 - v3
Checksum:i13344F2A8508D2D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10252 mRNA. Translation: CAA71302.1.
UniGeneiLja.12058.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10252 mRNA. Translation: CAA71302.1 .
UniGenei Lja.12058.

3D structure databases

ProteinModelPortali O24035.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci MetaCyc:MONOMER-9445.
BRENDAi 6.3.2.1. 3076.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The final step of pantothenate biosynthesis in higher plants: cloning and characterization of pantothenate synthetase from Lotus japonicus and Oryza sativum (rice)."
    Genschel U., Powell C.A., Abell C., Smith A.G.
    Biochem. J. 341:669-678(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-17, TISSUE SPECIFICITY.
    Strain: cv. Gifu / B-129.
    Tissue: Root nodule.

Entry informationi

Entry nameiPANC_LOTJA
AccessioniPrimary (citable) accession number: O24035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 83 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3