ID   GPX4_SOLLC              Reviewed;         169 AA.
AC   O24031;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 63.
DE   RecName: Full=Probable phospholipid hydroperoxide glutathione peroxidase;
DE            Short=PHGPx;
DE            EC=1.11.1.12;
GN   Name=GPXle-1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae;
OC   Solanum; Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. VFN8;
RX   MEDLINE=98316667; PubMed=9654095;
RX   DOI=10.1046/j.1432-1327.1998.2530445.x;
RA   Depege N., Drevet J., Boyer N.;
RT   "Molecular cloning and characterization of tomato cDNAs encoding
RT   glutathione peroxidase-like proteins.";
RL   Eur. J. Biochem. 253:445-451(1998).
CC   -!- FUNCTION: Protects cells and enzymes from oxidative damage, by
CC       catalyzing the reduction of hydrogen peroxide, lipid peroxides and
CC       organic hydroperoxide, by glutathione (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide =
CC       glutathione disulfide + lipid + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; Y14762; CAA75054.1; -; mRNA.
DR   UniGene; Les.22399; -.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 2665; LeGPx06.
DR   BRENDA; 1.11.1.12; 281054.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0047066; F:phospholipid-hydroperoxide glutathione pero...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Oxidoreductase; Peroxidase.
FT   CHAIN         1    169       Probable phospholipid hydroperoxide
FT                                glutathione peroxidase.
FT                                /FTId=PRO_0000066631.
FT   ACT_SITE     43     43       By similarity.
SQ   SEQUENCE   169 AA;  18847 MW;  3686E83724467650 CRC64;
     MATQTSNPQS VYDFTVKDAK GKDVDLSIYK GKVLIIVNVA SQCGLTNSNY TDMTELYKKY
     KDQGLEILAF PCNQFGGQEP GNIEDIQQMV CTRFKAEYPI FDKVDVNGDN AAPLYRFLKS
     SKGGFFGDGI KWNFSKFLID KEGHVVDRYS PTTSPASMEK DIKKLLGVA
//