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Protein

Probable phospholipid hydroperoxide glutathione peroxidase

Gene

GPXle-1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity

Catalytic activityi

2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase

Protein family/group databases

PeroxiBasei2665 LeGPx06

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipid hydroperoxide glutathione peroxidase (EC:1.11.1.12)
Short name:
PHGPx
Gene namesi
Name:GPXle-1
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
Proteomesi
  • UP000004994 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000666311 – 169Probable phospholipid hydroperoxide glutathione peroxidaseAdd BLAST169

Proteomic databases

PaxDbiO24031
PRIDEiO24031

Expressioni

Gene expression databases

ExpressionAtlasiO24031 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi4081.Solyc08g080940.2.1

Structurei

3D structure databases

ProteinModelPortaliO24031
SMRiO24031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiKOG1651 Eukaryota
COG0386 LUCA
InParanoidiO24031

Family and domain databases

CDDicd00340 GSH_Peroxidase, 1 hit
InterProiView protein in InterPro
IPR000889 Glutathione_peroxidase
IPR029759 GPX_AS
IPR029760 GPX_CS
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR11592 PTHR11592, 1 hit
PfamiView protein in Pfam
PF00255 GSHPx, 1 hit
PIRSFiPIRSF000303 Glutathion_perox, 1 hit
PRINTSiPR01011 GLUTPROXDASE
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00460 GLUTATHIONE_PEROXID_1, 1 hit
PS00763 GLUTATHIONE_PEROXID_2, 1 hit
PS51355 GLUTATHIONE_PEROXID_3, 1 hit

Sequencei

Sequence statusi: Complete.

O24031-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATQTSNPQS VYDFTVKDAK GKDVDLSIYK GKVLIIVNVA SQCGLTNSNY
60 70 80 90 100
TDMTELYKKY KDQGLEILAF PCNQFGGQEP GNIEDIQQMV CTRFKAEYPI
110 120 130 140 150
FDKVDVNGDN AAPLYRFLKS SKGGFFGDGI KWNFSKFLID KEGHVVDRYS
160
PTTSPASMEK DIKKLLGVA
Length:169
Mass (Da):18,847
Last modified:January 1, 1998 - v1
Checksum:i3686E83724467650
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14762 mRNA Translation: CAA75054.1
UniGeneiLes.2489
Les.25765

Similar proteinsi

Entry informationi

Entry nameiGPX4_SOLLC
AccessioniPrimary (citable) accession number: O24031
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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