O24031 (GPX4_SOLLC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid hydroperoxide glutathione peroxidase
Short name=PHGPx
EC=1.11.1.12

Gene names

Name:

GPXle-1

Organism

Solanum lycopersicum (Tomato) (Lycopersicon esculentum)

Taxonomic identifier

4081 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum › Lycopersicon

Protein attributes

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 169	169	Probable phospholipid hydroperoxide glutathione peroxidase		PRO_0000066631
Sites
	Active site	43	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O24031 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 3686E83724467650	FASTA	169	18,847
	10 20 30 40 50 60 MATQTSNPQS VYDFTVKDAK GKDVDLSIYK GKVLIIVNVA SQCGLTNSNY TDMTELYKKY 70 80 90 100 110 120 KDQGLEILAF PCNQFGGQEP GNIEDIQQMV CTRFKAEYPI FDKVDVNGDN AAPLYRFLKS 130 140 150 160 SKGGFFGDGI KWNFSKFLID KEGHVVDRYS PTTSPASMEK DIKKLLGVA

References

[1]	"Molecular cloning and characterization of tomato cDNAs encoding glutathione peroxidase-like proteins." Depege N., Drevet J., Boyer N. Eur. J. Biochem. 253:445-451(1998) [PubMed: 9654095] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. VFN8.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14762 mRNA. Translation: CAA75054.1.
RefSeq	NP_001234567.1. NM_001247638.1.
UniGene	Les.22399.
3D structure databases
ProteinModelPortal	O24031.
SMR	O24031. Positions 5-168.
ModBase	Search...
Protein family/group databases
PeroxiBase	2665. LeGPx06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	544197.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX4_SOLLC

Accession

Primary (citable) accession number: O24031

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	January 1, 1998
Last modified:	December 14, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program