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O24030

- PSA7_SOLLC

UniProt

O24030 - PSA7_SOLLC

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Protein

Proteasome subunit alpha type-7

Gene

PAD1

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha type-7 (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit D
20S proteasome subunit alpha-4
Gene namesi
Name:PAD1
Synonyms:PSR5
OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
Taxonomic identifieri4081 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumLycopersicon
ProteomesiUP000004994: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
  3. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 259259Proteasome subunit alpha type-7PRO_0000124162Add
BLAST

Proteomic databases

PRIDEiO24030.

Interactioni

Subunit structurei

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliO24030.
SMRiO24030. Positions 4-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiO24030.
KOiK02731.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTiSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O24030-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARYDRAITV FSPDGHLFQV EYAMEAVRKG NAAVGVRGTD TVVLGVEKKS
60 70 80 90 100
TPKLQDSRSV RKIVNLDDHI ALACAGLKAD ARVLVNKARI ECQSHRLTVE
110 120 130 140 150
DPVTVEYITR YIAGLQQKYT QSGGVRPFGL STLIIGFDPH TGVPSLYQTD
160 170 180 190 200
PSGTFSAWKA NATGRNSNST REFLEKNYKE TSGQETVKLA IRALLEVVES
210 220 230 240 250
GGKNIEVAVM TKEHGLKQLE EAEIDAIVAE IEAEKAAAEA AKRPHRRNLV

ELKFVLNYP
Length:259
Mass (Da):28,480
Last modified:January 1, 1998 - v1
Checksum:i700B3638C9F0FB52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14339 mRNA. Translation: CAA74725.1.
PIRiT07744.
RefSeqiNP_001234333.1. NM_001247404.1.
UniGeneiLes.1195.

Genome annotation databases

GeneIDi544128.
KEGGisly:544128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14339 mRNA. Translation: CAA74725.1 .
PIRi T07744.
RefSeqi NP_001234333.1. NM_001247404.1.
UniGenei Les.1195.

3D structure databases

ProteinModelPortali O24030.
SMRi O24030. Positions 4-231.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi O24030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 544128.
KEGGi sly:544128.

Phylogenomic databases

InParanoidi O24030.
KOi K02731.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR029055. Ntn_hydrolases_N.
IPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view ]
SMARTi SM00948. Proteasome_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS00388. PROTEASOME_ALPHA_1. 1 hit.
PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of PSR5, a tomato cDNA encoding a 20S subunit from the proteasome repressed by phosphate starvation."
    Ziethe K., Stenzel I., Hertel S.C., Koeck M.
    Plant Gene Register PGR98-065
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Lukullus.

Entry informationi

Entry nameiPSA7_SOLLC
AccessioniPrimary (citable) accession number: O24030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3