Reviewed, UniProtKB/Swiss-Prot O23970 (GPX1_HELAN)

Names and origin

Protein names

Recommended name:
    Glutathione peroxidase 1
    EC=1.11.1.9

Gene names

Name:

GPXHA-1

Organism

Helianthus annuus (Common sunflower)

Taxonomic identifier

4232 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Helianthus

Protein attributes

Sequence length	167 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May constitute a glutathionine peroxidase-like protective system against oxidative stresses.
Catalytic activity	2 glutathione + H2O2 = glutathione disulfide + 2 H2O.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Molecular function	glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 167	167	Glutathione peroxidase 1		PRO_0000066629
Sites
	Active site	41	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O23970-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: CF5AC7ACC76558C9	FASTA	167	18,842
	10 20 30 40 50 60 MATQSKKTLY DFTVKDAKGN DVDLSVYKGK VVLIVNVASK CGLTNNSYDE LNQIYLKYKE 70 80 90 100 110 120 KGFEILAFPC NQFGQQEPGT NEEIVDFVCT KFKSEFPIFD KIDVNGENAA PVYEFLKTGF 130 140 150 160 YGILGGDIQW NFSKFLVDKN GQPVDCYYPT TSPLTVERDI QKLLGLL

References

[1]	Drevet J.R., Gagne G., Tourvieille de Labrouhe D., Nicolas P., Dufaure J.-P., Ledoigt G., Roeckel-Drevet P. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y14429 mRNA. Translation: CAA74775.1.
PIR	T14262.
3D structure databases
HSSP	HSSP built from PDB template 1GP1 based on UniProtKB P00435.
ModBase	Search...
Protein family/group databases
PeroxiBase	2652. HaGPx06-2.
Enzyme and pathway databases
BRENDA	1.11.1.9. 1739.
Family and domain databases
InterPro	IPR000889. Glutathione_peroxidase. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PANTHER	PTHR11592. Glut_peroxidase. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX1_HELAN

Accession

Primary (citable) accession number: O23970

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)