ID   GPX4_HELAN              Reviewed;         180 AA.
AC   O23968;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 52.
DE   RecName: Full=Probable phospholipid hydroperoxide glutathione peroxidase;
DE            Short=PHGPx;
DE            EC=1.11.1.12;
DE   AltName: Full=Glutathione peroxidase 2;
GN   Name=GPXHA-2;
OS   Helianthus annuus (Common sunflower).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Asterales; Asteraceae; Asteroideae;
OC   Heliantheae; Helianthus.
OX   NCBI_TaxID=4232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Drevet J.R., Gagne G., Tourvieille de Labrouhe D., Nicolas P.,
RA   Dufaure J.-P., Ledoigt G., Roeckel-Drevet P.;
RL   Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects cells and enzymes from oxidative damage, by
CC       catalyzing the reduction of hydrogen peroxide, lipid peroxides and
CC       organic hydroperoxide, by glutathione (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide =
CC       glutathione disulfide + lipid + 2 H(2)O.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the glutathione peroxidase family.
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DR   EMBL; Y14707; CAA75009.1; -; mRNA.
DR   PIR; T12633; T12633.
DR   HSSP; P00435; 1GP1.
DR   PeroxiBase; 2650; HaGPx06-1.
DR   BRENDA; 1.11.1.12; 1739.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004602; F:glutathione peroxidase activity; IEA:InterPro.
DR   GO; GO:0047066; F:phospholipid-hydroperoxide glutathione pero...; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   InterPro; IPR000889; Glutathione_peroxidase.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11592; Glut_peroxidase; 1.
DR   Pfam; PF00255; GSHPx; 1.
DR   PIRSF; PIRSF000303; Glutathion_perox; 1.
DR   PRINTS; PR01011; GLUTPROXDASE.
DR   PROSITE; PS00460; GLUTATHIONE_PEROXID_1; 1.
DR   PROSITE; PS00763; GLUTATHIONE_PEROXID_2; 1.
DR   PROSITE; PS51355; GLUTATHIONE_PEROXID_3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Oxidoreductase; Peroxidase.
FT   CHAIN         1    180       Probable phospholipid hydroperoxide
FT                                glutathione peroxidase.
FT                                /FTId=PRO_0000066630.
FT   ACT_SITE     54     54       By similarity.
SQ   SEQUENCE   180 AA;  20174 MW;  E33090EAAD2AADE0 CRC64;
     MATQTVFDFP DDVLQQPPMP ADNAFSDKDV KGQDVELSKY KGKVLLIVNV ASQCGFTNSN
     YPELTTLYQK YKDQGFEILA FPCNQFGGQE PGSNEEIQVF ACTRFKAEYP VFSKVNVNGK
     EADPLYKFLK SSKGGFLGDS IKWNFTKFLV DREGKVVDRY APTTSPLSIE KDIKKLLNVA
//