O23968 (GPX4_HELAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid hydroperoxide glutathione peroxidase
Short name=PHGPx
EC=1.11.1.12

Alternative name(s):
Glutathione peroxidase 2

Gene names

Name:

GPXHA-2

Organism

Helianthus annuus (Common sunflower)

Taxonomic identifier

4232 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Helianthus

Protein attributes

Sequence length	180 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione By similarity.
Catalytic activity	2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H2O.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the glutathione peroxidase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological_process	response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutathione peroxidase activity Inferred from electronic annotation. Source: InterPro phospholipid-hydroperoxide glutathione peroxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 180	180	Probable phospholipid hydroperoxide glutathione peroxidase		PRO_0000066630
Sites
	Active site	54	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	O23968 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: E33090EAAD2AADE0	FASTA	180	20,174
	10 20 30 40 50 60 MATQTVFDFP DDVLQQPPMP ADNAFSDKDV KGQDVELSKY KGKVLLIVNV ASQCGFTNSN 70 80 90 100 110 120 YPELTTLYQK YKDQGFEILA FPCNQFGGQE PGSNEEIQVF ACTRFKAEYP VFSKVNVNGK 130 140 150 160 170 180 EADPLYKFLK SSKGGFLGDS IKWNFTKFLV DREGKVVDRY APTTSPLSIE KDIKKLLNVA

References

[1]	Drevet J.R., Gagne G., Tourvieille de Labrouhe D., Nicolas P., Dufaure J.-P., Ledoigt G., Roeckel-Drevet P. Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y14707 mRNA. Translation: CAA75009.1.
PIR	T12633.
3D structure databases
ProteinModelPortal	O23968.
SMR	O23968. Positions 25-180.
ModBase	Search...
Protein family/group databases
PeroxiBase	2650. HaGPx06-1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.30.10. 1 hit.
InterPro	IPR000889. Glutathione_peroxidase. IPR012336. Thioredoxin-like_fold. [Graphical view]
PANTHER	PTHR11592. PTHR11592. 1 hit.
Pfam	PF00255. GSHPx. 1 hit. [Graphical view]
PIRSF	PIRSF000303. Glutathion_perox. 1 hit.
PRINTS	PR01011. GLUTPROXDASE.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00460. GLUTATHIONE_PEROXID_1. 1 hit. PS00763. GLUTATHIONE_PEROXID_2. 1 hit. PS51355. GLUTATHIONE_PEROXID_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPX4_HELAN

Accession

Primary (citable) accession number: O23968

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	March 6, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program