ID   HPPD_DAUCA              Reviewed;         442 AA.
AC   O23920;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   16-JUN-2009, entry version 59.
DE   RecName: Full=4-hydroxyphenylpyruvate dioxygenase;
DE            EC=1.13.11.27;
DE   AltName: Full=4-hydroxyphenylpyruvic acid oxidase;
DE            Short=HPPDase;
DE            Short=4HPPD;
DE            Short=HPD;
OS   Daucus carota (Carrot).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae;
OC   Daucinae; Daucus.
OX   NCBI_TaxID=4039;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=97373528; PubMed=9271098;
RA   Garcia I., Rodgers M., Lenne C., Rolland A., Sailland A., Matringe M.;
RT   "Subcellular localization and purification of a p-
RT   hydroxyphenylpyruvate dioxygenase from cultured carrot cells and
RT   characterization of the corresponding cDNA.";
RL   Biochem. J. 325:761-769(1997).
CC   -!- CATALYTIC ACTIVITY: 4-hydroxyphenylpyruvate + O(2) = homogentisate
CC       + CO(2).
CC   -!- COFACTOR: Binds 1 iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 3/6.
CC   -!- PATHWAY: Cofactor biosynthesis; prenylquinone biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the 4HPPD family.
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DR   EMBL; U87257; AAC49815.1; -; mRNA.
DR   PIR; T14353; T14353.
DR   SMR; O23920; 32-430.
DR   BRENDA; 1.13.11.27; 1081.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:EC.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   PANTHER; PTHR11959; HPP_dOase; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   PIRSF; PIRSF009283; HPP_dOase; 1.
DR   TIGRFAMs; TIGR01263; 4HPPD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    442       4-hydroxyphenylpyruvate dioxygenase.
FT                                /FTId=PRO_0000088398.
FT   METAL       219    219       Iron (By similarity).
FT   METAL       301    301       Iron (By similarity).
FT   METAL       387    387       Iron (By similarity).
SQ   SEQUENCE   442 AA;  48148 MW;  A484AFFA267F7BF7 CRC64;
     MGKKQSEAEI LSSNSSNTSP ATFKLVGFNN FVRANPKSDH FAVKRFHHIE FWCGDATNTS
     RRFSWGLGMP LVAKSDLSTG NSVHASYLVR SANLSFVFTA PYSPSTTTSS GSAAIPSFSA
     SGFHSFAAKH GLAVRAIALE VADVAAAFEA SVARGARPAS APVELDDQAW LAEVELYGDV
     VLRFVSFGRE EGLFLPGFEA VEGTASFPDL DYGIRRLDHA VGNVTELGPV VEYIKGFTGF
     HEFAEFTAED VGTLESGLNS VVLANNEEMV LLPLNEPVYG TKRKSQIQTY LEHNEGAGVQ
     HLALVSEDIF RTLREMRKRS CLGGFEFMPS PPPTYYKNLK NRVGDVLSDE QIKECEDLGI
     LVDRDDQGTL LQIFTKPVGD RPTLFIEIIQ RVGCMLKDDA GQMYQKGGCG GFGKGNFSEL
     FKSIEEYEKT LEAKQITGSA AA
//