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O23731 (CHS8_BROFI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chalcone synthase 8

EC=2.3.1.74
Alternative name(s):
Naringenin-chalcone synthase 8
Gene names
Name:CHS8
OrganismBromheadia finlaysoniana (Orchid)
Taxonomic identifier41205 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesOrchidaceaeEpidendroideaeCymbidieaeBromheadiinaeBromheadia

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activity

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.

Pathway

Secondary metabolite biosynthesis; flavonoid biosynthesis.

Sequence similarities

Belongs to the chalcone/stilbene synthases family.

Ontologies

Keywords
   Biological processFlavonoid biosynthesis
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological_processflavonoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionnaringenin-chalcone synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Chalcone synthase 8
PRO_0000215958

Sites

Active site1651 By similarity

Sequences

Sequence LengthMass (Da)Tools
O23731 [UniParc].

Last modified January 1, 1998. Version 1.
Checksum: FBA6117CA54BB323

FASTA39442,914
        10         20         30         40         50         60 
MAPAMEEIRQ AQRAEGPAAV LAIGTSTPPN ALYQADYPDY YFRITKSEHL TELKEKFKRM 

        70         80         90        100        110        120 
CDKSMIKKRY MYLTEEILKE NPNICAFMAP SLDARQDIVV TEVPKLAKEA AARAIKEWGH 

       130        140        150        160        170        180 
PKSRITHLIF CTTSGIDMPG ADYQLTRLLG LRPSVNRFML YQQGCFAGGT VLRLAKDLAE 

       190        200        210        220        230        240 
NNAGARVLVV CSEITAVTFR GPSESHLDSL VGQALFGDGA AAIIVGSDPD SATERPLFQL 

       250        260        270        280        290        300 
VSASQTILPE SEGAIDGHLR EIGLTFHLLK DVPGLISKNI QKCLLDAFKP LGVHDWNSIF 

       310        320        330        340        350        360 
WIAHPGGPAI LDQVEIKLGL KAEKLAASRN VLAEYGNMSS ACVLFILDEM RRRSAEAGQA 

       370        380        390 
TTGEGLEWGV LFGFGPGLTV ETIVLRSVPI AGAE 

« Hide

References

[1]"Molecular cloning and sequence analysis of chalcone synthase cDNAs of Bromheadia finlaysoniana."
Liew C.F., Lim S.H., Loh C.S., Goh C.J.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Flower.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007099 mRNA. Translation: AAB62876.1.

3D structure databases

ProteinModelPortalO23731.
SMRO23731. Positions 4-390.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00154.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFPIRSF000451. PKS_III. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCHS8_BROFI
AccessionPrimary (citable) accession number: O23731
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 16, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways