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O23731

- CHS8_BROFI

UniProt

O23731 - CHS8_BROFI

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Protein

Chalcone synthase 8

Gene

CHS8

Organism
Bromheadia finlaysoniana (Orchid)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 8 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 8
Gene namesi
Name:CHS8
OrganismiBromheadia finlaysoniana (Orchid)
Taxonomic identifieri41205 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesOrchidaceaeEpidendroideaeCymbidieaeBromheadiinaeBromheadia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Chalcone synthase 8PRO_0000215958Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliO23731.
SMRiO23731. Positions 4-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O23731 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPAMEEIRQ AQRAEGPAAV LAIGTSTPPN ALYQADYPDY YFRITKSEHL
60 70 80 90 100
TELKEKFKRM CDKSMIKKRY MYLTEEILKE NPNICAFMAP SLDARQDIVV
110 120 130 140 150
TEVPKLAKEA AARAIKEWGH PKSRITHLIF CTTSGIDMPG ADYQLTRLLG
160 170 180 190 200
LRPSVNRFML YQQGCFAGGT VLRLAKDLAE NNAGARVLVV CSEITAVTFR
210 220 230 240 250
GPSESHLDSL VGQALFGDGA AAIIVGSDPD SATERPLFQL VSASQTILPE
260 270 280 290 300
SEGAIDGHLR EIGLTFHLLK DVPGLISKNI QKCLLDAFKP LGVHDWNSIF
310 320 330 340 350
WIAHPGGPAI LDQVEIKLGL KAEKLAASRN VLAEYGNMSS ACVLFILDEM
360 370 380 390
RRRSAEAGQA TTGEGLEWGV LFGFGPGLTV ETIVLRSVPI AGAE
Length:394
Mass (Da):42,914
Last modified:January 1, 1998 - v1
Checksum:iFBA6117CA54BB323
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007099 mRNA. Translation: AAB62876.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007099 mRNA. Translation: AAB62876.1 .

3D structure databases

ProteinModelPortali O23731.
SMRi O23731. Positions 4-390.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00154 .

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000451. PKS_III. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
PROSITEi PS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and sequence analysis of chalcone synthase cDNAs of Bromheadia finlaysoniana."
    Liew C.F., Lim S.H., Loh C.S., Goh C.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Flower.

Entry informationi

Entry nameiCHS8_BROFI
AccessioniPrimary (citable) accession number: O23731
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3