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Protein

Chalcone synthase 4

Gene

CHS4

Organism
Bromheadia finlaysoniana (Orchid)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651PROSITE-ProRule annotation

GO - Molecular functioni

  1. naringenin-chalcone synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. flavonoid biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 4 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 4
Gene namesi
Name:CHS4
OrganismiBromheadia finlaysoniana (Orchid)
Taxonomic identifieri41205 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesOrchidaceaeEpidendroideaeCymbidieaeBromheadiinaeBromheadia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Chalcone synthase 4PRO_0000215957Add
BLAST

Proteomic databases

PRIDEiO23730.

Structurei

3D structure databases

ProteinModelPortaliO23730.
SMRiO23730. Positions 4-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O23730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAMEEIRQ AQRAEGPAAV LAIGTSTPPN ALYQADYPDY YFRITKSEHL
60 70 80 90 100
TELKEKFKRM CDKSMIKKRY MYLTEEILKE NPNICAFMAP SLDARQDIVV
110 120 130 140 150
TEVPKLAKEA AVRAIKEWGH PKSRITHLIF CTTSGIDMPG ADYQLTRLLG
160 170 180 190 200
LRPSVNRFML YQQGCFAGGT VLRLAKDLAE NNAGARVLVV CSEITAVTFR
210 220 230 240 250
GPSESHLDSL VGQALFGDGA AAIIVGSDPD SATERPLFQL VSASQTILPE
260 270 280 290 300
SEGAIDGHLR EIGLTFHLLK DVPGLISKNI QKCLLDAFKP LGVHDWNSIF
310 320 330 340 350
WIAHPGGPAI LDQVEIKLGL KAEKLAASRS VLAEYGNMSS ACVLFILDEM
360 370 380 390
RRRSAEAGQA TTGEGLEWGV LFGFGPGLTV ETIVLRSVPI AGAE
Length:394
Mass (Da):42,915
Last modified:January 1, 1998 - v1
Checksum:i3E6CE4BEA980BBB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007098 mRNA. Translation: AAB62875.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007098 mRNA. Translation: AAB62875.1.

3D structure databases

ProteinModelPortaliO23730.
SMRiO23730. Positions 4-390.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiO23730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and sequence analysis of chalcone synthase cDNAs of Bromheadia finlaysoniana."
    Liew C.F., Lim S.H., Loh C.S., Goh C.J.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Flower.

Entry informationi

Entry nameiCHS4_BROFI
AccessioniPrimary (citable) accession number: O23730
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: October 1, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.