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Protein

Chalcone synthase 3

Gene

CHS3

Organism
Bromheadia finlaysoniana (Orchid)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi: flavonoid biosynthesis

This protein is involved in the pathway flavonoid biosynthesis, which is part of Secondary metabolite biosynthesis.
View all proteins of this organism that are known to be involved in the pathway flavonoid biosynthesis and in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei165PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFlavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 3 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 3
Gene namesi
Name:CHS3
OrganismiBromheadia finlaysoniana (Orchid)
Taxonomic identifieri41205 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaAsparagalesOrchidaceaeEpidendroideaeVandeaeAdrorhizinaeBromheadia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002159561 – 394Chalcone synthase 3Add BLAST394

Proteomic databases

PRIDEiO23729.

Structurei

3D structure databases

ProteinModelPortaliO23729.
SMRiO23729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
PANTHERiPTHR11877. PTHR11877. 1 hit.
PfamiView protein in Pfam
PF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiView protein in PROSITE
PS00441. CHALCONE_SYNTH. 1 hit.

Sequencei

Sequence statusi: Complete.

O23729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPAMEEIRQ AQRAEGPAAV LAIGTSTPPN ALYQADYPDY YFRITKSEHL
60 70 80 90 100
TELKEKFKRM CDKSMIKKRY MYLTEEILKE NPNICAFMAP SLDARQDIVV
110 120 130 140 150
TEVPKLAKEA AVRAIKEWGH PKSRITHLIF CTTSGIDMPG ADYQLTRLLG
160 170 180 190 200
LRPSVNRFML YQQGCFAGGT VLRLAKDLAE NNAGARVLVV CSEITAVTFR
210 220 230 240 250
GPSESHLDSL VGQALFGDGA AAIIVGSDPD SATERPLFQL VSASQTILPE
260 270 280 290 300
SEGAIDGHLR EIGLTFHLLK DVPGLISKNI QKCLLDAFKP LGVHDWNSIF
310 320 330 340 350
WIAHPGGPAI LDQVEIKLGL KAEKLAASRN VLAEYGNMSS ACVLFILDEM
360 370 380 390
RRRSAEAGQA TTGEGLEWGV LFGFGPGLTV ETIVLRSVPI AGAE
Length:394
Mass (Da):42,942
Last modified:January 1, 1998 - v1
Checksum:i2F8D14AF4870BBB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007097 mRNA. Translation: AAB62874.1.

Similar proteinsi

Entry informationi

Entry nameiCHS3_BROFI
AccessioniPrimary (citable) accession number: O23729
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: January 1, 1998
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families