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O23657

- RABC1_ARATH

UniProt

O23657 - RABC1_ARATH

Protein

Ras-related protein RABC1

Gene

RABC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Intracellular vesicle trafficking and protein transport.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi20 – 278GTPBy similarity
    Nucleotide bindingi67 – 715GTPBy similarity
    Nucleotide bindingi127 – 1304GTPBy similarity
    Nucleotide bindingi157 – 1582GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein RABC1
    Short name:
    AtRABC1
    Alternative name(s):
    Ras-related protein Rab18
    Short name:
    AtRab18
    Gene namesi
    Name:RABC1
    Synonyms:RAB18, RAB18-1
    Ordered Locus Names:At1g43890
    ORF Names:F28H19.15, F9C16.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G43890.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. plasma membrane Source: TAIR

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 212211Ras-related protein RABC1PRO_0000407357Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylglycine1 Publication
    Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity
    Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiO23657.
    PRIDEiO23657.

    Expressioni

    Gene expression databases

    GenevestigatoriO23657.

    Interactioni

    Protein-protein interaction databases

    IntActiO23657. 1 interaction.
    STRINGi3702.AT1G43890.2-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO23657.
    SMRiO23657. Positions 14-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi41 – 499Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    InParanoidiO23657.
    KOiK07910.
    OMAiKYLTIGE.
    PhylomeDBiO23657.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    O23657-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSSSGQPEF DYLFKVLLIG DSGVGKSSLL LSFTSNTFDD LSPTIGVDFK    50
    VKYLTIGEKK LKLAIWDTAG QERFRTLTSS YYRGAQGIIM VYDVTRRDTF 100
    TNLSDIWAKE IDLYSTNQDC IKMLVGNKVD KESERAVSKK EGIDFAREYG 150
    CLFLECSAKT RVNVEQCFEE LVLKILETPS LTAEGSSGGK KNIFKQNPAQ 200
    TTSTSSSYCC SS 212
    Length:212
    Mass (Da):23,531
    Last modified:January 1, 1998 - v1
    Checksum:i042AFFE8C133612C
    GO

    Sequence cautioni

    The sequence AAF79660.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75603 mRNA. Translation: AAB61997.1.
    AC006423 Genomic DNA. Translation: AAF63103.1.
    AC022314 Genomic DNA. Translation: AAF79660.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32003.1.
    CP002684 Genomic DNA. Translation: AEE32004.1.
    CP002684 Genomic DNA. Translation: AEE32005.1.
    AF370263 mRNA. Translation: AAK44078.1.
    AY063080 mRNA. Translation: AAL34254.1.
    AK227664 mRNA. Translation: BAE99651.1.
    AY086878 mRNA. Translation: AAM63924.1.
    PIRiA96503.
    RefSeqiNP_001077675.1. NM_001084206.1.
    NP_001117435.1. NM_001123963.1.
    NP_175056.1. NM_103516.3.
    UniGeneiAt.24663.

    Genome annotation databases

    EnsemblPlantsiAT1G43890.1; AT1G43890.1; AT1G43890.
    AT1G43890.2; AT1G43890.2; AT1G43890.
    AT1G43890.3; AT1G43890.3; AT1G43890.
    GeneIDi840987.
    KEGGiath:AT1G43890.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U75603 mRNA. Translation: AAB61997.1 .
    AC006423 Genomic DNA. Translation: AAF63103.1 .
    AC022314 Genomic DNA. Translation: AAF79660.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE32003.1 .
    CP002684 Genomic DNA. Translation: AEE32004.1 .
    CP002684 Genomic DNA. Translation: AEE32005.1 .
    AF370263 mRNA. Translation: AAK44078.1 .
    AY063080 mRNA. Translation: AAL34254.1 .
    AK227664 mRNA. Translation: BAE99651.1 .
    AY086878 mRNA. Translation: AAM63924.1 .
    PIRi A96503.
    RefSeqi NP_001077675.1. NM_001084206.1.
    NP_001117435.1. NM_001123963.1.
    NP_175056.1. NM_103516.3.
    UniGenei At.24663.

    3D structure databases

    ProteinModelPortali O23657.
    SMRi O23657. Positions 14-181.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi O23657. 1 interaction.
    STRINGi 3702.AT1G43890.2-P.

    Proteomic databases

    PaxDbi O23657.
    PRIDEi O23657.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G43890.1 ; AT1G43890.1 ; AT1G43890 .
    AT1G43890.2 ; AT1G43890.2 ; AT1G43890 .
    AT1G43890.3 ; AT1G43890.3 ; AT1G43890 .
    GeneIDi 840987.
    KEGGi ath:AT1G43890.

    Organism-specific databases

    TAIRi AT1G43890.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    InParanoidi O23657.
    KOi K07910.
    OMAi KYLTIGE.
    PhylomeDBi O23657.

    Miscellaneous databases

    PROi O23657.

    Gene expression databases

    Genevestigatori O23657.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A member of the Rab18-family from Arabidopsis thaliana."
      Bischoff F., Palme K.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    6. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Analysis of the small GTPase gene superfamily of Arabidopsis."
      Vernoud V., Horton A.C., Yang Z., Nielsen E.
      Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRABC1_ARATH
    AccessioniPrimary (citable) accession number: O23657
    Secondary accession number(s): Q9LP15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3