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Protein

Ras-related protein RABC1

Gene

RABC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Intracellular vesicle trafficking and protein transport.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi20 – 278GTPBy similarity
Nucleotide bindingi67 – 715GTPBy similarity
Nucleotide bindingi127 – 1304GTPBy similarity
Nucleotide bindingi157 – 1582GTPBy similarity

GO - Molecular functioni

  1. GDP binding Source: GO_Central
  2. GTPase activity Source: GO_Central
  3. GTP binding Source: GO_Central

GO - Biological processi

  1. GTP catabolic process Source: GO_Central
  2. intracellular protein transport Source: GO_Central
  3. Rab protein signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABC1
Short name:
AtRABC1
Alternative name(s):
Ras-related protein Rab18
Short name:
AtRab18
Gene namesi
Name:RABC1
Synonyms:RAB18, RAB18-1
Ordered Locus Names:At1g43890
ORF Names:F28H19.15, F9C16.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G43890.

Subcellular locationi

Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

GO - Cellular componenti

  1. Golgi apparatus Source: GO_Central
  2. plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 212211Ras-related protein RABC1PRO_0000407357Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Lipidationi209 – 2091S-geranylgeranyl cysteineBy similarity
Lipidationi210 – 2101S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Prenylation

Proteomic databases

PaxDbiO23657.
PRIDEiO23657.

Expressioni

Gene expression databases

GenevestigatoriO23657.

Interactioni

Protein-protein interaction databases

IntActiO23657. 1 interaction.
STRINGi3702.AT1G43890.2-P.

Structurei

3D structure databases

ProteinModelPortaliO23657.
SMRiO23657. Positions 14-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi41 – 499Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
InParanoidiO23657.
KOiK07910.
OMAiVICVYDV.
PhylomeDBiO23657.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSSSGQPEF DYLFKVLLIG DSGVGKSSLL LSFTSNTFDD LSPTIGVDFK
60 70 80 90 100
VKYLTIGEKK LKLAIWDTAG QERFRTLTSS YYRGAQGIIM VYDVTRRDTF
110 120 130 140 150
TNLSDIWAKE IDLYSTNQDC IKMLVGNKVD KESERAVSKK EGIDFAREYG
160 170 180 190 200
CLFLECSAKT RVNVEQCFEE LVLKILETPS LTAEGSSGGK KNIFKQNPAQ
210
TTSTSSSYCC SS
Length:212
Mass (Da):23,531
Last modified:January 1, 1998 - v1
Checksum:i042AFFE8C133612C
GO

Sequence cautioni

The sequence AAF79660.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75603 mRNA. Translation: AAB61997.1.
AC006423 Genomic DNA. Translation: AAF63103.1.
AC022314 Genomic DNA. Translation: AAF79660.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32003.1.
CP002684 Genomic DNA. Translation: AEE32004.1.
CP002684 Genomic DNA. Translation: AEE32005.1.
AF370263 mRNA. Translation: AAK44078.1.
AY063080 mRNA. Translation: AAL34254.1.
AK227664 mRNA. Translation: BAE99651.1.
AY086878 mRNA. Translation: AAM63924.1.
PIRiA96503.
RefSeqiNP_001077675.1. NM_001084206.1.
NP_001117435.1. NM_001123963.1.
NP_175056.1. NM_103516.3.
UniGeneiAt.24663.

Genome annotation databases

EnsemblPlantsiAT1G43890.1; AT1G43890.1; AT1G43890.
AT1G43890.2; AT1G43890.2; AT1G43890.
AT1G43890.3; AT1G43890.3; AT1G43890.
GeneIDi840987.
KEGGiath:AT1G43890.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U75603 mRNA. Translation: AAB61997.1.
AC006423 Genomic DNA. Translation: AAF63103.1.
AC022314 Genomic DNA. Translation: AAF79660.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE32003.1.
CP002684 Genomic DNA. Translation: AEE32004.1.
CP002684 Genomic DNA. Translation: AEE32005.1.
AF370263 mRNA. Translation: AAK44078.1.
AY063080 mRNA. Translation: AAL34254.1.
AK227664 mRNA. Translation: BAE99651.1.
AY086878 mRNA. Translation: AAM63924.1.
PIRiA96503.
RefSeqiNP_001077675.1. NM_001084206.1.
NP_001117435.1. NM_001123963.1.
NP_175056.1. NM_103516.3.
UniGeneiAt.24663.

3D structure databases

ProteinModelPortaliO23657.
SMRiO23657. Positions 14-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO23657. 1 interaction.
STRINGi3702.AT1G43890.2-P.

Proteomic databases

PaxDbiO23657.
PRIDEiO23657.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G43890.1; AT1G43890.1; AT1G43890.
AT1G43890.2; AT1G43890.2; AT1G43890.
AT1G43890.3; AT1G43890.3; AT1G43890.
GeneIDi840987.
KEGGiath:AT1G43890.

Organism-specific databases

TAIRiAT1G43890.

Phylogenomic databases

eggNOGiCOG1100.
HOGENOMiHOG000233968.
InParanoidiO23657.
KOiK07910.
OMAiVICVYDV.
PhylomeDBiO23657.

Miscellaneous databases

PROiO23657.

Gene expression databases

GenevestigatoriO23657.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A member of the Rab18-family from Arabidopsis thaliana."
    Bischoff F., Palme K.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "Analysis of the small GTPase gene superfamily of Arabidopsis."
    Vernoud V., Horton A.C., Yang Z., Nielsen E.
    Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRABC1_ARATH
AccessioniPrimary (citable) accession number: O23657
Secondary accession number(s): Q9LP15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: January 1, 1998
Last modified: February 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.