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Protein

Histone H2A variant 1

Gene

H2AV

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Variant histone H2A which may replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • defense response to bacterium Source: TAIR
  • detection of temperature stimulus Source: TAIR
  • flower development Source: TAIR

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A variant 1
Alternative name(s):
H2A.F/Z 1
H2AvAt
HTA11
Gene namesi
Name:H2AV
Ordered Locus Names:At3g54560
ORF Names:T14E10.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:2096951. AT3G54560.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553121 – 136Histone H2A variant 1Add BLAST136

Proteomic databases

PaxDbiO23628.
PRIDEiO23628.

Expressioni

Inductioni

Restricted to actively growing cells. Peak of accumulation in the G1/S boundary and in the S phase.1 Publication

Gene expression databases

ExpressionAtlasiO23628. baseline and differential.
GenevisibleiO23628. AT.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
SWC2F4IP063EBI-1537433,EBI-1537394

Protein-protein interaction databases

BioGridi9937. 1 interactor.
IntActiO23628. 2 interactors.
STRINGi3702.AT3G54560.1.

Structurei

3D structure databases

ProteinModelPortaliO23628.
SMRiO23628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
HOGENOMiHOG000234652.
InParanoidiO23628.
KOiK11251.
OMAiXFPVGRI.
OrthoDBiEOG09360UZS.
PhylomeDBiO23628.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

O23628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKGGKGLV AAKTMAANKD KDKDKKKPIS RSARAGIQFP VGRIHRQLKT
60 70 80 90 100
RVSAHGRVGA TAAVYTASIL EYLTAEVLEL AGNASKDLKV KRITPRHLQL
110 120 130
AIRGDEELDT LIKGTIAGGG VIPHIHKSLI NKTTKE
Length:136
Mass (Da):14,541
Last modified:January 1, 1998 - v1
Checksum:i6BD03677F6BBEA1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12575 mRNA. Translation: CAA73155.1.
AL138656 Genomic DNA. Translation: CAB77576.1.
CP002686 Genomic DNA. Translation: AEE79250.1.
BT005205 mRNA. Translation: AAO63269.1.
AY087232 mRNA. Translation: AAM64788.1.
PIRiT47615.
RefSeqiNP_001325682.1. NM_001339683.1.
NP_191019.1. NM_115313.5.
UniGeneiAt.78.

Genome annotation databases

EnsemblPlantsiAT3G54560.1; AT3G54560.1; AT3G54560.
AT3G54560.2; AT3G54560.2; AT3G54560.
GeneIDi824621.
GrameneiAT3G54560.1; AT3G54560.1; AT3G54560.
AT3G54560.2; AT3G54560.2; AT3G54560.
KEGGiath:AT3G54560.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12575 mRNA. Translation: CAA73155.1.
AL138656 Genomic DNA. Translation: CAB77576.1.
CP002686 Genomic DNA. Translation: AEE79250.1.
BT005205 mRNA. Translation: AAO63269.1.
AY087232 mRNA. Translation: AAM64788.1.
PIRiT47615.
RefSeqiNP_001325682.1. NM_001339683.1.
NP_191019.1. NM_115313.5.
UniGeneiAt.78.

3D structure databases

ProteinModelPortaliO23628.
SMRiO23628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9937. 1 interactor.
IntActiO23628. 2 interactors.
STRINGi3702.AT3G54560.1.

Proteomic databases

PaxDbiO23628.
PRIDEiO23628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G54560.1; AT3G54560.1; AT3G54560.
AT3G54560.2; AT3G54560.2; AT3G54560.
GeneIDi824621.
GrameneiAT3G54560.1; AT3G54560.1; AT3G54560.
AT3G54560.2; AT3G54560.2; AT3G54560.
KEGGiath:AT3G54560.

Organism-specific databases

AraportiAT3G54560.
TAIRilocus:2096951. AT3G54560.

Phylogenomic databases

eggNOGiKOG1757. Eukaryota.
COG5262. LUCA.
HOGENOMiHOG000234652.
InParanoidiO23628.
KOiK11251.
OMAiXFPVGRI.
OrthoDBiEOG09360UZS.
PhylomeDBiO23628.

Miscellaneous databases

PROiO23628.

Gene expression databases

ExpressionAtlasiO23628. baseline and differential.
GenevisibleiO23628. AT.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR002119. Histone_H2A.
IPR007125. Histone_H2A/H2B/H3.
IPR032454. Histone_H2A_C.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PF16211. Histone_H2A_C. 1 hit.
PRINTSiPR00620. HISTONEH2A.
SMARTiView protein in SMART
SM00414. H2A. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2AV1_ARATH
AccessioniPrimary (citable) accession number: O23628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 1, 1998
Last modified: February 15, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.