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Protein

Histone H2A variant 1

Gene

H2AV

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Variant histone H2A which may replace conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • chromatin silencing Source: GO_Central
  • defense response to bacterium Source: TAIR
  • detection of temperature stimulus Source: TAIR
  • flower development Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to osmotic stress Source: TAIR

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-ATH-212300 PRC2 methylates histones and DNA
R-ATH-2299718 Condensation of Prophase Chromosomes
R-ATH-2559580 Oxidative Stress Induced Senescence
R-ATH-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-ATH-5578749 Transcriptional regulation by small RNAs
R-ATH-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-ATH-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2A variant 1
Alternative name(s):
H2A.F/Z 1
H2AvAt
HTA11
Gene namesi
Name:H2AV
Ordered Locus Names:At3g54560
ORF Names:T14E10.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G54560
TAIRilocus:2096951 AT3G54560

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000553121 – 136Histone H2A variant 1Add BLAST136

Proteomic databases

PaxDbiO23628
PRIDEiO23628

Expressioni

Inductioni

Restricted to actively growing cells. Peak of accumulation in the G1/S boundary and in the S phase.1 Publication

Gene expression databases

ExpressionAtlasiO23628 baseline and differential
GenevisibleiO23628 AT

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
SWC2F4IP063EBI-1537433,EBI-1537394

GO - Molecular functioni

Protein-protein interaction databases

BioGridi9937, 1 interactor
IntActiO23628, 2 interactors
STRINGi3702.AT3G54560.1

Structurei

3D structure databases

ProteinModelPortaliO23628
SMRiO23628
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2A family.Curated

Phylogenomic databases

eggNOGiKOG1757 Eukaryota
COG5262 LUCA
HOGENOMiHOG000234652
InParanoidiO23628
KOiK11251
OMAiKQRTQHN
OrthoDBiEOG09360UZS
PhylomeDBiO23628

Family and domain databases

CDDicd00074 H2A, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR002119 Histone_H2A
IPR007125 Histone_H2A/H2B/H3
IPR032454 Histone_H2A_C
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PF16211 Histone_H2A_C, 1 hit
PRINTSiPR00620 HISTONEH2A
SMARTiView protein in SMART
SM00414 H2A, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

O23628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKGGKGLV AAKTMAANKD KDKDKKKPIS RSARAGIQFP VGRIHRQLKT
60 70 80 90 100
RVSAHGRVGA TAAVYTASIL EYLTAEVLEL AGNASKDLKV KRITPRHLQL
110 120 130
AIRGDEELDT LIKGTIAGGG VIPHIHKSLI NKTTKE
Length:136
Mass (Da):14,541
Last modified:January 1, 1998 - v1
Checksum:i6BD03677F6BBEA1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y12575 mRNA Translation: CAA73155.1
AL138656 Genomic DNA Translation: CAB77576.1
CP002686 Genomic DNA Translation: AEE79250.1
CP002686 Genomic DNA Translation: ANM63607.1
BT005205 mRNA Translation: AAO63269.1
AY087232 mRNA Translation: AAM64788.1
PIRiT47615
RefSeqiNP_001325682.1, NM_001339683.1
NP_191019.1, NM_115313.5
UniGeneiAt.78

Genome annotation databases

EnsemblPlantsiAT3G54560.1; AT3G54560.1; AT3G54560
AT3G54560.2; AT3G54560.2; AT3G54560
GeneIDi824621
GrameneiAT3G54560.1; AT3G54560.1; AT3G54560
AT3G54560.2; AT3G54560.2; AT3G54560
KEGGiath:AT3G54560

Similar proteinsi

Entry informationi

Entry nameiH2AV1_ARATH
AccessioniPrimary (citable) accession number: O23628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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