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Protein

Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 5

Gene

TPS5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

2-deoxyglucose, but not phenformin, enhances the phosphorylation of TPS5.

Catalytic activityi

UDP-alpha-D-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Protein family/group databases

CAZyiGT20 Glycosyltransferase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 5 (EC:2.4.1.15)
Alternative name(s):
Trehalose-6-phosphate synthase 5
Short name:
AtTPS5
Gene namesi
Name:TPS5
Ordered Locus Names:At4g17770
ORF Names:dl4920W, FCAALL.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT4G17770
TAIRilocus:2129425 AT4G17770

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi5S → A: Abolishes binding to GRF/14-3-3. 1 Publication1
Mutagenesisi32T → A: Abolishes binding to GRF/14-3-3. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003248261 – 862Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 5Add BLAST862

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5Phosphoserine1 Publication1
Modified residuei32Phosphothreonine1 Publication1

Post-translational modificationi

Both Ser-5 and Thr-32 must be phosphorylated for binding to GRF/14-3-3.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO23617
PRIDEiO23617

PTM databases

iPTMnetiO23617

Expressioni

Tissue specificityi

Low expression in leaves, stems, flower buds, flowers and siliques.1 Publication

Inductioni

90-fold induction by sucrose after 24 hours and by heat stress.2 Publications

Gene expression databases

ExpressionAtlasiO23617 baseline and differential
GenevisibleiO23617 AT

Interactioni

Subunit structurei

Binds to the phosphopeptide-binding site of GRF/14-3-3 and to MBF1c.

Protein-protein interaction databases

BioGridi12791, 2 interactors
STRINGi3702.AT4G17770.1

Structurei

3D structure databases

ProteinModelPortaliO23617
SMRiO23617
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni60 – 546GlycosyltransferaseAdd BLAST487

Sequence similaritiesi

In the N-terminal section; belongs to the glycosyltransferase 20 family.Curated
In the C-terminal section; belongs to the trehalose phosphatase family.Curated

Phylogenomic databases

eggNOGiKOG1050 Eukaryota
COG0380 LUCA
COG1877 LUCA
HOGENOMiHOG000191476
InParanoidiO23617
KOiK16055
OMAiLWQYRDA
OrthoDBiEOG093601RY
PhylomeDBiO23617

Family and domain databases

CDDicd03788 GT1_TPS, 1 hit
Gene3Di3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR001830 Glyco_trans_20
IPR036412 HAD-like_sf
IPR006379 HAD-SF_hydro_IIB
IPR023214 HAD_sf
IPR003337 Trehalose_PPase
PfamiView protein in Pfam
PF00982 Glyco_transf_20, 1 hit
PF02358 Trehalose_PPase, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01484 HAD-SF-IIB, 1 hit
TIGR00685 T6PP, 1 hit

Sequencei

Sequence statusi: Complete.

O23617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSRSYSNLL DLASGNFHSF SREKKRFPRV ATVTGVLSEL DDDNNSNSVC
60 70 80 90 100
SDAPSSVTQD RIIIVGNQLP IKSHRNSAGK LSFSWDNDSL LLQLKDGMRE
110 120 130 140 150
DMEVVYIGCL KEQIDTVEQD DVSQRLLENF KCVPAYIPPE LFTKYYHGFC
160 170 180 190 200
KQHLWPLFHY MLPLTPDLGG RFDRSLWQAY LSVNKIFADK VMEVISPDDD
210 220 230 240 250
FVWVHDYHLM VLPTFLRKRF NRVKLGFFLH SPFPSSEIYR TLPVRNELLR
260 270 280 290 300
ALLNADLIGF HTFDYARHFL SCCSRMLGLS YQSKRGTIGL EYYGRTVSIK
310 320 330 340 350
ILPVGIHISQ LQSILNLPET QTKVAELRDQ FLDQKVLLGV DDMDIFKGIS
360 370 380 390 400
LKLLAMEQLL TQHPEKRGRV VLVQIANPAR GRGKDVQEVQ SETEATVKRI
410 420 430 440 450
NEMFGRPGYQ PVVLIDTPLQ FFERIAYYVI AECCLVTAVR DGMNLIPYEY
460 470 480 490 500
IICRQGNPKL NETIGLDPSA AKKSMLVVSE FIGCSPSLSG AIRVNPWNID
510 520 530 540 550
AVTEAMDYAL IVSEAEKQMR HEKHHKYVST HDVAYWARSF IQDLERACGD
560 570 580 590 600
HVRKRCWGIG FGLGFRVVAL DPSFKKLSIE HIVSAYKRTK NRAILLDYDG
610 620 630 640 650
TMVQPGSIRT TPTRETIEIL NNLSSDPKNI VYLVSGKDRR TLTEWFSSCD
660 670 680 690 700
DLGLGAEHGY FIRPNDGTDW ETSSLVSGFE WKQIAEPVMR LYTETTDGST
710 720 730 740 750
IETKETALVW NYQFADPDFG SCQAKELMEH LESVLTNDPV SVKTGQQLVE
760 770 780 790 800
VKPQGVNKGL VAERLLTTMQ EKGKLLDFIL CVGDDRSDED MFEVIMSAKD
810 820 830 840 850
GPALSPVAEI FACTVGQKPS KAKYYLDDTA EIIRMLDGLA ATNTTISDQT
860
DSTATVPTKD LF
Length:862
Mass (Da):97,454
Last modified:March 18, 2008 - v2
Checksum:iADA155DB26DCB470
GO

Sequence cautioni

The sequence CAB10557 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78780 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97344 Genomic DNA Translation: CAB10557.1 Sequence problems.
AL161547 Genomic DNA Translation: CAB78780.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83948.1
CP002687 Genomic DNA Translation: ANM68026.1
BT005967 mRNA Translation: AAO64902.1
AK118703 mRNA Translation: BAC43297.1
PIRiH71447
RefSeqiNP_001329809.1, NM_001341241.1
NP_567538.1, NM_117886.3
UniGeneiAt.4501

Genome annotation databases

EnsemblPlantsiAT4G17770.1; AT4G17770.1; AT4G17770
AT4G17770.2; AT4G17770.2; AT4G17770
GeneIDi827498
GrameneiAT4G17770.1; AT4G17770.1; AT4G17770
AT4G17770.2; AT4G17770.2; AT4G17770
KEGGiath:AT4G17770

Entry informationi

Entry nameiTPS5_ARATH
AccessioniPrimary (citable) accession number: O23617
Secondary accession number(s): Q8GWQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: May 23, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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