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Protein

Peroxidase 41

Gene

PER41

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei62Transition state stabilizerPROSITE-ProRule annotation1
Active sitei66Proton acceptorPROSITE-ProRule annotation1
Metal bindingi67Calcium 1PROSITE-ProRule annotation1
Metal bindingi72Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Metal bindingi76Calcium 1PROSITE-ProRule annotation1
Binding sitei164Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi194Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi195Calcium 2PROSITE-ProRule annotation1
Metal bindingi242Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G17690-MONOMER.

Protein family/group databases

PeroxiBasei207. AtPrx41.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 41 (EC:1.11.1.7)
Short name:
Atperox P41
Gene namesi
Name:PER41
Synonyms:P41
Ordered Locus Names:At4g17690
ORF Names:dl4880w, FCAALL.96
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G17690.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002370721 – 326Peroxidase 41Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi35 ↔ 116PROSITE-ProRule annotation
Disulfide bondi68 ↔ 73PROSITE-ProRule annotation
Disulfide bondi122 ↔ 318PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi201 ↔ 228PROSITE-ProRule annotation
Glycosylationi234N-linked (GlcNAc...)Sequence analysis1
Glycosylationi286N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO23609.

Expressioni

Gene expression databases

GenevisibleiO23609. AT.

Interactioni

Protein-protein interaction databases

BioGridi12782. 1 interactor.
MINTiMINT-8070134.
STRINGi3702.AT4G17690.1.

Structurei

3D structure databases

ProteinModelPortaliO23609.
SMRiO23609.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INUY. Eukaryota.
ENOG410YDU7. LUCA.
HOGENOMiHOG000237556.
InParanoidiO23609.
KOiK00430.
OMAiVELYANN.
OrthoDBiEOG09360HTJ.
PhylomeDBiO23609.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVINVLFV VLVFVPSIYS APPPNLTKDY YQKTCPDFNK IVRETVTPKQ
60 70 80 90 100
GQQPTTAAGT LRLFFHDCFM EGCDASVLIA TNSFNKAERD DDLNESLPGD
110 120 130 140 150
AFDIVTRIKT ALELSCPGVV SCADILAQAT RDLVTMVGGP FYEVKLGRKD
160 170 180 190 200
GFESKAHKVK GNLPLANQSV PDMLSIFKKN GFTLKELVAL SGGHTIGFSH
210 220 230 240 250
CKEFSNRIFP KVDPELNAKF AGVLKDLCKN FETNKTMAAF LDPVTPGKFD
260 270 280 290 300
NMYFKNLKRG LGLLASDHIL FKDPSTRPFV ELYANNQTAF FEDFARAMEK
310 320
LGRVGVKGEK DGEVRRRCDH FNKLNV
Length:326
Mass (Da):36,198
Last modified:January 1, 1998 - v1
Checksum:i78B169B31BA85CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97344 Genomic DNA. Translation: CAB10549.1.
AL161547 Genomic DNA. Translation: CAB78772.1.
CP002687 Genomic DNA. Translation: AEE83934.1.
PIRiH71446.
RefSeqiNP_193504.1. NM_117877.2.

Genome annotation databases

EnsemblPlantsiAT4G17690.1; AT4G17690.1; AT4G17690.
GeneIDi827489.
GrameneiAT4G17690.1; AT4G17690.1; AT4G17690.
KEGGiath:AT4G17690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97344 Genomic DNA. Translation: CAB10549.1.
AL161547 Genomic DNA. Translation: CAB78772.1.
CP002687 Genomic DNA. Translation: AEE83934.1.
PIRiH71446.
RefSeqiNP_193504.1. NM_117877.2.

3D structure databases

ProteinModelPortaliO23609.
SMRiO23609.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12782. 1 interactor.
MINTiMINT-8070134.
STRINGi3702.AT4G17690.1.

Protein family/group databases

PeroxiBasei207. AtPrx41.

Proteomic databases

PaxDbiO23609.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G17690.1; AT4G17690.1; AT4G17690.
GeneIDi827489.
GrameneiAT4G17690.1; AT4G17690.1; AT4G17690.
KEGGiath:AT4G17690.

Organism-specific databases

TAIRiAT4G17690.

Phylogenomic databases

eggNOGiENOG410INUY. Eukaryota.
ENOG410YDU7. LUCA.
HOGENOMiHOG000237556.
InParanoidiO23609.
KOiK00430.
OMAiVELYANN.
OrthoDBiEOG09360HTJ.
PhylomeDBiO23609.

Enzyme and pathway databases

BioCyciARA:AT4G17690-MONOMER.

Miscellaneous databases

PROiO23609.

Gene expression databases

GenevisibleiO23609. AT.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER41_ARATH
AccessioniPrimary (citable) accession number: O23609
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.