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Protein

Peroxidase 41

Gene

PER41

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei62Transition state stabilizerPROSITE-ProRule annotation1
Active sitei66Proton acceptorPROSITE-ProRule annotation1
Metal bindingi67Calcium 1PROSITE-ProRule annotation1
Metal bindingi72Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi74Calcium 1PROSITE-ProRule annotation1
Metal bindingi76Calcium 1PROSITE-ProRule annotation1
Binding sitei164Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi194Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi195Calcium 2PROSITE-ProRule annotation1
Metal bindingi242Calcium 2PROSITE-ProRule annotation1
Metal bindingi245Calcium 2PROSITE-ProRule annotation1
Metal bindingi250Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G17690-MONOMER

Protein family/group databases

PeroxiBasei207 AtPrx41

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 41 (EC:1.11.1.7)
Short name:
Atperox P41
Gene namesi
Name:PER41
Synonyms:P41
Ordered Locus Names:At4g17690
ORF Names:dl4880w, FCAALL.96
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G17690
TAIRilocus:2129386 AT4G17690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000002370721 – 326Peroxidase 41Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi35 ↔ 116PROSITE-ProRule annotation
Disulfide bondi68 ↔ 73PROSITE-ProRule annotation
Disulfide bondi122 ↔ 318PROSITE-ProRule annotation
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi201 ↔ 228PROSITE-ProRule annotation
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi286N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO23609

Expressioni

Gene expression databases

ExpressionAtlasiO23609 baseline and differential
GenevisibleiO23609 AT

Interactioni

Protein-protein interaction databases

BioGridi12782, 1 interactor
STRINGi3702.AT4G17690.1

Structurei

3D structure databases

ProteinModelPortaliO23609
SMRiO23609
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410INUY Eukaryota
ENOG410YDU7 LUCA
HOGENOMiHOG000237556
InParanoidiO23609
KOiK00430
OMAiCKNFETN
OrthoDBiEOG09360HTJ
PhylomeDBiO23609

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23609-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVINVLFV VLVFVPSIYS APPPNLTKDY YQKTCPDFNK IVRETVTPKQ
60 70 80 90 100
GQQPTTAAGT LRLFFHDCFM EGCDASVLIA TNSFNKAERD DDLNESLPGD
110 120 130 140 150
AFDIVTRIKT ALELSCPGVV SCADILAQAT RDLVTMVGGP FYEVKLGRKD
160 170 180 190 200
GFESKAHKVK GNLPLANQSV PDMLSIFKKN GFTLKELVAL SGGHTIGFSH
210 220 230 240 250
CKEFSNRIFP KVDPELNAKF AGVLKDLCKN FETNKTMAAF LDPVTPGKFD
260 270 280 290 300
NMYFKNLKRG LGLLASDHIL FKDPSTRPFV ELYANNQTAF FEDFARAMEK
310 320
LGRVGVKGEK DGEVRRRCDH FNKLNV
Length:326
Mass (Da):36,198
Last modified:January 1, 1998 - v1
Checksum:i78B169B31BA85CE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97344 Genomic DNA Translation: CAB10549.1
AL161547 Genomic DNA Translation: CAB78772.1
CP002687 Genomic DNA Translation: AEE83934.1
PIRiH71446
RefSeqiNP_193504.1, NM_117877.2

Genome annotation databases

EnsemblPlantsiAT4G17690.1; AT4G17690.1; AT4G17690
GeneIDi827489
GrameneiAT4G17690.1; AT4G17690.1; AT4G17690
KEGGiath:AT4G17690

Similar proteinsi

Entry informationi

Entry nameiPER41_ARATH
AccessioniPrimary (citable) accession number: O23609
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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