Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

L-lactate dehydrogenase

Gene

dl4665w

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (LDH1), L-lactate dehydrogenase (At4g17260), L-lactate dehydrogenase (At4g17260), L-lactate dehydrogenase (dl4665w), L-lactate dehydrogenase
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei213Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • carboxylic acid metabolic process Source: InterPro
  • response to abscisic acid Source: TAIR
  • response to salt stress Source: TAIR

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-ATH-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:dl4665wImported
Ordered Locus Names:At4g17260Imported
ORF Names:Dl4665WImported, FCAALL.172Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G17260.
TAIRilocus:2130764. AT4G17260.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • plasma membrane Source: TAIR

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G17260.1.

Structurei

3D structure databases

SMRiO23569.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 180Ldh_1_NInterPro annotationAdd BLAST140
Domaini183 – 346Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00016.
OMAiMDLMQTA.
OrthoDBiEOG09360DKP.

Family and domain databases

HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

O23569-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKNASTSSL KDLGPSGLDL TSAFFKPIHN SDPSLPSNRR TKVSVVGVGN
60 70 80 90 100
VGMAIAQTIL TQDLADEIAL VDAKPDKLRG EMLDLQHAAA FLPRTKITAS
110 120 130 140 150
VDYEVTAGSD LCIVTAGARQ NPGESRLNLL QRNVALFRHI IPPLAKASPD
160 170 180 190 200
SILIIVSNPV DVLTYVAWKL SGFPVNRVLG SGTNLDSSRF RFLIADHLDV
210 220 230 240 250
NAQDVQAFIV GEHGDSSVAL WSSISVGGIP VLSFLEKNQI AYEKQTLEDI
260 270 280 290 300
HQAVVGSAYE VIGLKGYTSW AIGYSVANLA RTILRDQRKI HPVTVLARGF
310 320 330 340 350
YGVDGGDVFL SLPALLGRNG VVAVTNVHMT DEEAEKLQKS AKTILEMQSQ

LGL
Length:353
Mass (Da):37,950
Last modified:January 1, 1998 - v1
Checksum:iF8467FD4BC298F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT028958 mRNA. Translation: ABI54333.1.
CP002687 Genomic DNA. Translation: AEE83871.1.
Z97343 Genomic DNA. Translation: CAB10507.1.
AL161546 Genomic DNA. Translation: CAB78729.1.
PIRiF71441.
RefSeqiNP_193459.1. NM_117832.4.
UniGeneiAt.27760.

Genome annotation databases

EnsemblPlantsiAT4G17260.1; AT4G17260.1; AT4G17260.
GeneIDi827440.
GrameneiAT4G17260.1; AT4G17260.1; AT4G17260.
KEGGiath:AT4G17260.

Similar proteinsi

Entry informationi

Entry nameiO23569_ARATH
AccessioniPrimary (citable) accession number: O23569
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: August 30, 2017
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported