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Protein

Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1

Gene

SNC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Disease resistance protein of the TIR-NB-LRR-type. Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Regulated by RNA silencing. Expression regulated by MOS1 at chromatin level. Negatively regulated at the transcript level by BON1. Nuclear localization of SNC1 is essential for its activity (PubMed:22454454). ABA deficiency can rescue high-temperature inhibition of SNC1-mediated defense responses (PubMed:22454454).3 Publications

GO - Molecular functioni

  • ADP binding Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • nucleotide binding Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • response to auxin Source: TAIR
  • systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Plant defense

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1
Short name:
AtSNC1
Alternative name(s):
Disease resistance RPP5-like protein
Gene namesi
Name:SNC1
Synonyms:BAL
Ordered Locus Names:At4g16890
ORF Names:dl4475c, FCAALL.51
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G16890.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • endoplasmic reticulum Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi561E → K in snc1; constitutive disease resistance. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003994671 – 1310Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1Add BLAST1310

Proteomic databases

PaxDbiO23530.

PTM databases

iPTMnetiO23530.

Expressioni

Tissue specificityi

Expressed in guard cells and epidermal cells, but not detected in mesophyll cells.1 Publication

Inductioni

Up-regulated by salicylic acid and in mutants defective in RNA silencing. Down-regulated by high temperature.1 Publication

Gene expression databases

GenevisibleiO23530. AT.

Interactioni

Subunit structurei

Interacts (via TIR domain) with TPR1 (PubMed:20647385). Interacts with EDS1 (PubMed:22158819). Interacts with SRFR1 (PubMed:21079790). Interacts with HSP90-3 (PubMed:24889324). Binds to MORC1/CRT1 (PubMed:20332379).5 Publications

Protein-protein interaction databases

BioGridi12690. 7 interactors.
DIPiDIP-59360N.
STRINGi3702.AT4G16890.1.

Structurei

3D structure databases

ProteinModelPortaliO23530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 156TIRPROSITE-ProRule annotationAdd BLAST138
Domaini196 – 451NB-ARCAdd BLAST256
Repeati554 – 576LRR 1Add BLAST23
Repeati577 – 598LRR 2Add BLAST22
Repeati600 – 621LRR 3Add BLAST22
Repeati622 – 645LRR 4Add BLAST24
Repeati647 – 668LRR 5Add BLAST22
Repeati670 – 691LRR 6Add BLAST22
Repeati692 – 715LRR 7Add BLAST24
Repeati781 – 805LRR 8Add BLAST25
Repeati807 – 828LRR 9Add BLAST22
Repeati829 – 851LRR 10Add BLAST23
Repeati852 – 875LRR 11Add BLAST24
Repeati877 – 895LRR 12Add BLAST19
Repeati918 – 939LRR 13Add BLAST22
Repeati940 – 962LRR 14Add BLAST23
Repeati964 – 985LRR 15Add BLAST22
Repeati1008 – 1029LRR 16Add BLAST22
Repeati1030 – 1052LRR 17Add BLAST23
Repeati1075 – 1096LRR 18Add BLAST22
Repeati1097 – 1121LRR 19Add BLAST25
Repeati1123 – 1143LRR 20Add BLAST21
Repeati1177 – 1201LRR 21Add BLAST25

Sequence similaritiesi

Belongs to the disease resistance NB-LRR family.Curated
Contains 21 LRR (leucine-rich) repeats.Curated
Contains 1 NB-ARC domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGA8. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000064702.
InParanoidiO23530.
OMAiTSEEDIN.
OrthoDBiEOG09360FZ0.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07725. LRR_3. 2 hits.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 2 (identifier: O23530-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDTSKDDDM EIASSSGSRR YDVFPSFRGE DVRDSFLSHL LKELRGKAIT
60 70 80 90 100
FIDDEIERSR SIGPELLSAI KESRIAIVIF SKNYASSTWC LNELVEIHKC
110 120 130 140 150
YTNLNQMVIP IFFHVDASEV KKQTGEFGKV FEETCKAKSE DEKQSWKQAL
160 170 180 190 200
AAVAVMAGYD LRKWPSEAAM IEELAEDVLR KTMTPSDDFG DLVGIENHIE
210 220 230 240 250
AIKSVLCLES KEARIMVGIW GQSGIGKSTI GRALYSKLSI QFHHRAFITY
260 270 280 290 300
KSTSGSDVSG MKLRWEKELL SEILGQKDIK IEHFGVVEQR LKQQKVLILL
310 320 330 340 350
DDVDSLEFLK TLVGKAEWFG SGSRIIVITQ DRQLLKAHEI DLIYEVEFPS
360 370 380 390 400
EHLALTMLCR SAFGKDSPPD DFKELAFEVA KLAGNLPLGL SVLGSSLKGR
410 420 430 440 450
TKEWWMEMMP RLRNGLNGDI MKTLRVSYDR LHQKDQDMFL YIACLFNGFE
460 470 480 490 500
VSYVKDLLKD NVGFTMLTEK SLIRITPDGY IEMHNLLEKL GREIDRAKSK
510 520 530 540 550
GNPGKRRFLT NFEDIHEVVT EKTGTETLLG IRLPFEEYFS TRPLLIDKES
560 570 580 590 600
FKGMRNLQYL EIGYYGDLPQ SLVYLPLKLR LLDWDDCPLK SLPSTFKAEY
610 620 630 640 650
LVNLIMKYSK LEKLWEGTLP LGSLKEMNLR YSNNLKEIPD LSLAINLEEL
660 670 680 690 700
DLVGCKSLVT LPSSIQNATK LIYLDMSDCK KLESFPTDLN LESLEYLNLT
710 720 730 740 750
GCPNLRNFPA IKMGCSDVDF PEGRNEIVVE DCFWNKNLPA GLDYLDCLTR
760 770 780 790 800
CMPCEFRPEQ LAFLNVRGYK HEKLWEGIQS LGSLEGMDLS ESENLTEIPD
810 820 830 840 850
LSKATKLESL ILNNCKSLVT LPSTIGNLHR LVRLEMKECT GLEVLPTDVN
860 870 880 890 900
LSSLETLDLS GCSSLRSFPL ISTNIVWLYL ENTAIEEIPS TIGNLHRLVR
910 920 930 940 950
LEMKKCTGLE VLPTDVNLSS LETLDLSGCS SLRSFPLISE SIKWLYLENT
960 970 980 990 1000
AIEEIPDLSK ATNLKNLKLN NCKSLVTLPT TIGNLQKLVS FEMKECTGLE
1010 1020 1030 1040 1050
VLPIDVNLSS LMILDLSGCS SLRTFPLIST NIVWLYLENT AIEEIPSTIG
1060 1070 1080 1090 1100
NLHRLVKLEM KECTGLEVLP TDVNLSSLMI LDLSGCSSLR TFPLISTRIE
1110 1120 1130 1140 1150
CLYLQNTAIE EVPCCIEDFT RLTVLMMYCC QRLKTISPNI FRLTRLELAD
1160 1170 1180 1190 1200
FTDCRGVIKA LSDATVVATM EDHVSCVPLS ENIEYIWDKL YHLPSKLNFN
1210 1220 1230 1240 1250
DVEFKFCCSN RIKECGVRLM YVSQEENNQQ TTRSEKRMRM TSGTSEEDIN
1260 1270 1280 1290 1300
LPYGLIVADT GLAALNMELS LGQGEPSSST SLEGEALCVD YMITEEQDKG
1310
IPILFPVSGN
Note: Produced by alternative splicing.Curated
Length:1,310
Mass (Da):147,950
Last modified:December 9, 2015 - v4
Checksum:i6AA9A026C82039F7
GO
Isoform 1 (identifier: O23530-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Note: Produced by alternative initiation. A number of isoforms are also produced by alternative splicing.Curated1 Publication
Show »
Length:1,301
Mass (Da):146,911
Checksum:iE2A02A8CB81C46FA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579821 – 9Missing in isoform 1. Curated9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97342 Genomic DNA. Translation: CAB46044.1.
AL161545 Genomic DNA. Translation: CAB80960.1.
CP002687 Genomic DNA. Translation: AEE83820.1.
PIRiD85188.
H71436.
UniGeneiAt.43451.
At.43768.

Genome annotation databases

EnsemblPlantsiAT4G16890.1; AT4G16890.1; AT4G16890. [O23530-1]
GrameneiAT4G16890.1; AT4G16890.1; AT4G16890.
KEGGiath:AT4G16890.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97342 Genomic DNA. Translation: CAB46044.1.
AL161545 Genomic DNA. Translation: CAB80960.1.
CP002687 Genomic DNA. Translation: AEE83820.1.
PIRiD85188.
H71436.
UniGeneiAt.43451.
At.43768.

3D structure databases

ProteinModelPortaliO23530.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12690. 7 interactors.
DIPiDIP-59360N.
STRINGi3702.AT4G16890.1.

PTM databases

iPTMnetiO23530.

Proteomic databases

PaxDbiO23530.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G16890.1; AT4G16890.1; AT4G16890. [O23530-1]
GrameneiAT4G16890.1; AT4G16890.1; AT4G16890.
KEGGiath:AT4G16890.

Organism-specific databases

TAIRiAT4G16890.

Phylogenomic databases

eggNOGiENOG410IGA8. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000064702.
InParanoidiO23530.
OMAiTSEEDIN.
OrthoDBiEOG09360FZ0.

Miscellaneous databases

PROiO23530.

Gene expression databases

GenevisibleiO23530. AT.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.40.50.300. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR011713. Leu-rich_rpt_3.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF07725. LRR_3. 2 hits.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNC1_ARATH
AccessioniPrimary (citable) accession number: O23530
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: December 9, 2015
Last modified: November 30, 2016
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

A gain-of-function mutant in SNC1 resulting from a point mutation leads to a dwarf and curled-leaf phenotype and a constitutive disease resistance in the absence of cell death.
The phenotypically unstable bal phenotype is caused by a duplication of the locus carrying SNC1 followed by a hypermutation of the gene.
SNC1 is not found in cv. Landsberg erecta, cv. No-0, and cv. Wassilewskija and is probably unique to cv. Columbia (PubMed:15031411). Cv. RLD encodes a non-functional truncated SNC1 protein lacking most of the LRR domain (PubMed:21079790).
MOS2, MOS2H, MOS12 and the MOS4-associated complex (MAC) are required for the proper splicing of R genes and contribute in the alternative splicing of SNC1.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.