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Protein

Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1

Gene

SNC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Disease resistance protein of the TIR-NB-LRR-type. Part of the RPP5 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. Regulated by RNA silencing. Expression regulated by MOS1 at chromatin level. Negatively regulated at the transcript level by BON1. Nuclear localization of SNC1 is essential for its activity (PubMed:22454454). ABA deficiency can rescue high-temperature inhibition of SNC1-mediated defense responses (PubMed:22454454).3 Publications

Miscellaneous

A gain-of-function mutant in SNC1 resulting from a point mutation leads to a dwarf and curled-leaf phenotype and a constitutive disease resistance in the absence of cell death.
The phenotypically unstable bal phenotype is caused by a duplication of the locus carrying SNC1 followed by a hypermutation of the gene.
SNC1 is not found in cv. Landsberg erecta, cv. No-0, and cv. Wassilewskija and is probably unique to cv. Columbia (PubMed:15031411). Cv. RLD encodes a non-functional truncated SNC1 protein lacking most of the LRR domain (PubMed:21079790).
MOS2, MOS2H, MOS12 and the MOS4-associated complex (MAC) are required for the proper splicing of R genes and contribute in the alternative splicing of SNC1.2 Publications

GO - Molecular functioni

  • ADP binding Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • nucleotide binding Source: TAIR

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • response to auxin Source: TAIR
  • systemic acquired resistance, salicylic acid mediated signaling pathway Source: TAIR

Keywordsi

Biological processPlant defense
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 11 Publication
Short name:
AtSNC11 Publication
Alternative name(s):
Disease resistance RPP5-like protein
Gene namesi
Name:SNC11 Publication
Synonyms:BAL1 Publication
Ordered Locus Names:At4g16890Imported
ORF Names:dl4475cImported, FCAALL.51Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G16890.
TAIRilocus:2129236. AT4G16890.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi561E → K in snc1; constitutive disease resistance. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003994671 – 1437Protein SUPPRESSOR OF npr1-1, CONSTITUTIVE 1Add BLAST1437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Isoform 1 (identifier: O23530-1)
Modified residuei1N-acetylmethionine1 Publication1

Post-translational modificationi

Isoform 2: Met-1 is specifically acetylated by N-terminal acetyltransferase complex A (NatA). The NatA-mediated acetylation serves as a degradation signal.1 Publication
Isoform 1: Met-1 is specifically acetylated by N-terminal acetyltransferase complex B (NatB). The NatB-mediated acetylation stabilizes SNC1.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiO23530.

PTM databases

iPTMnetiO23530.

Expressioni

Tissue specificityi

Expressed in guard cells and epidermal cells, but not detected in mesophyll cells.1 Publication

Inductioni

Up-regulated by salicylic acid and in mutants defective in RNA silencing. Down-regulated by high temperature.1 Publication

Gene expression databases

ExpressionAtlasiO23530. baseline and differential.
GenevisibleiO23530. AT.

Interactioni

Subunit structurei

Homodimer (PubMed:27818198). Interacts (via TIR domain) with TPR1 (PubMed:20647385). Interacts with EDS1 (PubMed:22158819). Interacts with SRFR1 (PubMed:21079790). Interacts with HSP90-3 (PubMed:24889324). Binds to MORC1/CRT1 (PubMed:20332379). Interacts with TRAF1B (PubMed:26867179).7 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi12690. 7 interactors.
DIPiDIP-59360N.
IntActiO23530. 3 interactors.
STRINGi3702.AT4G16890.1.

Structurei

Secondary structure

11437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 26Combined sources6
Helixi29 – 32Combined sources4
Turni33 – 35Combined sources3
Helixi36 – 45Combined sources10
Turni46 – 48Combined sources3
Turni68 – 72Combined sources5
Beta strandi73 – 80Combined sources8
Helixi84 – 86Combined sources3
Helixi88 – 104Combined sources17
Beta strandi107 – 115Combined sources9
Helixi117 – 122Combined sources6
Helixi125 – 135Combined sources11
Helixi140 – 154Combined sources15
Helixi161 – 163Combined sources3
Helixi167 – 182Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H3CX-ray2.60A/B17-190[»]
5TECX-ray2.20A/B17-190[»]
ProteinModelPortaliO23530.
SMRiO23530.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 156TIRPROSITE-ProRule annotationAdd BLAST138
Repeati554 – 576LRR 1Sequence analysisAdd BLAST23
Repeati577 – 598LRR 2Sequence analysisAdd BLAST22
Repeati600 – 621LRR 3Sequence analysisAdd BLAST22
Repeati622 – 645LRR 4Sequence analysisAdd BLAST24
Repeati647 – 668LRR 5Sequence analysisAdd BLAST22
Repeati670 – 691LRR 6Sequence analysisAdd BLAST22
Repeati692 – 715LRR 7Sequence analysisAdd BLAST24
Repeati781 – 805LRR 8Sequence analysisAdd BLAST25
Repeati807 – 828LRR 9Sequence analysisAdd BLAST22
Repeati829 – 851LRR 10Sequence analysisAdd BLAST23
Repeati852 – 875LRR 11Sequence analysisAdd BLAST24
Repeati877 – 895LRR 12Sequence analysisAdd BLAST19
Repeati897 – 918LRR 13Sequence analysisAdd BLAST22
Repeati919 – 939LRR 14Sequence analysisAdd BLAST21
Repeati940 – 962LRR 15Sequence analysisAdd BLAST23
Repeati964 – 985LRR 16Sequence analysisAdd BLAST22
Repeati1009 – 1029LRR 17Sequence analysisAdd BLAST21
Repeati1030 – 1052LRR 18Sequence analysisAdd BLAST23
Repeati1054 – 1075LRR 19Sequence analysisAdd BLAST22
Repeati1076 – 1096LRR 20Sequence analysisAdd BLAST21
Repeati1097 – 1121LRR 21Sequence analysisAdd BLAST25
Repeati1123 – 1143LRR 22Sequence analysisAdd BLAST21
Repeati1161 – 1185LRR 23Sequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the disease resistance NB-LRR family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IGA8. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000064702.
InParanoidiO23530.
OrthoDBiEOG09360FZ0.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 6 hits.
InterProiView protein in InterPro
IPR011713. Leu-rich_rpt_3.
IPR032675. LRR_dom_sf.
IPR002182. NB-ARC.
IPR027417. P-loop_NTPase.
IPR000157. TIR_dom.
IPR035897. Toll_tir_struct_dom_sf.
IPR036390. WH_DNA-bd_sf.
PfamiView protein in Pfam
PF07725. LRR_3. 2 hits.
PF00931. NB-ARC. 1 hit.
PF01582. TIR. 1 hit.
SMARTiView protein in SMART
SM00255. TIR. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS50104. TIR. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 2 (identifier: O23530-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDTSKDDDM EIASSSGSRR YDVFPSFRGE DVRDSFLSHL LKELRGKAIT
60 70 80 90 100
FIDDEIERSR SIGPELLSAI KESRIAIVIF SKNYASSTWC LNELVEIHKC
110 120 130 140 150
YTNLNQMVIP IFFHVDASEV KKQTGEFGKV FEETCKAKSE DEKQSWKQAL
160 170 180 190 200
AAVAVMAGYD LRKWPSEAAM IEELAEDVLR KTMTPSDDFG DLVGIENHIE
210 220 230 240 250
AIKSVLCLES KEARIMVGIW GQSGIGKSTI GRALYSKLSI QFHHRAFITY
260 270 280 290 300
KSTSGSDVSG MKLRWEKELL SEILGQKDIK IEHFGVVEQR LKQQKVLILL
310 320 330 340 350
DDVDSLEFLK TLVGKAEWFG SGSRIIVITQ DRQLLKAHEI DLIYEVEFPS
360 370 380 390 400
EHLALTMLCR SAFGKDSPPD DFKELAFEVA KLAGNLPLGL SVLGSSLKGR
410 420 430 440 450
TKEWWMEMMP RLRNGLNGDI MKTLRVSYDR LHQKDQDMFL YIACLFNGFE
460 470 480 490 500
VSYVKDLLKD NVGFTMLTEK SLIRITPDGY IEMHNLLEKL GREIDRAKSK
510 520 530 540 550
GNPGKRRFLT NFEDIHEVVT EKTGTETLLG IRLPFEEYFS TRPLLIDKES
560 570 580 590 600
FKGMRNLQYL EIGYYGDLPQ SLVYLPLKLR LLDWDDCPLK SLPSTFKAEY
610 620 630 640 650
LVNLIMKYSK LEKLWEGTLP LGSLKEMNLR YSNNLKEIPD LSLAINLEEL
660 670 680 690 700
DLVGCKSLVT LPSSIQNATK LIYLDMSDCK KLESFPTDLN LESLEYLNLT
710 720 730 740 750
GCPNLRNFPA IKMGCSDVDF PEGRNEIVVE DCFWNKNLPA GLDYLDCLTR
760 770 780 790 800
CMPCEFRPEQ LAFLNVRGYK HEKLWEGIQS LGSLEGMDLS ESENLTEIPD
810 820 830 840 850
LSKATKLESL ILNNCKSLVT LPSTIGNLHR LVRLEMKECT GLEVLPTDVN
860 870 880 890 900
LSSLETLDLS GCSSLRSFPL ISTNIVWLYL ENTAIEEIPS TIGNLHRLVR
910 920 930 940 950
LEMKKCTGLE VLPTDVNLSS LETLDLSGCS SLRSFPLISE SIKWLYLENT
960 970 980 990 1000
AIEEIPDLSK ATNLKNLKLN NCKSLVTLPT TIGNLQKLVS FEMKECTGLE
1010 1020 1030 1040 1050
VLPIDVNLSS LMILDLSGCS SLRTFPLIST NIVWLYLENT AIEEIPSTIG
1060 1070 1080 1090 1100
NLHRLVKLEM KECTGLEVLP TDVNLSSLMI LDLSGCSSLR TFPLISTRIE
1110 1120 1130 1140 1150
CLYLQNTAIE EVPCCIEDFT RLTVLMMYCC QRLKTISPNI FRLTRLELAD
1160 1170 1180 1190 1200
FTDCRGVIKA LSDATVVATM EDHVSCVPLS ENIEYIWDKL YRVAYLQEHF
1210 1220 1230 1240 1250
SFRNCFKLDR DARELILRSC FKPVALPGEE IPKYFTYRAY GDSLTVIVPQ
1260 1270 1280 1290 1300
SSLSQNFLRF KACVVVEPLS KGKGFYPFLK VNVGFNGKQY QKSFSKDAEL
1310 1320 1330 1340 1350
ELCKTDHLFF CSFKFRSEDL PSKLNFNDVE FKFCCSNRIK ECGVRLMYVS
1360 1370 1380 1390 1400
QEENNQQTTR SEKRMRMTSG TSEEDINLPY GLIVADTGLA ALNMELSLGQ
1410 1420 1430
GEPSSSTSLE GEALCVDYMI TEEQDKGIPI LFPVSGN
Length:1,437
Mass (Da):162,713
Last modified:March 15, 2017 - v5
Checksum:iE1DFAC43DAD04058
GO
Isoform 1 (identifier: O23530-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: Missing.

Show »
Length:1,436
Mass (Da):162,582
Checksum:i9450AE53326257B1
GO

Sequence cautioni

The sequence CAB46044 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80960 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0579821Missing in isoform 1. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97342 Genomic DNA. Translation: CAB46044.1. Sequence problems.
AL161545 Genomic DNA. Translation: CAB80960.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83820.2.
PIRiD85188.
H71436.
RefSeqiNP_001319970.1. NM_001341145.1. [O23530-2]
UniGeneiAt.43451.
At.43768.

Genome annotation databases

EnsemblPlantsiAT4G16890.1; AT4G16890.1; AT4G16890. [O23530-2]
GeneIDi827397.
GrameneiAT4G16890.1; AT4G16890.1; AT4G16890.
KEGGiath:AT4G16890.

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiSNC1_ARATH
AccessioniPrimary (citable) accession number: O23530
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: March 15, 2017
Last modified: November 22, 2017
This is version 136 of the entry and version 5 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families