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Protein

Oligopeptide transporter 3

Gene

OPT3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the translocation of tetra- and pentapeptides across the cellular membrane in an energy-dependent manner. Acts also as a metal transporter that could be a component of the copper transport machinery. Essential for early embryo development.3 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Peptide transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Oligopeptide transporter 3
Short name:
AtOPT3
Gene namesi
Name:OPT3
Ordered Locus Names:At4g16370
ORF Names:dl4215c, FCAALL.72
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G16370.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei45 – 6521HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Transmembranei153 – 17321HelicalSequence analysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence analysisAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei289 – 30921HelicalSequence analysisAdd
BLAST
Transmembranei357 – 37721HelicalSequence analysisAdd
BLAST
Transmembranei418 – 43821HelicalSequence analysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence analysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence analysisAdd
BLAST
Transmembranei532 – 55221HelicalSequence analysisAdd
BLAST
Transmembranei604 – 62421HelicalSequence analysisAdd
BLAST
Transmembranei629 – 64921HelicalSequence analysisAdd
BLAST
Transmembranei650 – 67021HelicalSequence analysisAdd
BLAST
Transmembranei681 – 70121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Oligopeptide transporter 3PRO_0000213780Add
BLAST

Proteomic databases

PaxDbiO23482.
PRIDEiO23482.

Expressioni

Tissue specificityi

Strong expression in flowers, leaves and roots. Preferentially expressed in the vascular tissues of seedlings and mature plants as well as in pollen and developing embryos.2 Publications

Developmental stagei

Expressed 2 to 4 hours after fertilization in the embryo sac and subsequently in developing maternal tissues. By the globular stage, expression is observed in the developing endosperm, integument layers, the embryo proper, and the suspensor of the developing embryo. From the heart stage onward, expression observed in the embryo but neither in the suspensor nor in the endosperm and integument tissues.1 Publication

Inductioni

Highly induced by iron, copper and manganese deficiencies.1 Publication

Gene expression databases

GenevisibleiO23482. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G16370.1.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2262. Eukaryota.
ENOG410XNZC. LUCA.
HOGENOMiHOG000166970.
InParanoidiO23482.

Family and domain databases

InterProiIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamiPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.

Sequencei

Sequence statusi: Complete.

O23482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAEKATDKT NVHLSSDHER CPVEEVALVV PETDDPSLPV MTFRAWFLGL
60 70 80 90 100
TSCVLLIFLN TFFTYRTQPL TISAILMQIA VLPIGKFMAR TLPTTSHNLL
110 120 130 140 150
GWSFSLNPGP FNIKEHVIIT IFANCGVAYG GGDAYSIGAI TVMKAYYKQS
160 170 180 190 200
LSFICGLFIV LTTQILGYGW AGILRRYLVD PVDMWWPSNL AQVSLFRALH
210 220 230 240 250
EKENKSKGLT RMKFFLVALG ASFIYYALPG YLFPILTFFS WVCWAWPNSI
260 270 280 290 300
TAQQVGSGYH GLGVGAFTLD WAGISAYHGS PLVAPWSSIL NVGVGFIMFI
310 320 330 340 350
YIIVPVCYWK FNTFDARKFP IFSNQLFTTS GQKYDTTKIL TPQFDLDIGA
360 370 380 390 400
YNNYGKLYLS PLFALSIGSG FARFTATLTH VALFNGRDIW KQTWSAVNTT
410 420 430 440 450
KLDIHGKLMQ SYKKVPEWWF YILLAGSVAM SLLMSFVWKE SVQLPWWGML
460 470 480 490 500
FAFALAFIVT LPIGVIQATT NQQPGYDIIG QFIIGYILPG KPIANLIFKI
510 520 530 540 550
YGRISTVHAL SFLADLKLGH YMKIPPRCMY TAQLVGTVVA GVVNLGVAWW
560 570 580 590 600
MLESIQDICD IEGDHPNSPW TCPKYRVTFD ASVIWGLIGP RRLFGPGGMY
610 620 630 640 650
RNLVWLFLIG AVLPVPVWAL SKIFPNKKWI PLINIPVISY GFAGMPPATP
660 670 680 690 700
TNIASWLVTG TIFNYFVFNY HKRWWQKYNY VLSAALDAGT AFMGVLLFFA
710 720 730
LQNAGHDLKW WGTEVDHCPL ASCPTAPGIK AKGCPVF
Length:737
Mass (Da):82,441
Last modified:May 3, 2011 - v3
Checksum:i8E3A03673C0C12D6
GO

Sequence cautioni

The sequence CAB10414.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAB78679.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451A → T in AAK96781 (PubMed:14593172).Curated
Sequence conflicti81 – 811V → G in CAB10414 (PubMed:9461215).Curated
Sequence conflicti81 – 811V → G in CAB78679 (PubMed:10617198).Curated
Sequence conflicti239 – 2391F → S in CAB10414 (PubMed:9461215).Curated
Sequence conflicti239 – 2391F → S in CAB78679 (PubMed:10617198).Curated
Sequence conflicti322 – 3221F → S in CAB10414 (PubMed:9461215).Curated
Sequence conflicti322 – 3221F → S in CAB78679 (PubMed:10617198).Curated
Sequence conflicti527 – 5271R → P in CAB10414 (PubMed:9461215).Curated
Sequence conflicti527 – 5271R → P in CAB78679 (PubMed:10617198).Curated
Sequence conflicti605 – 6062WL → GF in CAB10414 (PubMed:9461215).Curated
Sequence conflicti605 – 6062WL → GF in CAB78679 (PubMed:10617198).Curated
Sequence conflicti605 – 6051W → G in AEE83738 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97341 Genomic DNA. Translation: CAB10414.1. Sequence problems.
AL161543 Genomic DNA. Translation: CAB78679.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83738.1.
BT002023 mRNA. Translation: AAN72034.1.
AY054590 mRNA. Translation: AAK96781.1.
PIRiD71430.
RefSeqiNP_567493.5. NM_117732.6.
UniGeneiAt.4409.

Genome annotation databases

EnsemblPlantsiAT4G16370.1; AT4G16370.1; AT4G16370.
GeneIDi827332.
GrameneiAT4G16370.1; AT4G16370.1; AT4G16370.
KEGGiath:AT4G16370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97341 Genomic DNA. Translation: CAB10414.1. Sequence problems.
AL161543 Genomic DNA. Translation: CAB78679.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83738.1.
BT002023 mRNA. Translation: AAN72034.1.
AY054590 mRNA. Translation: AAK96781.1.
PIRiD71430.
RefSeqiNP_567493.5. NM_117732.6.
UniGeneiAt.4409.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G16370.1.

Proteomic databases

PaxDbiO23482.
PRIDEiO23482.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G16370.1; AT4G16370.1; AT4G16370.
GeneIDi827332.
GrameneiAT4G16370.1; AT4G16370.1; AT4G16370.
KEGGiath:AT4G16370.

Organism-specific databases

TAIRiAT4G16370.

Phylogenomic databases

eggNOGiKOG2262. Eukaryota.
ENOG410XNZC. LUCA.
HOGENOMiHOG000166970.
InParanoidiO23482.

Miscellaneous databases

PROiO23482.

Gene expression databases

GenevisibleiO23482. AT.

Family and domain databases

InterProiIPR004648. Oligpept_transpt.
IPR004813. OPT.
[Graphical view]
PfamiPF03169. OPT. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00727. ISP4_OPT. 1 hit.
TIGR00728. OPT_sfam. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana."
    Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.
    , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.
    Nature 391:485-488(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION, SEQUENCE REVISION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "An oligopeptide transporter gene family in Arabidopsis."
    Koh S., Wiles A.M., Sharp J.S., Naider F.R., Becker J.M., Stacey G.
    Plant Physiol. 128:21-29(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, NOMENCLATURE, TISSUE SPECIFICITY.
  6. "AtOPT3, a member of the oligopeptide transporter family, is essential for embryo development in Arabidopsis."
    Stacey M.G., Koh S., Becker J., Stacey G.
    Plant Cell 14:2799-2811(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis."
    Wintz H., Fox T., Wu Y.-Y., Feng V., Chen W., Chang H.-S., Zhu T., Vulpe C.D.
    J. Biol. Chem. 278:47644-47653(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.

Entry informationi

Entry nameiOPT3_ARATH
AccessioniPrimary (citable) accession number: O23482
Secondary accession number(s): F4JLS9, Q8H0V0, Q940I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: May 3, 2011
Last modified: June 8, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.