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Protein

Peroxidase 40

Gene

PER40

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei86Transition state stabilizerPROSITE-ProRule annotation1
Active sitei90Proton acceptorPROSITE-ProRule annotation1
Metal bindingi91Calcium 1PROSITE-ProRule annotation1
Metal bindingi94Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi96Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi98Calcium 1PROSITE-ProRule annotation1
Metal bindingi100Calcium 1PROSITE-ProRule annotation1
Binding sitei187Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi217Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi218Calcium 2PROSITE-ProRule annotation1
Metal bindingi269Calcium 2PROSITE-ProRule annotation1
Metal bindingi272Calcium 2PROSITE-ProRule annotation1
Metal bindingi277Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G16270-MONOMER

Protein family/group databases

PeroxiBasei206 AtPrx40

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 40 (EC:1.11.1.7)
Short name:
Atperox P40
Gene namesi
Name:PER40
Synonyms:P40
Ordered Locus Names:At4g16270
ORF Names:dl4175w, FCAALL.329
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G16270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002370622 – 348Peroxidase 40Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 139PROSITE-ProRule annotation
Disulfide bondi92 ↔ 97PROSITE-ProRule annotation
Disulfide bondi145 ↔ 344PROSITE-ProRule annotation
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi224 ↔ 256PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO23474

Expressioni

Gene expression databases

ExpressionAtlasiO23474 baseline and differential
GenevisibleiO23474 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G16270.1

Structurei

3D structure databases

ProteinModelPortaliO23474
SMRiO23474
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHXA Eukaryota
ENOG410YEGN LUCA
HOGENOMiHOG000237557
InParanoidiO23474
KOiK00430
OrthoDBiEOG09360IR9
PhylomeDBiO23474

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23474-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNLFNLFLM FFFAMPILSL SENPTNFSES CEDGSGETGS SFGIGFDLVL
60 70 80 90 100
DFGLYRNSCP EAESIVYSWV ETTVLEDPRM AASLLRLHFH DCFVNGCDAS
110 120 130 140 150
VLLDDTEGLV GEKTAPPNLN SLRGFEVIDS IKSDIESVCP ETVSCADILA
160 170 180 190 200
MAARDSVVVS GGPRWEVEVG RKDSRTASKQ AATNGLPSPN STVSTLISTF
210 220 230 240 250
QNLGLSQTDM VALSGGHTLG KARCTSFTAR LQPLQTGQPA NHGDNLEFLE
260 270 280 290 300
SLQQLCSTVG PSVGITQLDL VTPSTFDNQY YVNLLSGEGL LPSDQALAVQ
310 320 330 340
DPGTRAIVET YATDQSVFFE DFKNAMVKMG GIPGGSNSEI RKNCRMIN
Length:348
Mass (Da):37,460
Last modified:December 6, 2002 - v2
Checksum:i1B438813818178E5
GO

Sequence cautioni

The sequence BAD43424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAD43745 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAB10406 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78669 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97340 Genomic DNA Translation: CAB10406.1 Sequence problems.
AL161543 Genomic DNA Translation: CAB78669.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83724.2
BT011747 mRNA Translation: AAS49110.1
AK175661 mRNA Translation: BAD43424.1 Different initiation.
AK175982 mRNA Translation: BAD43745.1 Different initiation.
RefSeqiNP_193362.3, NM_117724.4
UniGeneiAt.50347
At.67828

Genome annotation databases

EnsemblPlantsiAT4G16270.1; AT4G16270.1; AT4G16270
GeneIDi827322
GrameneiAT4G16270.1; AT4G16270.1; AT4G16270
KEGGiath:AT4G16270

Similar proteinsi

Entry informationi

Entry nameiPER40_ARATH
AccessioniPrimary (citable) accession number: O23474
Secondary accession number(s): F4JLR5, Q53XE3, Q67ZY5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: December 6, 2002
Last modified: April 25, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health