Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

O23390

- BARS1_ARATH

UniProt

O23390 - BARS1_ARATH

Protein

Baruol synthase

Gene

BARS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Converts oxidosqualene to baruol (90%) and 22 minor products.1 Publication

    Catalytic activityi

    (3S)-2,3-epoxy-2,3-dihydrosqualene = baruol.1 Publication

    GO - Molecular functioni

    1. baruol synthase activity Source: TAIR

    GO - Biological processi

    1. tetracyclic triterpenoid biosynthetic process Source: TAIR

    Keywords - Molecular functioni

    Isomerase

    Enzyme and pathway databases

    BioCyciMetaCyc:AT4G15370-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Baruol synthase (EC:5.4.99.57)
    Short name:
    AtBARS1
    Alternative name(s):
    Pentacyclic triterpene synthase 2
    Short name:
    AtPEN2
    Gene namesi
    Name:BARS1
    Synonyms:PEN2
    Ordered Locus Names:At4g15370
    ORF Names:dl3730c, FCAALL.279
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G15370.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 759759Baruol synthasePRO_0000366137Add
    BLAST

    Proteomic databases

    PaxDbiO23390.
    PRIDEiO23390.

    Expressioni

    Gene expression databases

    GenevestigatoriO23390.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT4G15370.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO23390.
    SMRiO23390. Positions 593-633.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 19042PFTB 1Add
    BLAST
    Repeati522 – 56443PFTB 2Add
    BLAST
    Repeati641 – 68242PFTB 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the terpene cyclase/mutase family.Curated
    Contains 3 PFTB repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1657.
    HOGENOMiHOG000234317.
    KOiK16206.
    OMAiIFTHEHR.
    PhylomeDBiO23390.

    Family and domain databases

    Gene3Di1.50.10.20. 2 hits.
    InterProiIPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view]
    PfamiPF00432. Prenyltrans. 1 hit.
    [Graphical view]
    SUPFAMiSSF48239. SSF48239. 2 hits.
    TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
    PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    O23390-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWRLRIGAKA KDNTHLFTTN NYVGRQIWEF DANAGSPEEL AEVEEARRNF    50
    SNNRSRFKAS ADLLWRMQFL REKKFEQKIP RVIVEDAEKI TYEDAKTALR 100
    RGLLYFTALQ ADDGHWPAEN AGSIFFNAPF VICLYITGHL EKIFTHEHRV 150
    ELLRYMYNHQ NEDGGWGLHV ESPSNMFCSV INYICLRILG VEAGHDDKGS 200
    ACARARKWIL DHGGATYSPL IGKAWLSVLG VYDWSGCKPI PPEFWFLPSF 250
    FPVNGGTLWI YLRDIFMGLS YLYGKNFVAT STPLILQLRE EIYPEPYTNI 300
    SWRQARNRCA KEDLYYPQSF LQDLFWKGVH VFSENILNRW PFNNLIRQRA 350
    LRTTMELVHY HDEATRYITG GSVPKVIAVF HMLACWVEDP ESDYFKKHLA 400
    RVPDFIWIGE DGLKIQSFGS QVWDTALSLH VFIDGFDDDV DEEIRSTLLK 450
    GYDYLEKSQV TENPPGDYMK MFRHMAKGGW TFSDQDQGWP VSDCTAESLE 500
    CCLFFESMSS EFIGKKMDVE KLYDAVDFLL YLQSDNGGIT AWQPADGKLV 550
    EFIEDAVVEH EYVECTGSAI VALAQFNKQF PGYKKEEVER FITKGVKYIE 600
    DLQMVDGSWY GNWGVCFIYG TFFAVRGLVA AGKCYNNCEA IRRAVRFILD 650
    TQNTEGGWGE SYLSCPRKKY IPLIGNKTNV VNTGQALMVL IMGNQMKRDP 700
    LPVHRAAKVL INSQMDNGDF PQQEIMGVFK MNVMLHFPTY RNMFTLWALT 750
    HYTKALRGL 759
    Length:759
    Mass (Da):87,455
    Last modified:March 3, 2009 - v2
    Checksum:i620E96D9085213C1
    GO

    Sequence cautioni

    The sequence CAB10316.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAB78579.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97338 Genomic DNA. Translation: CAB10316.1. Sequence problems.
    AL161541 Genomic DNA. Translation: CAB78579.1. Sequence problems.
    CP002687 Genomic DNA. Translation: AEE83589.1.
    PIRiB71418.
    RefSeqiNP_193272.1. NM_117625.1.
    UniGeneiAt.54340.

    Genome annotation databases

    EnsemblPlantsiAT4G15370.1; AT4G15370.1; AT4G15370.
    GeneIDi827203.
    KEGGiath:AT4G15370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z97338 Genomic DNA. Translation: CAB10316.1 . Sequence problems.
    AL161541 Genomic DNA. Translation: CAB78579.1 . Sequence problems.
    CP002687 Genomic DNA. Translation: AEE83589.1 .
    PIRi B71418.
    RefSeqi NP_193272.1. NM_117625.1.
    UniGenei At.54340.

    3D structure databases

    ProteinModelPortali O23390.
    SMRi O23390. Positions 593-633.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT4G15370.1-P.

    Proteomic databases

    PaxDbi O23390.
    PRIDEi O23390.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G15370.1 ; AT4G15370.1 ; AT4G15370 .
    GeneIDi 827203.
    KEGGi ath:AT4G15370.

    Organism-specific databases

    TAIRi AT4G15370.

    Phylogenomic databases

    eggNOGi COG1657.
    HOGENOMi HOG000234317.
    KOi K16206.
    OMAi IFTHEHR.
    PhylomeDBi O23390.

    Enzyme and pathway databases

    BioCyci MetaCyc:AT4G15370-MONOMER.

    Gene expression databases

    Genevestigatori O23390.

    Family and domain databases

    Gene3Di 1.50.10.20. 2 hits.
    InterProi IPR001330. Prenyltrans.
    IPR018333. Squalene_cyclase.
    IPR002365. Terpene_synthase_CS.
    IPR008930. Terpenoid_cyclase/PrenylTrfase.
    [Graphical view ]
    Pfami PF00432. Prenyltrans. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48239. SSF48239. 2 hits.
    TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
    PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana."
      Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.
      , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.
      Nature 391:485-488(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana."
      Husselstein-Muller T., Schaller H., Benveniste P.
      Plant Mol. Biol. 45:75-92(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.
    5. "An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis."
      Lodeiro S., Xiong Q., Wilson W.K., Kolesnikova M.D., Onak C.S., Matsuda S.P.T.
      J. Am. Chem. Soc. 129:11213-11222(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY.

    Entry informationi

    Entry nameiBARS1_ARATH
    AccessioniPrimary (citable) accession number: O23390
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3