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O23390

- BARS1_ARATH

UniProt

O23390 - BARS1_ARATH

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Protein

Baruol synthase

Gene
BARS1, PEN2, At4g15370, dl3730c, FCAALL.279
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Converts oxidosqualene to baruol (90%) and 22 minor products.1 Publication

Catalytic activityi

(3S)-2,3-epoxy-2,3-dihydrosqualene = baruol.1 Publication

GO - Molecular functioni

  1. baruol synthase activity Source: TAIR

GO - Biological processi

  1. tetracyclic triterpenoid biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Enzyme and pathway databases

BioCyciMetaCyc:AT4G15370-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Baruol synthase (EC:5.4.99.57)
Short name:
AtBARS1
Alternative name(s):
Pentacyclic triterpene synthase 2
Short name:
AtPEN2
Gene namesi
Name:BARS1
Synonyms:PEN2
Ordered Locus Names:At4g15370
ORF Names:dl3730c, FCAALL.279
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G15370.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 759759Baruol synthasePRO_0000366137Add
BLAST

Proteomic databases

PaxDbiO23390.
PRIDEiO23390.

Expressioni

Gene expression databases

GenevestigatoriO23390.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G15370.1-P.

Structurei

3D structure databases

ProteinModelPortaliO23390.
SMRiO23390. Positions 593-633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati149 – 19042PFTB 1Add
BLAST
Repeati522 – 56443PFTB 2Add
BLAST
Repeati641 – 68242PFTB 3Add
BLAST

Sequence similaritiesi

Contains 3 PFTB repeats.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG1657.
HOGENOMiHOG000234317.
KOiK16206.
OMAiIFTHEHR.
PhylomeDBiO23390.

Family and domain databases

Gene3Di1.50.10.20. 2 hits.
InterProiIPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view]
PfamiPF00432. Prenyltrans. 1 hit.
[Graphical view]
SUPFAMiSSF48239. SSF48239. 2 hits.
TIGRFAMsiTIGR01787. squalene_cyclas. 1 hit.
PROSITEiPS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O23390-1 [UniParc]FASTAAdd to Basket

« Hide

MWRLRIGAKA KDNTHLFTTN NYVGRQIWEF DANAGSPEEL AEVEEARRNF    50
SNNRSRFKAS ADLLWRMQFL REKKFEQKIP RVIVEDAEKI TYEDAKTALR 100
RGLLYFTALQ ADDGHWPAEN AGSIFFNAPF VICLYITGHL EKIFTHEHRV 150
ELLRYMYNHQ NEDGGWGLHV ESPSNMFCSV INYICLRILG VEAGHDDKGS 200
ACARARKWIL DHGGATYSPL IGKAWLSVLG VYDWSGCKPI PPEFWFLPSF 250
FPVNGGTLWI YLRDIFMGLS YLYGKNFVAT STPLILQLRE EIYPEPYTNI 300
SWRQARNRCA KEDLYYPQSF LQDLFWKGVH VFSENILNRW PFNNLIRQRA 350
LRTTMELVHY HDEATRYITG GSVPKVIAVF HMLACWVEDP ESDYFKKHLA 400
RVPDFIWIGE DGLKIQSFGS QVWDTALSLH VFIDGFDDDV DEEIRSTLLK 450
GYDYLEKSQV TENPPGDYMK MFRHMAKGGW TFSDQDQGWP VSDCTAESLE 500
CCLFFESMSS EFIGKKMDVE KLYDAVDFLL YLQSDNGGIT AWQPADGKLV 550
EFIEDAVVEH EYVECTGSAI VALAQFNKQF PGYKKEEVER FITKGVKYIE 600
DLQMVDGSWY GNWGVCFIYG TFFAVRGLVA AGKCYNNCEA IRRAVRFILD 650
TQNTEGGWGE SYLSCPRKKY IPLIGNKTNV VNTGQALMVL IMGNQMKRDP 700
LPVHRAAKVL INSQMDNGDF PQQEIMGVFK MNVMLHFPTY RNMFTLWALT 750
HYTKALRGL 759
Length:759
Mass (Da):87,455
Last modified:March 3, 2009 - v2
Checksum:i620E96D9085213C1
GO

Sequence cautioni

The sequence CAB10316.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAB78579.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97338 Genomic DNA. Translation: CAB10316.1. Sequence problems.
AL161541 Genomic DNA. Translation: CAB78579.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83589.1.
PIRiB71418.
RefSeqiNP_193272.1. NM_117625.1.
UniGeneiAt.54340.

Genome annotation databases

EnsemblPlantsiAT4G15370.1; AT4G15370.1; AT4G15370.
GeneIDi827203.
KEGGiath:AT4G15370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z97338 Genomic DNA. Translation: CAB10316.1 . Sequence problems.
AL161541 Genomic DNA. Translation: CAB78579.1 . Sequence problems.
CP002687 Genomic DNA. Translation: AEE83589.1 .
PIRi B71418.
RefSeqi NP_193272.1. NM_117625.1.
UniGenei At.54340.

3D structure databases

ProteinModelPortali O23390.
SMRi O23390. Positions 593-633.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT4G15370.1-P.

Proteomic databases

PaxDbi O23390.
PRIDEi O23390.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT4G15370.1 ; AT4G15370.1 ; AT4G15370 .
GeneIDi 827203.
KEGGi ath:AT4G15370.

Organism-specific databases

TAIRi AT4G15370.

Phylogenomic databases

eggNOGi COG1657.
HOGENOMi HOG000234317.
KOi K16206.
OMAi IFTHEHR.
PhylomeDBi O23390.

Enzyme and pathway databases

BioCyci MetaCyc:AT4G15370-MONOMER.

Gene expression databases

Genevestigatori O23390.

Family and domain databases

Gene3Di 1.50.10.20. 2 hits.
InterProi IPR001330. Prenyltrans.
IPR018333. Squalene_cyclase.
IPR002365. Terpene_synthase_CS.
IPR008930. Terpenoid_cyclase/PrenylTrfase.
[Graphical view ]
Pfami PF00432. Prenyltrans. 1 hit.
[Graphical view ]
SUPFAMi SSF48239. SSF48239. 2 hits.
TIGRFAMsi TIGR01787. squalene_cyclas. 1 hit.
PROSITEi PS01074. TERPENE_SYNTHASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana."
    Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.
    , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.
    Nature 391:485-488(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana."
    Husselstein-Muller T., Schaller H., Benveniste P.
    Plant Mol. Biol. 45:75-92(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, NOMENCLATURE.
  5. "An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis."
    Lodeiro S., Xiong Q., Wilson W.K., Kolesnikova M.D., Onak C.S., Matsuda S.P.T.
    J. Am. Chem. Soc. 129:11213-11222(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY.

Entry informationi

Entry nameiBARS1_ARATH
AccessioniPrimary (citable) accession number: O23390
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: June 11, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi