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Protein

Histone-lysine N-methyltransferase ATXR3

Gene

ATXR3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed:21037105, PubMed:20937886).

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].1 Publication

GO - Molecular functioni

  • histone methyltransferase activity (H3-K4 specific) Source: TAIR

GO - Biological processi

  • carpel development Source: TAIR
  • post-embryonic development Source: TAIR
  • stamen development Source: TAIR
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase ATXR3Curated (EC:2.1.1.431 Publication)
Alternative name(s):
Protein SET DOMAIN GROUP 2
Trithorax-related protein 3
Short name:
TRX-related protein 3
Gene namesi
Name:ATXR3
Synonyms:SDG2, SET2
Ordered Locus Names:At4g15180
ORF Names:dl3635w, FCAALL.214
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G15180.
TAIRilocus:2129755. AT4G15180.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Pleiotropic effects on plant growth and development, including dwarf size, aberrant root development and sterile flowers.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333601 – 2335Histone-lysine N-methyltransferase ATXR3Add BLAST2335

Proteomic databases

PaxDbiO23372.
PRIDEiO23372.

PTM databases

iPTMnetiO23372.

Expressioni

Tissue specificityi

Expressed in roots, leaves, stems and inflorescences.1 Publication

Gene expression databases

GenevisibleiO23372. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G15180.1.

Structurei

3D structure databases

ProteinModelPortaliO23372.
SMRiO23372.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1765 – 1904SETPROSITE-ProRule annotationAdd BLAST140

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi435 – 529Arg-richAdd BLAST95
Compositional biasi1535 – 1573Ser-richAdd BLAST39

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1080. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000034228.
InParanoidiO23372.
OMAiISYVHIQ.
OrthoDBiEOG0936008R.
PhylomeDBiO23372.

Family and domain databases

Gene3Di3.30.1490.40. 2 hits.
InterProiView protein in InterPro
IPR035445. GYF-like_dom_sf.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
SUPFAMiSSF55277. SSF55277. 1 hit.
PROSITEiView protein in PROSITE
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

O23372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGGVACMP LLNIMEKLPI VEKTTLCGGN ESKTAATTEN GHTSIATKVP
60 70 80 90 100
ESQPANKPSA SSQPVKKKRI VKVIRKVVKR RPKQPQKQAD EQLKDQPPSQ
110 120 130 140 150
VVQLPAESQL QIKEQDKKSE FKGGTSGVKE VENGGDSGFK DEVEEGELGT
160 170 180 190 200
LKLHEDLENG EISPVKSLQK SEIEKGEIVG ESWKKDEPTK GEFSHLKYHK
210 220 230 240 250
GYVERRDFSA DKNWKGGKEE REFRSWRDPS DEIEKGEFIP DRWQKMDTGK
260 270 280 290 300
DDHSYIRSRR NGVDREKTWK YEYEYERTPP GGRFVNEDIY HQREFRSGLD
310 320 330 340 350
RTTRISSKIV IEENLHKNEY NNSSNFVKEY SSTGNRLKRH GAEPDSIERK
360 370 380 390 400
HSYADYGDYG SSKCRKLSDD CSRSLHSDHY SQHSAERLYR DSYPSKNSSL
410 420 430 440 450
EKYPRKHQDA SFPAKAFSDK HGHSPSRSDW SPHDRSRYHE NRDRSPYARE
460 470 480 490 500
RSPYIFEKSS HARKRSPRDR RHHDYRRSPS YSEWSPHDRS RPSDRRDYIP
510 520 530 540 550
NFMEDTQSDR NRRNGHREIS RKSGVRERRD CQTGTELEIK HKYKESNGKE
560 570 580 590 600
STSSSKELQG KNILYNNSLL VEKNSVCDSS KIPVPCATGK EPVQVGEAPT
610 620 630 640 650
EELPSMEVDM DICDTPPHEP MASDSSLGKW FYLDYYGTEH GPARLSDLKA
660 670 680 690 700
LMEQGILFSD HMIKHSDNNR WLVNPPEAPG NLLEDIADTT EAVCIEQGAG
710 720 730 740 750
DSLPELVSVR TLPDGKEIFV ENREDFQIDM RVENLLDGRT ITPGREFETL
760 770 780 790 800
GEALKVNVEF EETRRCVTSE GVVGMFRPMK RAIEEFKSDD AYGSESDEIG
810 820 830 840 850
SWFSGRWSCK GGDWIRQDEA SQDRYYKKKI VLNDGFPLCL MQKSGHEDPR
860 870 880 890 900
WHHKDDLYYP LSSSRLELPL WAFSVVDERN QTRGVKASLL SVVRLNSLVV
910 920 930 940 950
NDQVPPIPDP RAKVRSKERC PSRPARPSPA SSDSKRESVE SHSQSTASTG
960 970 980 990 1000
QDSQGLWKTD TSVNTPRDRL CTVDDLQLHI GDWFYTDGAG QEQGPLSFSE
1010 1020 1030 1040 1050
LQKLVEKGFI KSHSSVFRKS DKIWVPVTSI TKSPETIAML RGKTPALPSA
1060 1070 1080 1090 1100
CQGLVVSETQ DFKYSEMDTS LNSFHGVHPQ FLGYFRGKLH QLVMKTFKSR
1110 1120 1130 1140 1150
DFSAAINDVV DSWIHARQPK KESEKYMYQS SELNSCYTKR ARLMAGESGE
1160 1170 1180 1190 1200
DSEMEDTQMF QKDELTFEDL CGDLTFNIEG NRSAGTVGIY WGLLDGHALA
1210 1220 1230 1240 1250
RVFHMLRYDV KSLAFASMTC RHWKATINSY KDISRQVDLS SLGPSCTDSR
1260 1270 1280 1290 1300
LRSIMNTYNK EKIDSIILVG CTNVTASMLE EILRLHPRIS SVDITGCSQF
1310 1320 1330 1340 1350
GDLTVNYKNV SWLRCQNTRS GELHSRIRSL KQTTDVAKSK GLGGDTDDFG
1360 1370 1380 1390 1400
NLKDYFDRVE KRDSANQLFR RSLYKRSKLY DARRSSAILS RDARIRRWAI
1410 1420 1430 1440 1450
KKSEHGYKRV EEFLASSLRG IMKQNTFDFF ALKVSQIEEK MKNGYYVSHG
1460 1470 1480 1490 1500
LRSVKEDISR MCREAIKDEL MKSWQDGSGL SSATKYNKKL SKTVAEKKYM
1510 1520 1530 1540 1550
SRTSDTFGVN GASDYGEYAS DREIKRRLSK LNRKSFSSES DTSSELSDNG
1560 1570 1580 1590 1600
KSDNYSSASA SESESDIRSE GRSQDLRIEK YFTADDSFDS VTEEREWGAR
1610 1620 1630 1640 1650
MTKASLVPPV TRKYEVIEKY AIVADEEEVQ RKMRVSLPED YGEKLNAQRN
1660 1670 1680 1690 1700
GIEELDMELP EVKEYKPRKL LGDEVLEQEV YGIDPYTHNL LLDSMPGELD
1710 1720 1730 1740 1750
WSLQDKHSFI EDVVLRTLNR QVRLFTGSGS TPMVFPLRPV IEELKESARE
1760 1770 1780 1790 1800
ECDIRTMKMC QGVLKEIESR SDDKYVSYRK GLGVVCNKEG GFGEEDFVVE
1810 1820 1830 1840 1850
FLGEVYPVWK WFEKQDGIRS LQENKTDPAP EFYNIYLERP KGDADGYDLV
1860 1870 1880 1890 1900
VVDAMHMANY ASRICHSCRP NCEAKVTAVD GHYQIGIYSV RAIEYGEEIT
1910 1920 1930 1940 1950
FDYNSVTESK EEYEASVCLC GSQVCRGSYL NLTGEGAFQK VLKDWHGLLE
1960 1970 1980 1990 2000
RHRLMLEACV LNSVSEEDYL ELGRAGLGSC LLGGLPDWMI AYSARLVRFI
2010 2020 2030 2040 2050
NFERTKLPEE ILKHNLEEKR KYFSDIHLDV EKSDAEVQAE GVYNQRLQNL
2060 2070 2080 2090 2100
AVTLDKVRYV MRHVFGDPKN APPPLERLTP EETVSFVWNG DGSLVDELLQ
2110 2120 2130 2140 2150
SLSPHLEEGP LNELRSKIHG HDPSGSADVL KELQRSLLWL RDEIRDLPCT
2160 2170 2180 2190 2200
YKCRNDAAAD LIHIYAYTKC FFKVREYQSF ISSPVHISPL DLGAKYADKL
2210 2220 2230 2240 2250
GESIKEYRKT YGENYCLGQL IYWYNQTNTD PDLTLVKATR GCLSLPDVAS
2260 2270 2280 2290 2300
FYAKAQKPSK HRVYGPKTVK TMVSQMSKQP QRPWPKDKIW TFKSTPRVFG
2310 2320 2330
SPMFDAVLNN SSSLDRELLQ WLRNRRHVFQ ATWDS
Length:2,335
Mass (Da):267,060
Last modified:March 24, 2009 - v2
Checksum:i26BA2C3AF6B346EA
GO

Sequence cautioni

The sequence CAB10297 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78560 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97338 Genomic DNA. Translation: CAB10297.1. Sequence problems.
AL161540 Genomic DNA. Translation: CAB78560.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83565.1.
AK226725 mRNA. Translation: BAE98829.1.
PIRiG71415.
RefSeqiNP_193253.4. NM_117606.5.
UniGeneiAt.21894.
At.263.

Genome annotation databases

EnsemblPlantsiAT4G15180.1; AT4G15180.1; AT4G15180.
GeneIDi827183.
GrameneiAT4G15180.1; AT4G15180.1; AT4G15180.
KEGGiath:AT4G15180.

Similar proteinsi

Entry informationi

Entry nameiATXR3_ARATH
AccessioniPrimary (citable) accession number: O23372
Secondary accession number(s): Q0WVL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 24, 2009
Last modified: November 22, 2017
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families