Reviewed, UniProtKB/Swiss-Prot O23372 (ATXR3_ARATH)

Names and origin

Protein names

Recommended name:
    Probable histone-lysine N-methyltransferase ATXR3
    EC=2.1.1.43
Alternative name(s):
    Trithorax-related protein 3
      Short name=TRX-related protein 3
    Protein SET DOMAIN GROUP 2

Gene names

Name:	ATXR3
Synonyms:	SDG2, SET2
Ordered Locus Names:	At4g15180
ORF Names:	dl3635w, FCAALL.214

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	2335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histone methyltransferase By similarity.
Catalytic activity	S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the histone-lysine methyltransferase family. TRX/MLL subfamily. Contains 1 SET domain.
Sequence caution	The sequence CAB10297.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAB78560.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2335	2335	Probable histone-lysine N-methyltransferase ATXR3		PRO_0000233360
Regions
	Domain	1771 – 1908	138	SET
	Compositional bias	435 – 529	95	Arg-rich
	Compositional bias	1535 – 1573	39	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	O23372-1 [UniParc]. Last modified March 24, 2009. Version 2. Checksum: 26BA2C3AF6B346EA	FASTA	2,335	267,060
	10 20 30 40 50 60 MSDGGVACMP LLNIMEKLPI VEKTTLCGGN ESKTAATTEN GHTSIATKVP ESQPANKPSA 70 80 90 100 110 120 SSQPVKKKRI VKVIRKVVKR RPKQPQKQAD EQLKDQPPSQ VVQLPAESQL QIKEQDKKSE 130 140 150 160 170 180 FKGGTSGVKE VENGGDSGFK DEVEEGELGT LKLHEDLENG EISPVKSLQK SEIEKGEIVG 190 200 210 220 230 240 ESWKKDEPTK GEFSHLKYHK GYVERRDFSA DKNWKGGKEE REFRSWRDPS DEIEKGEFIP 250 260 270 280 290 300 DRWQKMDTGK DDHSYIRSRR NGVDREKTWK YEYEYERTPP GGRFVNEDIY HQREFRSGLD 310 320 330 340 350 360 RTTRISSKIV IEENLHKNEY NNSSNFVKEY SSTGNRLKRH GAEPDSIERK HSYADYGDYG 370 380 390 400 410 420 SSKCRKLSDD CSRSLHSDHY SQHSAERLYR DSYPSKNSSL EKYPRKHQDA SFPAKAFSDK 430 440 450 460 470 480 HGHSPSRSDW SPHDRSRYHE NRDRSPYARE RSPYIFEKSS HARKRSPRDR RHHDYRRSPS 490 500 510 520 530 540 YSEWSPHDRS RPSDRRDYIP NFMEDTQSDR NRRNGHREIS RKSGVRERRD CQTGTELEIK 550 560 570 580 590 600 HKYKESNGKE STSSSKELQG KNILYNNSLL VEKNSVCDSS KIPVPCATGK EPVQVGEAPT 610 620 630 640 650 660 EELPSMEVDM DICDTPPHEP MASDSSLGKW FYLDYYGTEH GPARLSDLKA LMEQGILFSD 670 680 690 700 710 720 HMIKHSDNNR WLVNPPEAPG NLLEDIADTT EAVCIEQGAG DSLPELVSVR TLPDGKEIFV 730 740 750 760 770 780 ENREDFQIDM RVENLLDGRT ITPGREFETL GEALKVNVEF EETRRCVTSE GVVGMFRPMK 790 800 810 820 830 840 RAIEEFKSDD AYGSESDEIG SWFSGRWSCK GGDWIRQDEA SQDRYYKKKI VLNDGFPLCL 850 860 870 880 890 900 MQKSGHEDPR WHHKDDLYYP LSSSRLELPL WAFSVVDERN QTRGVKASLL SVVRLNSLVV 910 920 930 940 950 960 NDQVPPIPDP RAKVRSKERC PSRPARPSPA SSDSKRESVE SHSQSTASTG QDSQGLWKTD 970 980 990 1000 1010 1020 TSVNTPRDRL CTVDDLQLHI GDWFYTDGAG QEQGPLSFSE LQKLVEKGFI KSHSSVFRKS 1030 1040 1050 1060 1070 1080 DKIWVPVTSI TKSPETIAML RGKTPALPSA CQGLVVSETQ DFKYSEMDTS LNSFHGVHPQ 1090 1100 1110 1120 1130 1140 FLGYFRGKLH QLVMKTFKSR DFSAAINDVV DSWIHARQPK KESEKYMYQS SELNSCYTKR 1150 1160 1170 1180 1190 1200 ARLMAGESGE DSEMEDTQMF QKDELTFEDL CGDLTFNIEG NRSAGTVGIY WGLLDGHALA 1210 1220 1230 1240 1250 1260 RVFHMLRYDV KSLAFASMTC RHWKATINSY KDISRQVDLS SLGPSCTDSR LRSIMNTYNK 1270 1280 1290 1300 1310 1320 EKIDSIILVG CTNVTASMLE EILRLHPRIS SVDITGCSQF GDLTVNYKNV SWLRCQNTRS 1330 1340 1350 1360 1370 1380 GELHSRIRSL KQTTDVAKSK GLGGDTDDFG NLKDYFDRVE KRDSANQLFR RSLYKRSKLY 1390 1400 1410 1420 1430 1440 DARRSSAILS RDARIRRWAI KKSEHGYKRV EEFLASSLRG IMKQNTFDFF ALKVSQIEEK 1450 1460 1470 1480 1490 1500 MKNGYYVSHG LRSVKEDISR MCREAIKDEL MKSWQDGSGL SSATKYNKKL SKTVAEKKYM 1510 1520 1530 1540 1550 1560 SRTSDTFGVN GASDYGEYAS DREIKRRLSK LNRKSFSSES DTSSELSDNG KSDNYSSASA 1570 1580 1590 1600 1610 1620 SESESDIRSE GRSQDLRIEK YFTADDSFDS VTEEREWGAR MTKASLVPPV TRKYEVIEKY 1630 1640 1650 1660 1670 1680 AIVADEEEVQ RKMRVSLPED YGEKLNAQRN GIEELDMELP EVKEYKPRKL LGDEVLEQEV 1690 1700 1710 1720 1730 1740 YGIDPYTHNL LLDSMPGELD WSLQDKHSFI EDVVLRTLNR QVRLFTGSGS TPMVFPLRPV 1750 1760 1770 1780 1790 1800 IEELKESARE ECDIRTMKMC QGVLKEIESR SDDKYVSYRK GLGVVCNKEG GFGEEDFVVE 1810 1820 1830 1840 1850 1860 FLGEVYPVWK WFEKQDGIRS LQENKTDPAP EFYNIYLERP KGDADGYDLV VVDAMHMANY 1870 1880 1890 1900 1910 1920 ASRICHSCRP NCEAKVTAVD GHYQIGIYSV RAIEYGEEIT FDYNSVTESK EEYEASVCLC 1930 1940 1950 1960 1970 1980 GSQVCRGSYL NLTGEGAFQK VLKDWHGLLE RHRLMLEACV LNSVSEEDYL ELGRAGLGSC 1990 2000 2010 2020 2030 2040 LLGGLPDWMI AYSARLVRFI NFERTKLPEE ILKHNLEEKR KYFSDIHLDV EKSDAEVQAE 2050 2060 2070 2080 2090 2100 GVYNQRLQNL AVTLDKVRYV MRHVFGDPKN APPPLERLTP EETVSFVWNG DGSLVDELLQ 2110 2120 2130 2140 2150 2160 SLSPHLEEGP LNELRSKIHG HDPSGSADVL KELQRSLLWL RDEIRDLPCT YKCRNDAAAD 2170 2180 2190 2200 2210 2220 LIHIYAYTKC FFKVREYQSF ISSPVHISPL DLGAKYADKL GESIKEYRKT YGENYCLGQL 2230 2240 2250 2260 2270 2280 IYWYNQTNTD PDLTLVKATR GCLSLPDVAS FYAKAQKPSK HRVYGPKTVK TMVSQMSKQP 2290 2300 2310 2320 2330 QRPWPKDKIW TFKSTPRVFG SPMFDAVLNN SSSLDRELLQ WLRNRRHVFQ ATWDS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis thaliana." Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E. , Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N. Nature 391:485-488(1998) [PubMed: 9461215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs." Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K. , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K. Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-517. Strain: cv. Columbia.
[4]	"The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes." Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B. Nucleic Acids Res. 29:4319-4333(2001) [PubMed: 11691919] [Abstract] Cited for: NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z97338 Genomic DNA. Translation: CAB10297.1. Sequence problems. AL161540 Genomic DNA. Translation: CAB78560.1. Sequence problems. AK226725 mRNA. Translation: BAE98829.1.
IPI	IPI00523932.
PIR	G71415.
RefSeq	NP_193253.4.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	O23372.
ProMEX	O23372.
Genome annotation databases
GeneID	827183.
GenomeReviews	Gene locus AT4G15180 in contig CT486007_GR.
Organism-specific databases
TAIR	At4g15180.
Enzyme and pathway databases
BRENDA	2.1.1.43. 302.
Gene expression databases
ArrayExpress	O23372.
Genevestigator	O23372.
GermOnline	AT4G15180. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001214. SET. [Graphical view]
Pfam	PF00856. SET. 1 hit. [Graphical view]
SMART	SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATXR3_ARATH

Accession

Primary (citable) accession number: O23372
Secondary accession number(s): Q0WVL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	March 24, 2009
Last modified:	October 13, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)