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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Associates with cyclin-dependent kinases (CDKs) and plays an essential role in the regulation of the cell cycle that affects plant growth rate. May inhibit both the G1/S and G2/M phases.1 Publication

Miscellaneous

Plants overexpressing CKS1 show reduced leaf size and root growth rates resulting from an increase of the cell-cycle duration with an equal extension of both G1 and G2 phases and a shortening of the meristem.

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA endoreduplication Source: TAIR
  • mitotic cell cycle Source: TAIR
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of cell cycle Source: TAIR
  • regulation of mitotic cell cycle Source: GO_Central

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Alternative name(s):
CKS1-At
Gene namesi
Name:CKS1
Ordered Locus Names:At2g27960
ORF Names:T1E2.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G27960
TAIRilocus:2057836 AT2G27960

Subcellular locationi

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61E → Q: Loss of function and impaired interaction with CDKA-1 or CDKB1-1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002940941 – 87Cyclin-dependent kinases regulatory subunit 1Add BLAST87

Proteomic databases

PaxDbiO23249

Expressioni

Gene expression databases

ExpressionAtlasiO23249 baseline and differential
GenevisibleiO23249 AT

Interactioni

Subunit structurei

Interacts with CDKA-1 (PubMed:10100639, PubMed:11319029, PubMed:9276444, PubMed:20706207). Interacts with CDKB1-1, CDKB1-2 and CDKB2-1 (PubMed:11319029, PubMed:9276444, PubMed:11432958). Interacts with CYCD2-1 and At4g14310 (PubMed:20706207).5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2690, 51 interactors
IntActiO23249, 40 interactors
STRINGi3702.AT2G27960.1

Structurei

3D structure databases

ProteinModelPortaliO23249
SMRiO23249
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484 Eukaryota
ENOG4111UAN LUCA
HOGENOMiHOG000157009
InParanoidiO23249
KOiK02219
OMAiIHYSSRY
OrthoDBiEOG09360WQ4
PhylomeDBiO23249

Family and domain databases

Gene3Di3.30.170.10, 1 hit
InterProiView protein in InterPro
IPR000789 Cyclin-dep_kinase_reg-sub
IPR036858 Cyclin-dep_kinase_reg-sub_sf
PfamiView protein in Pfam
PF01111 CKS, 1 hit
PRINTSiPR00296 CYCLINKINASE
SMARTiView protein in SMART
SM01084 CKS, 1 hit
SUPFAMiSSF55637 SSF55637, 1 hit
PROSITEiView protein in PROSITE
PS00944 CKS_1, 1 hit

Sequencei

Sequence statusi: Complete.

O23249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQIQYSEKY FDDTFEYRHV VLPPEVAKLL PKNRLLSENE WRAIGVQQSR
60 70 80
GWVHYAVHRP EPHIMLFRRP LNYQQQQENQ AQNMLVK
Length:87
Mass (Da):10,521
Last modified:January 1, 1998 - v1
Checksum:iC8C58DEBDD7A095D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000016 mRNA Translation: CAA03859.1
AC006929 Genomic DNA Translation: AAD21506.1
CP002685 Genomic DNA Translation: AEC08064.1
AK175719 mRNA Translation: BAD43482.1
AK175828 mRNA Translation: BAD43591.1
AK176119 mRNA Translation: BAD43882.1
BT024528 mRNA Translation: ABD38867.1
AY088339 mRNA Translation: AAM65878.1
PIRiA84679
RefSeqiNP_180363.1, NM_128355.3
UniGeneiAt.14

Genome annotation databases

EnsemblPlantsiAT2G27960.1; AT2G27960.1; AT2G27960
GeneIDi817340
GrameneiAT2G27960.1; AT2G27960.1; AT2G27960
KEGGiath:AT2G27960

Similar proteinsi

Entry informationi

Entry nameiCKS1_ARATH
AccessioniPrimary (citable) accession number: O23249
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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