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Protein

Cyclin-dependent kinases regulatory subunit 1

Gene

CKS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with cyclin-dependent kinases (CDKs) and plays an essential role in the regulation of the cell cycle that affects plant growth rate. May inhibit both the G1/S and G2/M phases.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • DNA endoreduplication Source: TAIR
  • mitotic cell cycle Source: TAIR
  • positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
  • positive regulation of transcription, DNA-templated Source: GO_Central
  • regulation of cell cycle Source: TAIR
  • regulation of mitotic cell cycle Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinases regulatory subunit 1
Alternative name(s):
CKS1-At
Gene namesi
Name:CKS1
Ordered Locus Names:At2g27960
ORF Names:T1E2.12
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G27960.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi61E → Q: Loss of function and impaired interaction with CDKA-1 or CDKB1-1. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002940941 – 87Cyclin-dependent kinases regulatory subunit 1Add BLAST87

Proteomic databases

PaxDbiO23249.

Expressioni

Gene expression databases

GenevisibleiO23249. AT.

Interactioni

Subunit structurei

Interacts with CDKA-1 (PubMed:10100639, PubMed:11319029, PubMed:9276444, PubMed:20706207). Interacts with CDKB1-1, CDKB1-2 and CDKB2-1 (PubMed:11319029, PubMed:9276444, PubMed:11432958). Interacts with CYCD2-1 and At4g14310 (PubMed:20706207).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CDKA-1P241009EBI-1253127,EBI-371713
CDKB1-1P258597EBI-1253127,EBI-1253311
CDKB2-1Q8LF805EBI-1253127,EBI-1253579

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2690. 51 interactors.
IntActiO23249. 41 interactors.
STRINGi3702.AT2G27960.1.

Structurei

3D structure databases

ProteinModelPortaliO23249.
SMRiO23249.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CKS family.Curated

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
HOGENOMiHOG000157009.
InParanoidiO23249.
KOiK02219.
OMAiQDMIHYS.
OrthoDBiEOG09360WQ4.
PhylomeDBiO23249.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O23249-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQIQYSEKY FDDTFEYRHV VLPPEVAKLL PKNRLLSENE WRAIGVQQSR
60 70 80
GWVHYAVHRP EPHIMLFRRP LNYQQQQENQ AQNMLVK
Length:87
Mass (Da):10,521
Last modified:January 1, 1998 - v1
Checksum:iC8C58DEBDD7A095D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000016 mRNA. Translation: CAA03859.1.
AC006929 Genomic DNA. Translation: AAD21506.1.
CP002685 Genomic DNA. Translation: AEC08064.1.
AK175719 mRNA. Translation: BAD43482.1.
AK175828 mRNA. Translation: BAD43591.1.
AK176119 mRNA. Translation: BAD43882.1.
BT024528 mRNA. Translation: ABD38867.1.
AY088339 mRNA. Translation: AAM65878.1.
PIRiA84679.
RefSeqiNP_180363.1. NM_128355.3.
UniGeneiAt.14.

Genome annotation databases

EnsemblPlantsiAT2G27960.1; AT2G27960.1; AT2G27960.
GeneIDi817340.
GrameneiAT2G27960.1; AT2G27960.1; AT2G27960.
KEGGiath:AT2G27960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000016 mRNA. Translation: CAA03859.1.
AC006929 Genomic DNA. Translation: AAD21506.1.
CP002685 Genomic DNA. Translation: AEC08064.1.
AK175719 mRNA. Translation: BAD43482.1.
AK175828 mRNA. Translation: BAD43591.1.
AK176119 mRNA. Translation: BAD43882.1.
BT024528 mRNA. Translation: ABD38867.1.
AY088339 mRNA. Translation: AAM65878.1.
PIRiA84679.
RefSeqiNP_180363.1. NM_128355.3.
UniGeneiAt.14.

3D structure databases

ProteinModelPortaliO23249.
SMRiO23249.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2690. 51 interactors.
IntActiO23249. 41 interactors.
STRINGi3702.AT2G27960.1.

Proteomic databases

PaxDbiO23249.

Protocols and materials databases

DNASUi817340.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G27960.1; AT2G27960.1; AT2G27960.
GeneIDi817340.
GrameneiAT2G27960.1; AT2G27960.1; AT2G27960.
KEGGiath:AT2G27960.

Organism-specific databases

TAIRiAT2G27960.

Phylogenomic databases

eggNOGiKOG3484. Eukaryota.
ENOG4111UAN. LUCA.
HOGENOMiHOG000157009.
InParanoidiO23249.
KOiK02219.
OMAiQDMIHYS.
OrthoDBiEOG09360WQ4.
PhylomeDBiO23249.

Miscellaneous databases

PROiO23249.

Gene expression databases

GenevisibleiO23249. AT.

Family and domain databases

Gene3Di3.30.170.10. 1 hit.
InterProiIPR000789. Cyclin-dep_kinase_reg-sub.
[Graphical view]
PfamiPF01111. CKS. 1 hit.
[Graphical view]
PRINTSiPR00296. CYCLINKINASE.
SMARTiSM01084. CKS. 1 hit.
[Graphical view]
SUPFAMiSSF55637. SSF55637. 1 hit.
PROSITEiPS00944. CKS_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKS1_ARATH
AccessioniPrimary (citable) accession number: O23249
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants overexpressing CKS1 show reduced leaf size and root growth rates resulting from an increase of the cell-cycle duration with an equal extension of both G1 and G2 phases and a shortening of the meristem.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.