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Protein

Peroxidase 49

Gene

PER49

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei66 – 661Transition state stabilizerPROSITE-ProRule annotation
Active sitei70 – 701Proton acceptorPROSITE-ProRule annotation
Metal bindingi71 – 711Calcium 1PROSITE-ProRule annotation
Metal bindingi74 – 741Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi76 – 761Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi78 – 781Calcium 1PROSITE-ProRule annotation
Metal bindingi80 – 801Calcium 1PROSITE-ProRule annotation
Binding sitei167 – 1671Substrate; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi197 – 1971Iron (heme axial ligand)PROSITE-ProRule annotation
Metal bindingi198 – 1981Calcium 2PROSITE-ProRule annotation
Metal bindingi249 – 2491Calcium 2PROSITE-ProRule annotation
Metal bindingi252 – 2521Calcium 2PROSITE-ProRule annotation
Metal bindingi257 – 2571Calcium 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G36430-MONOMER.

Protein family/group databases

PeroxiBasei215. AtPrx49.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 49 (EC:1.11.1.7)
Short name:
Atperox P49
Alternative name(s):
ATP31
Gene namesi
Name:PER49
Synonyms:DIDI 6G-3B, P49
Ordered Locus Names:At4g36430
ORF Names:AP22.54, C7A10.930
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G36430.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

  • cell wall Source: TAIR
  • extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 331309Peroxidase 49PRO_0000023714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 119PROSITE-ProRule annotation
Disulfide bondi72 ↔ 77PROSITE-ProRule annotation
Disulfide bondi125 ↔ 326PROSITE-ProRule annotation
Glycosylationi170 – 1701N-linked (GlcNAc...)Sequence analysis
Disulfide bondi204 ↔ 236PROSITE-ProRule annotation
Glycosylationi213 – 2131N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO23237.
PRIDEiO23237.

PTM databases

SwissPalmiO23237.

Expressioni

Gene expression databases

GenevisibleiO23237. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G36430.1.

Structurei

3D structure databases

ProteinModelPortaliO23237.
SMRiO23237. Positions 29-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQM. Eukaryota.
ENOG410YA1B. LUCA.
HOGENOMiHOG000237557.
InParanoidiO23237.
KOiK00430.
OMAiGHTIGFF.
OrthoDBiEOG09360H0D.
PhylomeDBiO23237.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLTSFLLL LSLICFVPLC LCDKSYGGKL FPGYYAHSCP QVNEIVRSVV
60 70 80 90 100
AKAVARETRM AASLLRLHFH DCFVQGCDGS LLLDSSGRVA TEKNSNPNSK
110 120 130 140 150
SARGFDVVDQ IKAELEKQCP GTVSCADVLT LAARDSSVLT GGPSWVVPLG
160 170 180 190 200
RRDSRSASLS QSNNNIPAPN NTFQTILSKF NRQGLDITDL VALSGSHTIG
210 220 230 240 250
FSRCTSFRQR LYNQSGNGSP DMTLEQSFAA NLRQRCPKSG GDQILSVLDI
260 270 280 290 300
ISAASFDNSY FKNLIENKGL LNSDQVLFSS NEKSRELVKK YAEDQGEFFE
310 320 330
QFAESMIKMG NISPLTGSSG EIRKNCRKIN S
Length:331
Mass (Da):36,164
Last modified:May 1, 1999 - v2
Checksum:iE9C0130D77406624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ286345 mRNA. Translation: CAB71009.1.
AF452384 mRNA. Translation: AAL40848.1.
Z99708 Genomic DNA. Translation: CAB16848.1.
AL161589 Genomic DNA. Translation: CAB80309.1.
CP002687 Genomic DNA. Translation: AEE86655.1.
AY074296 mRNA. Translation: AAL66993.1.
AY117238 mRNA. Translation: AAM51313.1.
PIRiA85430.
RefSeqiNP_195361.1. NM_119806.2.
UniGeneiAt.4607.

Genome annotation databases

EnsemblPlantsiAT4G36430.1; AT4G36430.1; AT4G36430.
GeneIDi829795.
GrameneiAT4G36430.1; AT4G36430.1; AT4G36430.
KEGGiath:AT4G36430.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ286345 mRNA. Translation: CAB71009.1.
AF452384 mRNA. Translation: AAL40848.1.
Z99708 Genomic DNA. Translation: CAB16848.1.
AL161589 Genomic DNA. Translation: CAB80309.1.
CP002687 Genomic DNA. Translation: AEE86655.1.
AY074296 mRNA. Translation: AAL66993.1.
AY117238 mRNA. Translation: AAM51313.1.
PIRiA85430.
RefSeqiNP_195361.1. NM_119806.2.
UniGeneiAt.4607.

3D structure databases

ProteinModelPortaliO23237.
SMRiO23237. Positions 29-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G36430.1.

Protein family/group databases

PeroxiBasei215. AtPrx49.

PTM databases

SwissPalmiO23237.

Proteomic databases

PaxDbiO23237.
PRIDEiO23237.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36430.1; AT4G36430.1; AT4G36430.
GeneIDi829795.
GrameneiAT4G36430.1; AT4G36430.1; AT4G36430.
KEGGiath:AT4G36430.

Organism-specific databases

TAIRiAT4G36430.

Phylogenomic databases

eggNOGiENOG410IIQM. Eukaryota.
ENOG410YA1B. LUCA.
HOGENOMiHOG000237557.
InParanoidiO23237.
KOiK00430.
OMAiGHTIGFF.
OrthoDBiEOG09360H0D.
PhylomeDBiO23237.

Enzyme and pathway databases

BioCyciARA:AT4G36430-MONOMER.

Miscellaneous databases

PROiO23237.

Gene expression databases

GenevisibleiO23237. AT.

Family and domain databases

InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER49_ARATH
AccessioniPrimary (citable) accession number: O23237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1999
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.