ID CBSX1_ARATH Reviewed; 236 AA. AC O23193; DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 2. DT 24-JAN-2024, entry version 130. DE RecName: Full=CBS domain-containing protein CBSX1, chloroplastic; DE AltName: Full=CBS domain-containing protein 2; DE Short=AtCDCP2; DE AltName: Full=Protein LOSS OF THE TIMING OF ET AND JA BIOSYNTHESIS 2; DE Short=AtLEJ2; DE Flags: Precursor; GN Name=CBSX1; Synonyms=CDCP2; OrderedLocusNames=At4g36910; GN ORFNames=AP22.61, C7A10.450; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=9461215; DOI=10.1038/35140; RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C., RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P., RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E., RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R., RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M., RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M., RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A., RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D., RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A., RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S., RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G., RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.; RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis RT thaliana."; RL Nature 391:485-488(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617198; DOI=10.1038/47134; RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M., RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., RA Martienssen R., McCombie W.R.; RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."; RL Nature 402:769-777(1999). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., RA Feldmann K.A.; RT "Full-length cDNA from Arabidopsis thaliana."; RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., RA Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [6] RP CRYSTALLIZATION. RX PubMed=18765915; DOI=10.1107/s1744309108025128; RA Jeong B.C., Yoo K.S., Jung K.W., Shin J.S., Song H.K.; RT "Purification, crystallization and preliminary X-ray diffraction analysis RT of a cystathionine beta-synthase domain-containing protein, CDCP2, from RT Arabidopsis thaliana."; RL Acta Crystallogr. F 64:825-827(2008). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION [LARGE SCALE RP ANALYSIS]. RX PubMed=18431481; DOI=10.1371/journal.pone.0001994; RA Zybailov B., Rutschow H., Friso G., Rudella A., Emanuelsson O., Sun Q., RA van Wijk K.J.; RT "Sorting signals, N-terminal modifications and abundance of the chloroplast RT proteome."; RL PLoS ONE 3:E1994-E1994(2008). RN [8] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=19400948; DOI=10.1186/1471-2164-10-200; RA Kushwaha H.R., Singh A.K., Sopory S.K., Singla-Pareek S.L., Pareek A.; RT "Genome wide expression analysis of CBS domain containing proteins in RT Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their RT developmental and stress regulation."; RL BMC Genomics 10:200-200(2009). RN [9] RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-54, CLEAVAGE OF TRANSIT PEPTIDE RP [LARGE SCALE ANALYSIS] AFTER PRO-53, AND IDENTIFICATION BY MASS RP SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=22223895; DOI=10.1074/mcp.m111.015131; RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., RA Giglione C.; RT "Comparative large-scale characterisation of plant vs. mammal proteins RT reveals similar and idiosyncratic N-alpha acetylation features."; RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012). CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast CC {ECO:0000269|PubMed:18431481}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z99707; CAB16799.1; -; Genomic_DNA. DR EMBL; AL161590; CAB80357.1; -; Genomic_DNA. DR EMBL; CP002687; AEE86716.1; -; Genomic_DNA. DR EMBL; AY085164; AAM61717.1; -; mRNA. DR EMBL; BT003835; AAO41886.1; -; mRNA. DR EMBL; BT005190; AAO50723.1; -; mRNA. DR PIR; H85435; H85435. DR RefSeq; NP_195409.1; NM_119855.4. DR PDB; 4GQV; X-ray; 2.39 A; A=72-236. DR PDB; 4GQW; X-ray; 2.20 A; A=72-134, A=150-236. DR PDBsum; 4GQV; -. DR PDBsum; 4GQW; -. DR AlphaFoldDB; O23193; -. DR SMR; O23193; -. DR BioGRID; 15125; 4. DR IntAct; O23193; 4. DR STRING; 3702.O23193; -. DR iPTMnet; O23193; -. DR PaxDb; 3702-AT4G36910-1; -. DR ProteomicsDB; 239097; -. DR EnsemblPlants; AT4G36910.1; AT4G36910.1; AT4G36910. DR GeneID; 829844; -. DR Gramene; AT4G36910.1; AT4G36910.1; AT4G36910. DR KEGG; ath:AT4G36910; -. DR Araport; AT4G36910; -. DR TAIR; AT4G36910; LEJ2. DR eggNOG; ENOG502QTH1; Eukaryota. DR HOGENOM; CLU_040681_4_0_1; -. DR InParanoid; O23193; -. DR OMA; FRGLHIN; -. DR OrthoDB; 312593at2759; -. DR PhylomeDB; O23193; -. DR PRO; PR:O23193; -. DR Proteomes; UP000006548; Chromosome 4. DR ExpressionAtlas; O23193; baseline and differential. DR GO; GO:0009507; C:chloroplast; IDA:TAIR. DR GO; GO:0045454; P:cell redox homeostasis; IDA:TAIR. DR CDD; cd17789; CBS_pair_plant_CBSX; 1. DR Gene3D; 3.10.580.10; CBS-domain; 1. DR InterPro; IPR000644; CBS_dom. DR InterPro; IPR046342; CBS_dom_sf. DR PANTHER; PTHR48108:SF6; CBS DOMAIN-CONTAINING PROTEIN CBSX1, CHLOROPLASTIC; 1. DR PANTHER; PTHR48108; CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC; 1. DR Pfam; PF00571; CBS; 2. DR SMART; SM00116; CBS; 2. DR SUPFAM; SSF54631; CBS-domain pair; 1. DR PROSITE; PS51371; CBS; 2. DR Genevisible; O23193; AT. PE 1: Evidence at protein level; KW 3D-structure; Acetylation; CBS domain; Chloroplast; Plastid; KW Reference proteome; Repeat; Transit peptide. FT TRANSIT 1..53 FT /note="Chloroplast" FT /evidence="ECO:0007744|PubMed:22223895" FT CHAIN 54..236 FT /note="CBS domain-containing protein CBSX1, chloroplastic" FT /id="PRO_0000403988" FT DOMAIN 81..142 FT /note="CBS 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703" FT DOMAIN 175..231 FT /note="CBS 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00703" FT REGION 47..66 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 54 FT /note="N-acetylserine" FT /evidence="ECO:0007744|PubMed:22223895" FT HELIX 77..79 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 81..84 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 96..105 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 109..114 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 119..125 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 126..129 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 154..160 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 171..174 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 175..178 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 182..187 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 188..197 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 202..206 FT /evidence="ECO:0007829|PDB:4GQW" FT STRAND 210..217 FT /evidence="ECO:0007829|PDB:4GQW" FT HELIX 218..226 FT /evidence="ECO:0007829|PDB:4GQW" SQ SEQUENCE 236 AA; 25769 MW; AE5D224F42A997D9 CRC64; MDAVLYSVPL SFTPLRASSS PSSPYLLLPR FLSVQPCHKF TFSRSFPSKS RIPSASSAAG STLMTNSSSP RSGVYTVGEF MTKKEDLHVV KPTTTVDEAL ELLVENRITG FPVIDEDWKL VGLVSDYDLL ALDSISGSGR TENSMFPEVD STWKTFNAVQ KLLSKTNGKL VGDLMTPAPL VVEEKTNLED AAKILLETKY RRLPVVDSDG KLVGIITRGN VVRAALQIKR SGDRNA //