Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Arginine decarboxylase 2

Gene

ADC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the biosynthesis of putrescine. Catalyzes the first step of polyamine (PA) biosynthesis to produce putrescine from arginine (PubMed:14684170, PubMed:15733873, PubMed:16045477, PubMed:25409942). Is a major contributor to basal arginine decarboxylase (ADC) activity and putrescine biosynthesis (PubMed:25409942). Accumulation of putrescine plays a positive role in salt stress tolerance (PubMed:14684170). Accumulation of putrescine plays a positive role in freezing tolerance (PubMed:18701673). Production of PA is essential for normal seed development (PubMed:15733873). Controls PA homeostasis which is crucial for normal plant growth and development (PubMed:27014322).6 Publications

Miscellaneous

Plants over-expressing ADC2 accumulate very high levels of putrescine and exhibit dwarfism and late-flowering phenotypes.1 Publication

Catalytic activityi

L-arginine = agmatine + CO2.1 Publication

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.Curated
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase 2 (ADC2), Arginine decarboxylase (AXX17_At4g39700), Arginine decarboxylase (AXX17_At2g11570), Arginine decarboxylase 1 (ADC1)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

  • arginine decarboxylase activity Source: TAIR
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

  • arginine catabolic process Source: InterPro
  • polyamine biosynthetic process Source: TAIR
  • putrescine biosynthetic process Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to cold Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to karrikin Source: TAIR
  • response to osmotic stress Source: TAIR
  • response to oxidative stress Source: TAIR
  • response to salt stress Source: TAIR
  • response to wounding Source: TAIR
  • spermidine biosynthetic process Source: UniProtKB-KW

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPutrescine biosynthesis, Spermidine biosynthesis, Stress response
LigandMagnesium, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciARA:AT4G34710-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase 2Curated (EC:4.1.1.191 Publication)
Short name:
ADC 2Curated
Short name:
ARGDC 2Curated
Short name:
AtADC21 Publication
Alternative name(s):
ADC-NCurated
Gene namesi
Name:ADC21 Publication
Synonyms:SPE21 Publication
Ordered Locus Names:At4g34710Imported
ORF Names:T4L20.290Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G34710.
TAIRilocus:2139629. AT4G34710.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Cytoplasm, Plastid

Pathology & Biotechi

Disruption phenotypei

Increased levels of lateral root branching.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499471 – 711Arginine decarboxylase 2Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei147N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiO23141.

PTM databases

iPTMnetiO23141.

Expressioni

Inductioni

Induced by wounding, methyl jasmonate and abscisic acid (ABA) (PubMed:12428010). Induced by salt stress (PubMed:14684170). Induced by osmotic stress (PubMed:10481069). Induced by freezing (PubMed:18701673). Induced by the bacterial pathogen Pseudomonas viridiflava (PubMed:25409942).5 Publications

Gene expression databases

ExpressionAtlasiO23141. baseline and differential.
GenevisibleiO23141. AT.

Interactioni

Subunit structurei

Homodimer and heterodimer with ADC1.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi14905. 1 interactor.
IntActiO23141. 1 interactor.
STRINGi3702.AT4G34710.1.

Structurei

3D structure databases

ProteinModelPortaliO23141.
SMRiO23141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni331 – 341Substrate-bindingBy similarityAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKSU. Eukaryota.
COG1166. LUCA.
HOGENOMiHOG000029191.
InParanoidiO23141.
KOiK01583.
OMAiLFPIMPI.
OrthoDBiEOG09360480.
PhylomeDBiO23141.

Family and domain databases

CDDicd06830. PLPDE_III_ADC. 1 hit.
Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiView protein in InterPro
IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
PANTHERiPTHR43295. PTHR43295. 1 hit.
PfamiView protein in Pfam
PF02784. Orn_Arg_deC_N. 1 hit.
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiView protein in PROSITE
PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.

Sequencei

Sequence statusi: Complete.

O23141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALACVDTS FVPPAYAFSD TAGDVFIPAS SPTSAAVVVD RWSPSLSSSL
60 70 80 90 100
YRIDGWGAPY FIANSSGNIS VRPHGSETLP HQDIDLLKIV KKVTGPKSSG
110 120 130 140 150
GLGLQLPLIV RFPDVLKNRL ECLQSAFDYA IKSQGYDSHY QGVYPVKCNQ
160 170 180 190 200
DRFVVEDIVK FGSSFRFGLE AGSKPEILLA MSCLCKGSPD AFLVCNGFKD
210 220 230 240 250
AEYISLALLG RKLALNTVIV LEQEEELDLV IELSQKMNVR PVIGLRAKLR
260 270 280 290 300
TKHSGHFGST SGEKGKFGLT TTQIVRVVRK LRQSGMLDCL QLLHFHIGSQ
310 320 330 340 350
IPSTSLLSDG VAEAAQLYCE LVRLGAHMKV IDIGGGLGID YDGSKSGESD
360 370 380 390 400
LSVAYSLEEY AEAVVASVRV VCDRSSVKHP VICSESGRAI VSHHSVLIFE
410 420 430 440 450
AVSADKPMVH QATPGDIQFL LEGNEEARAN YEDLYAAVMR GDHESCLLYV
460 470 480 490 500
DQLKQRCVEG FKEGVLSIEQ LASVDGLCEW VLKAIGASDP VHTYNINLSV
510 520 530 540 550
FTSIPDLWGI DQLFPIVPIH KLDQRPGARG ILSDLTCDSD GKINKFIGGE
560 570 580 590 600
SSLPLHELDK NGSGGRYFLG MFLGGAYEEA LGGVHNLFGG PSVVRVSQSD
610 620 630 640 650
GPHSFAVTRA VPGQSSADVL RAMQHEPELM FQTLKHRAEE MMHTKGGSEG
660 670 680 690 700
ENEEEEEDDE FNNVAASLDR SFHNMPYLAT EQASPSNSLS AAISNLGFYY
710
CDEDVYDYIS A
Length:711
Mass (Da):77,219
Last modified:January 1, 1998 - v1
Checksum:i8E003877173DEEE5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54D → Y in AAL09792 (PubMed:14593172).Curated1
Sequence conflicti364V → F in AAN31828 (PubMed:14593172).Curated1
Sequence conflicti461F → Y in AAN31828 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF009647 mRNA. Translation: AAB72179.1.
AL023094 Genomic DNA. Translation: CAA18850.1.
AL161586 Genomic DNA. Translation: CAB80188.1.
CP002687 Genomic DNA. Translation: AEE86413.1.
CP002687 Genomic DNA. Translation: AEE86414.1.
AY039581 mRNA. Translation: AAK62636.1.
AY057553 mRNA. Translation: AAL09792.1.
AY093982 mRNA. Translation: AAM16243.1.
BT000682 mRNA. Translation: AAN31828.1.
PIRiT05291.
RefSeqiNP_195197.1. NM_119637.3.
NP_974684.1. NM_202955.1.
UniGeneiAt.2313.
At.43941.

Genome annotation databases

EnsemblPlantsiAT4G34710.1; AT4G34710.1; AT4G34710.
AT4G34710.2; AT4G34710.2; AT4G34710.
GeneIDi829623.
GrameneiAT4G34710.1; AT4G34710.1; AT4G34710.
AT4G34710.2; AT4G34710.2; AT4G34710.
KEGGiath:AT4G34710.

Similar proteinsi

Entry informationi

Entry nameiSPE2_ARATH
AccessioniPrimary (citable) accession number: O23141
Secondary accession number(s): Q8H165, Q93ZG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: January 1, 1998
Last modified: December 20, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families