Reviewed, UniProtKB/Swiss-Prot O23141 (SPE2_ARATH)

Names and origin

Protein names

Recommended name:
    Arginine decarboxylase 2
      Short name=ARGDC 2
      Short name=ADC 2
    EC=4.1.1.19
Alternative name(s):
    ADC-N

Gene names

Name:	SPE2
Ordered Locus Names:	At4g34710
ORF Names:	T4L20.290

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	711 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-arginine = agmatine + CO2.
Cofactor	Pyridoxal phosphate. Magnesium.
Pathway	Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Putrescine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro putrescine biosynthetic process Inferred from mutant phenotype. Source: TAIR response to abscisic acid stimulus Inferred from expression pattern. Source: TAIR response to cold Inferred from mutant phenotype. Source: TAIR response to jasmonic acid stimulus Inferred from expression pattern. Source: TAIR response to oxidative stress Inferred from expression pattern. Source: TAIR response to salt stress Inferred from mutant phenotype. Source: TAIR response to wounding Inferred from expression pattern. Source: TAIR seed development Inferred from genetic interaction. Source: TAIR spermidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arginine decarboxylase activity Inferred from mutant phenotype. Source: TAIR magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 711	711	Arginine decarboxylase 2		PRO_0000149947
Regions
	Region	331 – 341	11	Substrate-binding By similarity
Amino acid modifications
	Modified residue	147	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	O23141-1 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: 8E003877173DEEE5	FASTA	711	77,219
	10 20 30 40 50 60 MPALACVDTS FVPPAYAFSD TAGDVFIPAS SPTSAAVVVD RWSPSLSSSL YRIDGWGAPY 70 80 90 100 110 120 FIANSSGNIS VRPHGSETLP HQDIDLLKIV KKVTGPKSSG GLGLQLPLIV RFPDVLKNRL 130 140 150 160 170 180 ECLQSAFDYA IKSQGYDSHY QGVYPVKCNQ DRFVVEDIVK FGSSFRFGLE AGSKPEILLA 190 200 210 220 230 240 MSCLCKGSPD AFLVCNGFKD AEYISLALLG RKLALNTVIV LEQEEELDLV IELSQKMNVR 250 260 270 280 290 300 PVIGLRAKLR TKHSGHFGST SGEKGKFGLT TTQIVRVVRK LRQSGMLDCL QLLHFHIGSQ 310 320 330 340 350 360 IPSTSLLSDG VAEAAQLYCE LVRLGAHMKV IDIGGGLGID YDGSKSGESD LSVAYSLEEY 370 380 390 400 410 420 AEAVVASVRV VCDRSSVKHP VICSESGRAI VSHHSVLIFE AVSADKPMVH QATPGDIQFL 430 440 450 460 470 480 LEGNEEARAN YEDLYAAVMR GDHESCLLYV DQLKQRCVEG FKEGVLSIEQ LASVDGLCEW 490 500 510 520 530 540 VLKAIGASDP VHTYNINLSV FTSIPDLWGI DQLFPIVPIH KLDQRPGARG ILSDLTCDSD 550 560 570 580 590 600 GKINKFIGGE SSLPLHELDK NGSGGRYFLG MFLGGAYEEA LGGVHNLFGG PSVVRVSQSD 610 620 630 640 650 660 GPHSFAVTRA VPGQSSADVL RAMQHEPELM FQTLKHRAEE MMHTKGGSEG ENEEEEEDDE 670 680 690 700 710 FNNVAASLDR SFHNMPYLAT EQASPSNSLS AAISNLGFYY CDEDVYDYIS A

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of a second arginine decarboxylase cDNA from Arabidopsis." Watson M.B., Yu W., Galloway G., Malmberg R.L. Plant Gene Register PGR97-114 Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF009647 mRNA. Translation: AAB72179.1. AL023094 Genomic DNA. Translation: CAA18850.1. AL161586 Genomic DNA. Translation: CAB80188.1. AY039581 mRNA. Translation: AAK62636.1. AY093982 mRNA. Translation: AAM16243.1.
IPI	IPI00547586.
PIR	T05291.
RefSeq	NP_195197.1. NP_974684.1.
UniGene	At.2313 At.43941
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	O23141.
Proteomic databases
PRIDE	O23141.
Genome annotation databases
GeneID	829623.
GenomeReviews	Gene locus AT4G34710 in contig CT486007_GR.
KEGG	ath:AT4G34710.
NMPDR	fig|3702.1.peg.21544.
Organism-specific databases
TAIR	At4g34710.
Phylogenomic databases
OMA	ARANREY.
Enzyme and pathway databases
BRENDA	4.1.1.19. 302.
Gene expression databases
Genevestigator	O23141.
GermOnline	AT4G34710. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPE2_ARATH

Accession

Primary (citable) accession number: O23141

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	November 3, 2009
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)