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Protein

Cytochrome c-1

Gene

CYTC-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23Heme (covalent)PROSITE-ProRule annotation1
Binding sitei26Heme (covalent)PROSITE-ProRule annotation1
Metal bindingi27Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi89Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • electron carrier activity Source: InterPro
  • heme binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-111457. Release of apoptotic factors from the mitochondria.
R-ATH-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-1Curated
Alternative name(s):
Cytochrome c At1g22840
Gene namesi
Name:CYTC-1Curated
Ordered Locus Names:At1g22840
ORF Names:F19G10.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G22840.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • mitochondrial intermembrane space Source: GO_Central
  • mitochondrion Source: TAIR
  • respiratory chain Source: UniProtKB-KW
  • vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001082852 – 114Cytochrome c-1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei81N6,N6,N6-trimethyllysineBy similarity1
Modified residuei95N6,N6,N6-trimethyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiO23138.
PRIDEiO23138.

Expressioni

Gene expression databases

ExpressionAtlasiO23138. baseline and differential.
GenevisibleiO23138. AT.

Interactioni

Subunit structurei

Interacts with CCMH (via N-terminus) (PubMed:16236729). Interacts with CCMFN2 (PubMed:18644794).2 Publications

Protein-protein interaction databases

BioGridi24128. 6 interactors.
IntActiO23138. 8 interactors.
STRINGi3702.AT1G22840.1.

Structurei

3D structure databases

ProteinModelPortaliO23138.
SMRiO23138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
HOGENOMiHOG000009762.
InParanoidiO23138.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG09360TD6.
PhylomeDBiO23138.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O23138-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASFDEAPPG NAKAGEKIFR TKCAQCHTVE AGAGHKQGPN LNGLFGRQSG
60 70 80 90 100
TTAGYSYSAA NKNKAVEWEE KALYDYLLNP KKYIPGTKMV FPGLKKPQDR
110
ADLIAYLKES TAPK
Length:114
Mass (Da):12,394
Last modified:January 1, 1998 - v1
Checksum:iAB9E7BD40AFF2C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000657 Genomic DNA. Translation: AAB72175.1.
CP002684 Genomic DNA. Translation: AEE30294.1.
AY062853 mRNA. Translation: AAL32931.1.
AY114580 mRNA. Translation: AAM47899.1.
AY087108 mRNA. Translation: AAM64666.1.
PIRiC86362.
RefSeqiNP_173697.1. NM_102130.4. [O23138-1]
UniGeneiAt.23516.
At.48220.

Genome annotation databases

EnsemblPlantsiAT1G22840.1; AT1G22840.1; AT1G22840. [O23138-1]
GeneIDi838889.
GrameneiAT1G22840.1; AT1G22840.1; AT1G22840.
KEGGiath:AT1G22840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000657 Genomic DNA. Translation: AAB72175.1.
CP002684 Genomic DNA. Translation: AEE30294.1.
AY062853 mRNA. Translation: AAL32931.1.
AY114580 mRNA. Translation: AAM47899.1.
AY087108 mRNA. Translation: AAM64666.1.
PIRiC86362.
RefSeqiNP_173697.1. NM_102130.4. [O23138-1]
UniGeneiAt.23516.
At.48220.

3D structure databases

ProteinModelPortaliO23138.
SMRiO23138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24128. 6 interactors.
IntActiO23138. 8 interactors.
STRINGi3702.AT1G22840.1.

Proteomic databases

PaxDbiO23138.
PRIDEiO23138.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G22840.1; AT1G22840.1; AT1G22840. [O23138-1]
GeneIDi838889.
GrameneiAT1G22840.1; AT1G22840.1; AT1G22840.
KEGGiath:AT1G22840.

Organism-specific databases

TAIRiAT1G22840.

Phylogenomic databases

eggNOGiKOG3453. Eukaryota.
COG3474. LUCA.
HOGENOMiHOG000009762.
InParanoidiO23138.
KOiK08738.
OMAiWNEETLM.
OrthoDBiEOG09360TD6.
PhylomeDBiO23138.

Enzyme and pathway databases

ReactomeiR-ATH-111457. Release of apoptotic factors from the mitochondria.
R-ATH-3299685. Detoxification of Reactive Oxygen Species.

Miscellaneous databases

PROiO23138.

Gene expression databases

ExpressionAtlasiO23138. baseline and differential.
GenevisibleiO23138. AT.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYC1_ARATH
AccessioniPrimary (citable) accession number: O23138
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.