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O23138

- CYC2_ARATH

UniProt

O23138 - CYC2_ARATH

Protein

Probable cytochrome c At1g22840

Gene

At1g22840

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei23 – 231Heme (covalent)PROSITE-ProRule annotation
    Binding sitei26 – 261Heme (covalent)PROSITE-ProRule annotation
    Metal bindingi27 – 271Iron (heme axial ligand)PROSITE-ProRule annotation
    Metal bindingi89 – 891Iron (heme axial ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. copper ion binding Source: TAIR
    2. electron carrier activity Source: InterPro
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: TAIR
    2. oxidation-reduction process Source: UniProtKB-KW

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_180046. Detoxification of Reactive Oxygen Species.
    REACT_185561. Release of apoptotic factors from the mitochondria.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c At1g22840
    Gene namesi
    Ordered Locus Names:At1g22840
    ORF Names:F19G10.20
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G22840.

    Subcellular locationi

    Mitochondrion intermembrane space 1 Publication
    Note: Loosely associated with the inner membrane.

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. mitochondrion Source: TAIR
    4. respiratory chain Source: UniProtKB-KW
    5. vacuolar membrane Source: TAIR

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 114113Probable cytochrome c At1g22840PRO_0000108285Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei81 – 811N6,N6,N6-trimethyllysineBy similarity
    Modified residuei95 – 951N6,N6,N6-trimethyllysineBy similarity

    Post-translational modificationi

    Binds 1 heme group per subunit.By similarity

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    PaxDbiO23138.
    PRIDEiO23138.

    Expressioni

    Gene expression databases

    ArrayExpressiO23138.
    GenevestigatoriO23138.

    Interactioni

    Protein-protein interaction databases

    BioGridi24128. 6 interactions.
    IntActiO23138. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliO23138.
    SMRiO23138. Positions 2-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome c family.Curated

    Phylogenomic databases

    eggNOGiCOG3474.
    HOGENOMiHOG000009762.
    InParanoidiO23138.
    KOiK08738.
    OMAiRQARAND.
    PhylomeDBiO23138.

    Family and domain databases

    Gene3Di1.10.760.10. 1 hit.
    InterProiIPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view]
    PANTHERiPTHR11961. PTHR11961. 1 hit.
    PfamiPF00034. Cytochrom_C. 1 hit.
    [Graphical view]
    PRINTSiPR00604. CYTCHRMECIAB.
    SUPFAMiSSF46626. SSF46626. 1 hit.
    PROSITEiPS51007. CYTC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: O23138-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASFDEAPPG NAKAGEKIFR TKCAQCHTVE AGAGHKQGPN LNGLFGRQSG    50
    TTAGYSYSAA NKNKAVEWEE KALYDYLLNP KKYIPGTKMV FPGLKKPQDR 100
    ADLIAYLKES TAPK 114
    Length:114
    Mass (Da):12,394
    Last modified:January 1, 1998 - v1
    Checksum:iAB9E7BD40AFF2C62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000657 Genomic DNA. Translation: AAB72175.1.
    CP002684 Genomic DNA. Translation: AEE30294.1.
    AY062853 mRNA. Translation: AAL32931.1.
    AY114580 mRNA. Translation: AAM47899.1.
    AY087108 mRNA. Translation: AAM64666.1.
    PIRiC86362.
    RefSeqiNP_173697.1. NM_102130.4. [O23138-1]
    UniGeneiAt.23516.
    At.48220.

    Genome annotation databases

    EnsemblPlantsiAT1G22840.1; AT1G22840.1; AT1G22840. [O23138-1]
    GeneIDi838889.
    KEGGiath:AT1G22840.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Life shuttle - Issue 76 of November 2006

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF000657 Genomic DNA. Translation: AAB72175.1 .
    CP002684 Genomic DNA. Translation: AEE30294.1 .
    AY062853 mRNA. Translation: AAL32931.1 .
    AY114580 mRNA. Translation: AAM47899.1 .
    AY087108 mRNA. Translation: AAM64666.1 .
    PIRi C86362.
    RefSeqi NP_173697.1. NM_102130.4. [O23138-1 ]
    UniGenei At.23516.
    At.48220.

    3D structure databases

    ProteinModelPortali O23138.
    SMRi O23138. Positions 2-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 24128. 6 interactions.
    IntActi O23138. 8 interactions.

    Proteomic databases

    PaxDbi O23138.
    PRIDEi O23138.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G22840.1 ; AT1G22840.1 ; AT1G22840 . [O23138-1 ]
    GeneIDi 838889.
    KEGGi ath:AT1G22840.

    Organism-specific databases

    GeneFarmi 1711. 128.
    TAIRi AT1G22840.

    Phylogenomic databases

    eggNOGi COG3474.
    HOGENOMi HOG000009762.
    InParanoidi O23138.
    KOi K08738.
    OMAi RQARAND.
    PhylomeDBi O23138.

    Enzyme and pathway databases

    Reactomei REACT_180046. Detoxification of Reactive Oxygen Species.
    REACT_185561. Release of apoptotic factors from the mitochondria.

    Gene expression databases

    ArrayExpressi O23138.
    Genevestigatori O23138.

    Family and domain databases

    Gene3Di 1.10.760.10. 1 hit.
    InterProi IPR009056. Cyt_c-like_dom.
    IPR002327. Cyt_c_1A/1B.
    IPR003088. Cyt_c_dom.
    [Graphical view ]
    PANTHERi PTHR11961. PTHR11961. 1 hit.
    Pfami PF00034. Cytochrom_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00604. CYTCHRMECIAB.
    SUPFAMi SSF46626. SSF46626. 1 hit.
    PROSITEi PS51007. CYTC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.
    6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCYC2_ARATH
    AccessioniPrimary (citable) accession number: O23138
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3