Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c-1

Gene

CYTC-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23Heme (covalent)PROSITE-ProRule annotation1
Binding sitei26Heme (covalent)PROSITE-ProRule annotation1
Metal bindingi27Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi89Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • copper ion binding Source: TAIR
  • electron transfer activity Source: InterPro
  • heme binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-111457 Release of apoptotic factors from the mitochondria
R-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-1Curated
Alternative name(s):
Cytochrome c At1g22840
Gene namesi
Name:CYTC-1Curated
Ordered Locus Names:At1g22840
ORF Names:F19G10.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G22840
TAIRilocus:2017729 AT1G22840

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001082852 – 114Cytochrome c-1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei81N6,N6,N6-trimethyllysineBy similarity1
Modified residuei95N6,N6,N6-trimethyllysineBy similarity1

Post-translational modificationi

Binds 1 heme group per subunit.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiO23138
PRIDEiO23138

PTM databases

iPTMnetiO23138

Expressioni

Gene expression databases

ExpressionAtlasiO23138 baseline and differential
GenevisibleiO23138 AT

Interactioni

Subunit structurei

Interacts with CCMH (via N-terminus) (PubMed:16236729). Interacts with CCMFN2 (PubMed:18644794).2 Publications

Protein-protein interaction databases

BioGridi24128, 6 interactors
IntActiO23138, 8 interactors
STRINGi3702.AT1G22840.1

Structurei

3D structure databases

ProteinModelPortaliO23138
SMRiO23138
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.Curated

Phylogenomic databases

eggNOGiKOG3453 Eukaryota
COG3474 LUCA
HOGENOMiHOG000009762
InParanoidiO23138
KOiK08738
OMAiGLFKTRC
OrthoDBiEOG09360TD6
PhylomeDBiO23138

Family and domain databases

Gene3Di1.10.760.10, 1 hit
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR002327 Cyt_c_1A/1B
PANTHERiPTHR11961 PTHR11961, 1 hit
PfamiView protein in Pfam
PF00034 Cytochrom_C, 1 hit
PRINTSiPR00604 CYTCHRMECIAB
SUPFAMiSSF46626 SSF46626, 1 hit
PROSITEiView protein in PROSITE
PS51007 CYTC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: O23138-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASFDEAPPG NAKAGEKIFR TKCAQCHTVE AGAGHKQGPN LNGLFGRQSG
60 70 80 90 100
TTAGYSYSAA NKNKAVEWEE KALYDYLLNP KKYIPGTKMV FPGLKKPQDR
110
ADLIAYLKES TAPK
Length:114
Mass (Da):12,394
Last modified:January 1, 1998 - v1
Checksum:iAB9E7BD40AFF2C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000657 Genomic DNA Translation: AAB72175.1
CP002684 Genomic DNA Translation: AEE30294.1
AY062853 mRNA Translation: AAL32931.1
AY114580 mRNA Translation: AAM47899.1
AY087108 mRNA Translation: AAM64666.1
PIRiC86362
RefSeqiNP_173697.1, NM_102130.4 [O23138-1]
UniGeneiAt.23516
At.48220

Genome annotation databases

EnsemblPlantsiAT1G22840.1; AT1G22840.1; AT1G22840 [O23138-1]
GeneIDi838889
GrameneiAT1G22840.1; AT1G22840.1; AT1G22840 [O23138-1]
KEGGiath:AT1G22840

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCYC1_ARATH
AccessioniPrimary (citable) accession number: O23138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health