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O23138

- CYC2_ARATH

UniProt

O23138 - CYC2_ARATH

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Protein
Probable cytochrome c At1g22840
Gene
At1g22840, F19G10.20
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231Heme (covalent) By similarity
Binding sitei26 – 261Heme (covalent) By similarity
Metal bindingi27 – 271Iron (heme axial ligand) By similarity
Metal bindingi89 – 891Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: TAIR
  2. electron carrier activity Source: InterPro
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. cell proliferation Source: TAIR
  2. oxidation-reduction process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_180046. Detoxification of Reactive Oxygen Species.
REACT_185561. Release of apoptotic factors from the mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c At1g22840
Gene namesi
Ordered Locus Names:At1g22840
ORF Names:F19G10.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G22840.

Subcellular locationi

Mitochondrion intermembrane space
Note: Loosely associated with the inner membrane.1 Publication

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. mitochondrial intermembrane space Source: UniProtKB-SubCell
  3. mitochondrion Source: TAIR
  4. respiratory chain Source: UniProtKB-KW
  5. vacuolar membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 114113Probable cytochrome c At1g22840
PRO_0000108285Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei81 – 811N6,N6,N6-trimethyllysine By similarity
Modified residuei95 – 951N6,N6,N6-trimethyllysine By similarity

Post-translational modificationi

Binds 1 heme group per subunit By similarity.

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiO23138.
PRIDEiO23138.

Expressioni

Gene expression databases

ArrayExpressiO23138.
GenevestigatoriO23138.

Interactioni

Protein-protein interaction databases

BioGridi24128. 6 interactions.
IntActiO23138. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliO23138.
SMRiO23138. Positions 2-112.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome c family.

Phylogenomic databases

eggNOGiCOG3474.
HOGENOMiHOG000009762.
InParanoidiO23138.
KOiK08738.
OMAiRQARAND.
PhylomeDBiO23138.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view]
PANTHERiPTHR11961. PTHR11961. 1 hit.
PfamiPF00034. Cytochrom_C. 1 hit.
[Graphical view]
PRINTSiPR00604. CYTCHRMECIAB.
SUPFAMiSSF46626. SSF46626. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: O23138-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASFDEAPPG NAKAGEKIFR TKCAQCHTVE AGAGHKQGPN LNGLFGRQSG    50
TTAGYSYSAA NKNKAVEWEE KALYDYLLNP KKYIPGTKMV FPGLKKPQDR 100
ADLIAYLKES TAPK 114
Length:114
Mass (Da):12,394
Last modified:January 1, 1998 - v1
Checksum:iAB9E7BD40AFF2C62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000657 Genomic DNA. Translation: AAB72175.1.
CP002684 Genomic DNA. Translation: AEE30294.1.
AY062853 mRNA. Translation: AAL32931.1.
AY114580 mRNA. Translation: AAM47899.1.
AY087108 mRNA. Translation: AAM64666.1.
PIRiC86362.
RefSeqiNP_173697.1. NM_102130.4. [O23138-1]
UniGeneiAt.23516.
At.48220.

Genome annotation databases

EnsemblPlantsiAT1G22840.1; AT1G22840.1; AT1G22840. [O23138-1]
GeneIDi838889.
KEGGiath:AT1G22840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF000657 Genomic DNA. Translation: AAB72175.1 .
CP002684 Genomic DNA. Translation: AEE30294.1 .
AY062853 mRNA. Translation: AAL32931.1 .
AY114580 mRNA. Translation: AAM47899.1 .
AY087108 mRNA. Translation: AAM64666.1 .
PIRi C86362.
RefSeqi NP_173697.1. NM_102130.4. [O23138-1 ]
UniGenei At.23516.
At.48220.

3D structure databases

ProteinModelPortali O23138.
SMRi O23138. Positions 2-112.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 24128. 6 interactions.
IntActi O23138. 8 interactions.

Proteomic databases

PaxDbi O23138.
PRIDEi O23138.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G22840.1 ; AT1G22840.1 ; AT1G22840 . [O23138-1 ]
GeneIDi 838889.
KEGGi ath:AT1G22840.

Organism-specific databases

GeneFarmi 1711. 128.
TAIRi AT1G22840.

Phylogenomic databases

eggNOGi COG3474.
HOGENOMi HOG000009762.
InParanoidi O23138.
KOi K08738.
OMAi RQARAND.
PhylomeDBi O23138.

Enzyme and pathway databases

Reactomei REACT_180046. Detoxification of Reactive Oxygen Species.
REACT_185561. Release of apoptotic factors from the mitochondria.

Gene expression databases

ArrayExpressi O23138.
Genevestigatori O23138.

Family and domain databases

Gene3Di 1.10.760.10. 1 hit.
InterProi IPR009056. Cyt_c-like_dom.
IPR002327. Cyt_c_1A/1B.
IPR003088. Cyt_c_dom.
[Graphical view ]
PANTHERi PTHR11961. PTHR11961. 1 hit.
Pfami PF00034. Cytochrom_C. 1 hit.
[Graphical view ]
PRINTSi PR00604. CYTCHRMECIAB.
SUPFAMi SSF46626. SSF46626. 1 hit.
PROSITEi PS51007. CYTC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCYC2_ARATH
AccessioniPrimary (citable) accession number: O23138
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: January 1, 1998
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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