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Protein

CBL-interacting serine/threonine-protein kinase 13

Gene

CIPK13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei86ATPPROSITE-ProRule annotation1
Active sitei179Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 71ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CBL-interacting serine/threonine-protein kinase 13 (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase 3.7
SOS2-like protein kinase PKS10
Gene namesi
Name:CIPK13
Synonyms:PKS10, SnRK3.7
Ordered Locus Names:At2g34180
ORF Names:F13P17.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G34180
TAIRilocus:2040824 AT2G34180

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003372151 – 502CBL-interacting serine/threonine-protein kinase 13Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei215PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiO22971
PRIDEiO22971

Expressioni

Gene expression databases

ExpressionAtlasiO22971 baseline and differential
GenevisibleiO22971 AT

Interactioni

Subunit structurei

Interacts with CBL2 and CBL3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBL2Q8LAS74EBI-637402,EBI-485991

Protein-protein interaction databases

BioGridi3326, 6 interactors
IntActiO22971, 2 interactors
STRINGi3702.AT2G34180.1

Structurei

3D structure databases

ProteinModelPortaliO22971
SMRiO22971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 311Protein kinasePROSITE-ProRule annotationAdd BLAST255
Domaini366 – 387NAFPROSITE-ProRule annotationAdd BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 226Activation loopBy similarityAdd BLAST30
Regioni390 – 419PPIBy similarityAdd BLAST30

Domaini

The activation loop within the kinase domain is the target of phosphorylation/activation by upstream protein kinases. The PPI motif mediates the interaction with the ABI (abscisic acid-insensitive) phosphatases (By similarity).By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0583 Eukaryota
COG0515 LUCA
HOGENOMiHOG000233016
InParanoidiO22971
OMAiPKTTQGS
OrthoDBiEOG093609MZ
PhylomeDBiO22971

Family and domain databases

InterProiView protein in InterPro
IPR020636 Ca/CaM-dep_Ca-dep_prot_Kinase
IPR011009 Kinase-like_dom_sf
IPR018451 NAF/FISL_domain
IPR004041 NAF_dom
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR43895 PTHR43895, 1 hit
PfamiView protein in Pfam
PF03822 NAF, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50816 NAF, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

O22971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVLSTPLA IPGPTPIQFM AGLLARIVTK NTNKETSTPE SPRSPRTPQG
60 70 80 90 100
SILMDKYEIG KLLGHGSFAK VYLARNIHSG EDVAIKVIDK EKIVKSGLAG
110 120 130 140 150
HIKREISILR RVRHPYIVHL LEVMATKTKI YIVMEYVRGG ELYNTVARGR
160 170 180 190 200
LREGTARRYF QQLISSVAFC HSRGVYHRDL KLENLLLDDK GNVKVSDFGL
210 220 230 240 250
SVVSEQLKQE GICQTFCGTP AYLAPEVLTR KGYEGAKADI WSCGVILFVL
260 270 280 290 300
MAGYLPFDDK NILVMYTKIY KGQFKCPKWF SPELARLVTR MLDTNPDTRI
310 320 330 340 350
TIPEIMKHRW FKKGFKHVKF YIENDKLCRE DDDNDDDDSS SLSSGRSSTA
360 370 380 390 400
SEGDAEFDIK RVDSMPRPAS LNAFDILSFS DLSGLFEEGG QGARFVSAAP
410 420 430 440 450
MTKIISKLEE IAKEVKFMVR KKDWSVRLEG CREGAKGPLT IRVEIFELTP
460 470 480 490 500
SLVVVEVKKK GGNIEEYEEF CNKELRPQLE KLMHYQADEV EEVMCLPPEI

EQ
Length:502
Mass (Da):56,731
Last modified:August 1, 1999 - v2
Checksum:iC74597664AAA3C09
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF295668 mRNA Translation: AAK16688.1
AC004481 Genomic DNA Translation: AAC27394.1
CP002685 Genomic DNA Translation: AEC08929.1
PIRiT02306
RefSeqiNP_180965.1, NM_128969.2
UniGeneiAt.43061
At.64959

Genome annotation databases

EnsemblPlantsiAT2G34180.1; AT2G34180.1; AT2G34180
GeneIDi817979
GrameneiAT2G34180.1; AT2G34180.1; AT2G34180
KEGGiath:AT2G34180

Similar proteinsi

Entry informationi

Entry nameiCIPKD_ARATH
AccessioniPrimary (citable) accession number: O22971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: August 1, 1999
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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