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Protein

Peroxidase 19

Gene

PER19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei78Transition state stabilizerPROSITE-ProRule annotation1
Active sitei82Proton acceptorPROSITE-ProRule annotation1
Metal bindingi83Calcium 1PROSITE-ProRule annotation1
Metal bindingi86Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi88Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi90Calcium 1PROSITE-ProRule annotation1
Metal bindingi92Calcium 1PROSITE-ProRule annotation1
Binding sitei182Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi212Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi213Calcium 2PROSITE-ProRule annotation1
Metal bindingi265Calcium 2PROSITE-ProRule annotation1
Metal bindingi268Calcium 2PROSITE-ProRule annotation1
Metal bindingi273Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G34060-MONOMER.

Protein family/group databases

PeroxiBasei100. AtPrx19.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 19 (EC:1.11.1.7)
Short name:
Atperox P19
Alternative name(s):
ATP51
Gene namesi
Name:PER19
Synonyms:P19
Ordered Locus Names:At2g34060
ORF Names:T14G11.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G34060.

Subcellular locationi

  • Secreted PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002368532 – 346Peroxidase 19Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 134PROSITE-ProRule annotation
Disulfide bondi84 ↔ 89PROSITE-ProRule annotation
Disulfide bondi140 ↔ 342PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi219 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO22959.
PRIDEiO22959.

PTM databases

iPTMnetiO22959.

Expressioni

Gene expression databases

GenevisibleiO22959. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G34060.1.

Structurei

3D structure databases

ProteinModelPortaliO22959.
SMRiO22959.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHK0. Eukaryota.
ENOG410YCA9. LUCA.
HOGENOMiHOG000237556.
InParanoidiO22959.
KOiK00430.
OMAiPRVERDM.
OrthoDBiEOG09360IU3.
PhylomeDBiO22959.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVISLSLSS IFFFLFLTST ILISPVQPTT SKPPAPRPHR ELSADYYSKK
60 70 80 90 100
CPQLETLVGS VTSQRFKEVP ISAPATIRLF FHDCFVEGCD GSILIETKKG
110 120 130 140 150
SKKLAEREAY ENKELREEGF DSIIKAKALV ESHCPSLVSC SDILAIAARD
160 170 180 190 200
FIHLAGGPYY QVKKGRWDGK RSTAKNVPPN IPRSNSTVDQ LIKLFASKGL
210 220 230 240 250
TVEELVVLSG SHTIGFAHCK NFLGRLYDYK GTKRPDPSLD QRLLKELRMS
260 270 280 290 300
CPFSGGSSGV VLPLDATTPF VFDNGYFTGL GTNMGLLGSD QALFLDPRTK
310 320 330 340
PIALEMARDK QKFLKAFGDA MDKMGSIGVK RGKRHGEIRT DCRVFL
Length:346
Mass (Da):38,228
Last modified:January 1, 1998 - v1
Checksum:i85D43E7B4C17A814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002341 Genomic DNA. Translation: AAB67624.1.
CP002685 Genomic DNA. Translation: AEC08912.1.
AY080602 mRNA. Translation: AAL86286.1.
BT002341 mRNA. Translation: AAN86174.1.
PIRiH84751.
RefSeqiNP_180953.1. NM_128957.4.
UniGeneiAt.37862.

Genome annotation databases

EnsemblPlantsiAT2G34060.1; AT2G34060.1; AT2G34060.
GeneIDi817967.
GrameneiAT2G34060.1; AT2G34060.1; AT2G34060.
KEGGiath:AT2G34060.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002341 Genomic DNA. Translation: AAB67624.1.
CP002685 Genomic DNA. Translation: AEC08912.1.
AY080602 mRNA. Translation: AAL86286.1.
BT002341 mRNA. Translation: AAN86174.1.
PIRiH84751.
RefSeqiNP_180953.1. NM_128957.4.
UniGeneiAt.37862.

3D structure databases

ProteinModelPortaliO22959.
SMRiO22959.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G34060.1.

Protein family/group databases

PeroxiBasei100. AtPrx19.

PTM databases

iPTMnetiO22959.

Proteomic databases

PaxDbiO22959.
PRIDEiO22959.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G34060.1; AT2G34060.1; AT2G34060.
GeneIDi817967.
GrameneiAT2G34060.1; AT2G34060.1; AT2G34060.
KEGGiath:AT2G34060.

Organism-specific databases

TAIRiAT2G34060.

Phylogenomic databases

eggNOGiENOG410IHK0. Eukaryota.
ENOG410YCA9. LUCA.
HOGENOMiHOG000237556.
InParanoidiO22959.
KOiK00430.
OMAiPRVERDM.
OrthoDBiEOG09360IU3.
PhylomeDBiO22959.

Enzyme and pathway databases

BioCyciARA:AT2G34060-MONOMER.

Miscellaneous databases

PROiO22959.

Gene expression databases

GenevisibleiO22959. AT.

Family and domain databases

CDDicd00693. secretory_peroxidase. 1 hit.
InterProiIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
IPR033905. Secretory_peroxidase.
[Graphical view]
PfamiPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSiPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMiSSF48113. SSF48113. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPER19_ARATH
AccessioniPrimary (citable) accession number: O22959
Secondary accession number(s): Q8RXZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.