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Protein

Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3

Gene

PXC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Leucine-rich repeat receptor-like protein kinase that may play a role in vascular tissues development.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei636ATPPROSITE-ProRule annotation1
Active sitei735Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi614 – 622ATPPROSITE-ProRule annotation9

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3Curated (EC:2.7.10.1)
Alternative name(s):
Protein PXY/TDR-CORRELATED 31 Publication
Gene namesi
Name:PXC31 Publication
Ordered Locus Names:At2g41820
ORF Names:T11A7.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G41820.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 534ExtracellularSequence analysisAdd BLAST511
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21
Topological domaini556 – 890CytoplasmicSequence analysisAdd BLAST335

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000040332524 – 890Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3Add BLAST867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...)Sequence analysis1
Glycosylationi61N-linked (GlcNAc...)Sequence analysis1
Glycosylationi78N-linked (GlcNAc...)Sequence analysis1
Glycosylationi108N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi171N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi276N-linked (GlcNAc...)Sequence analysis1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi303N-linked (GlcNAc...)Sequence analysis1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Glycosylationi429N-linked (GlcNAc...)Sequence analysis1
Glycosylationi477N-linked (GlcNAc...)Sequence analysis1
Glycosylationi498N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO22938.
PRIDEiO22938.

Expressioni

Tissue specificityi

Expressed in the vascular strands of cotyledons, the shoot apex, hypocotyls, roots, leaves, stems and flowers.1 Publication

Gene expression databases

GenevisibleiO22938. AT.

Interactioni

Protein-protein interaction databases

BioGridi4118. 58 interactors.
STRINGi3702.AT2G41820.1.

Structurei

3D structure databases

ProteinModelPortaliO22938.
SMRiO22938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati67 – 85LRR 1Add BLAST19
Repeati86 – 108LRR 2Add BLAST23
Repeati110 – 132LRR 3Add BLAST23
Repeati133 – 157LRR 4Add BLAST25
Repeati159 – 181LRR 5Add BLAST23
Repeati182 – 205LRR 6Add BLAST24
Repeati206 – 229LRR 7Add BLAST24
Repeati231 – 254LRR 8Add BLAST24
Repeati256 – 276LRR 9Add BLAST21
Repeati278 – 300LRR 10Add BLAST23
Repeati301 – 325LRR 11Add BLAST25
Repeati326 – 349LRR 12Add BLAST24
Repeati350 – 373LRR 13Add BLAST24
Repeati375 – 397LRR 14Add BLAST23
Repeati399 – 421LRR 15Add BLAST23
Repeati422 – 446LRR 16Add BLAST25
Repeati447 – 469LRR 17Add BLAST23
Repeati471 – 492LRR 18Add BLAST22
Domaini608 – 886Protein kinasePROSITE-ProRule annotationAdd BLAST279

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 18 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE1. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiO22938.
OMAiHEIGNCV.
OrthoDBiEOG0936024J.
PhylomeDBiO22938.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFWCMSILL IVGFLSKSEL CEAQLSDEAT LVAINRELGV PGWSSNGTDY
60 70 80 90 100
CTWVGLKCGV NNSFVEMLDL SGLQLRGNVT LISDLRSLKH LDLSGNNFNG
110 120 130 140 150
RIPTSFGNLS ELEFLDLSLN RFVGAIPVEF GKLRGLRAFN ISNNLLVGEI
160 170 180 190 200
PDELKVLERL EEFQVSGNGL NGSIPHWVGN LSSLRVFTAY ENDLVGEIPN
210 220 230 240 250
GLGLVSELEL LNLHSNQLEG KIPKGIFEKG KLKVLVLTQN RLTGELPEAV
260 270 280 290 300
GICSGLSSIR IGNNELVGVI PRTIGNISGL TYFEADKNNL SGEIVAEFSK
310 320 330 340 350
CSNLTLLNLA ANGFAGTIPT ELGQLINLQE LILSGNSLFG EIPKSFLGSG
360 370 380 390 400
NLNKLDLSNN RLNGTIPKEL CSMPRLQYLL LDQNSIRGDI PHEIGNCVKL
410 420 430 440 450
LQLQLGRNYL TGTIPPEIGR MRNLQIALNL SFNHLHGSLP PELGKLDKLV
460 470 480 490 500
SLDVSNNLLT GSIPPLLKGM MSLIEVNFSN NLLNGPVPVF VPFQKSPNSS
510 520 530 540 550
FLGNKELCGA PLSSSCGYSE DLDHLRYNHR VSYRIVLAVI GSGVAVFVSV
560 570 580 590 600
TVVVLLFMMR EKQEKAAAKN VDVEENVEDE QPAIIAGNVF LENLKQGIDL
610 620 630 640 650
DAVVKATMKE SNKLSTGTFS SVYKAVMPSG MIVSVKKLKS MDRAISHHQN
660 670 680 690 700
KMIRELERLS KLCHDHLVRP IGFVIYEDVA LLLHQHLPNG NLTQLIHEST
710 720 730 740 750
KKPEYQPDWP MRLSIAVGAA EGLAFLHQVA IIHLDVSSSN VLLDSGYKAV
760 770 780 790 800
LGEIEISKLL DPSRGTASIS SVAGSFGYIP PEYAYTMQVT APGNVYSYGV
810 820 830 840 850
VLLEILTSRA PVEEEFGEGV DLVKWVHGAS ARGETPEQIL DAKLSTVSFA
860 870 880 890
WRREMLAALK VALLCTDITP AKRPKMKKVV EMLQEVKQIK
Length:890
Mass (Da):97,245
Last modified:January 1, 1998 - v1
Checksum:iD43D2B4C848DA568
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti240N → S in BAF00244 (Ref. 4) Curated1
Sequence conflicti818E → G in BAF00244 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002339 Genomic DNA. Translation: AAC02766.1.
CP002685 Genomic DNA. Translation: AEC10036.1.
FJ708712 mRNA. Translation: ACN59307.1.
AK228301 mRNA. Translation: BAF00244.1.
PIRiE84846.
RefSeqiNP_181713.1. NM_129746.3.
UniGeneiAt.43213.

Genome annotation databases

EnsemblPlantsiAT2G41820.1; AT2G41820.1; AT2G41820.
GeneIDi818781.
GrameneiAT2G41820.1; AT2G41820.1; AT2G41820.
KEGGiath:AT2G41820.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002339 Genomic DNA. Translation: AAC02766.1.
CP002685 Genomic DNA. Translation: AEC10036.1.
FJ708712 mRNA. Translation: ACN59307.1.
AK228301 mRNA. Translation: BAF00244.1.
PIRiE84846.
RefSeqiNP_181713.1. NM_129746.3.
UniGeneiAt.43213.

3D structure databases

ProteinModelPortaliO22938.
SMRiO22938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4118. 58 interactors.
STRINGi3702.AT2G41820.1.

Proteomic databases

PaxDbiO22938.
PRIDEiO22938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G41820.1; AT2G41820.1; AT2G41820.
GeneIDi818781.
GrameneiAT2G41820.1; AT2G41820.1; AT2G41820.
KEGGiath:AT2G41820.

Organism-specific databases

TAIRiAT2G41820.

Phylogenomic databases

eggNOGiENOG410IHE1. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiO22938.
OMAiHEIGNCV.
OrthoDBiEOG0936024J.
PhylomeDBiO22938.

Miscellaneous databases

PROiO22938.

Gene expression databases

GenevisibleiO22938. AT.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPXC3_ARATH
AccessioniPrimary (citable) accession number: O22938
Secondary accession number(s): Q0WRK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 1, 1998
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.