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Protein

Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3

Gene

PXC3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Leucine-rich repeat receptor-like protein kinase that may play a role in vascular tissues development.By similarity

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei636 – 6361ATPPROSITE-ProRule annotation
Active sitei735 – 7351Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi614 – 6229ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G41820-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3Curated (EC:2.7.10.1)
Alternative name(s):
Protein PXY/TDR-CORRELATED 31 Publication
Gene namesi
Name:PXC31 Publication
Ordered Locus Names:At2g41820
ORF Names:T11A7.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G41820.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini24 – 534511ExtracellularSequence analysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence analysisAdd
BLAST
Topological domaini556 – 890335CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 890867Leucine-rich repeat receptor-like tyrosine-protein kinase PXC3PRO_0000403325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi61 – 611N-linked (GlcNAc...)Sequence analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Glycosylationi108 – 1081N-linked (GlcNAc...)Sequence analysis
Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence analysis
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)Sequence analysis
Glycosylationi289 – 2891N-linked (GlcNAc...)Sequence analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)Sequence analysis
Glycosylationi363 – 3631N-linked (GlcNAc...)Sequence analysis
Glycosylationi429 – 4291N-linked (GlcNAc...)Sequence analysis
Glycosylationi477 – 4771N-linked (GlcNAc...)Sequence analysis
Glycosylationi498 – 4981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO22938.
PRIDEiO22938.

Expressioni

Tissue specificityi

Expressed in the vascular strands of cotyledons, the shoot apex, hypocotyls, roots, leaves, stems and flowers.1 Publication

Gene expression databases

GenevisibleiO22938. AT.

Interactioni

Protein-protein interaction databases

BioGridi4118. 58 interactions.
STRINGi3702.AT2G41820.1.

Structurei

3D structure databases

ProteinModelPortaliO22938.
SMRiO22938. Positions 19-488, 614-887.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati67 – 8519LRR 1Add
BLAST
Repeati86 – 10823LRR 2Add
BLAST
Repeati110 – 13223LRR 3Add
BLAST
Repeati133 – 15725LRR 4Add
BLAST
Repeati159 – 18123LRR 5Add
BLAST
Repeati182 – 20524LRR 6Add
BLAST
Repeati206 – 22924LRR 7Add
BLAST
Repeati231 – 25424LRR 8Add
BLAST
Repeati256 – 27621LRR 9Add
BLAST
Repeati278 – 30023LRR 10Add
BLAST
Repeati301 – 32525LRR 11Add
BLAST
Repeati326 – 34924LRR 12Add
BLAST
Repeati350 – 37324LRR 13Add
BLAST
Repeati375 – 39723LRR 14Add
BLAST
Repeati399 – 42123LRR 15Add
BLAST
Repeati422 – 44625LRR 16Add
BLAST
Repeati447 – 46923LRR 17Add
BLAST
Repeati471 – 49222LRR 18Add
BLAST
Domaini608 – 886279Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 18 LRR (leucine-rich) repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHE1. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiO22938.
OMAiHEIGNCV.
PhylomeDBiO22938.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTFWCMSILL IVGFLSKSEL CEAQLSDEAT LVAINRELGV PGWSSNGTDY
60 70 80 90 100
CTWVGLKCGV NNSFVEMLDL SGLQLRGNVT LISDLRSLKH LDLSGNNFNG
110 120 130 140 150
RIPTSFGNLS ELEFLDLSLN RFVGAIPVEF GKLRGLRAFN ISNNLLVGEI
160 170 180 190 200
PDELKVLERL EEFQVSGNGL NGSIPHWVGN LSSLRVFTAY ENDLVGEIPN
210 220 230 240 250
GLGLVSELEL LNLHSNQLEG KIPKGIFEKG KLKVLVLTQN RLTGELPEAV
260 270 280 290 300
GICSGLSSIR IGNNELVGVI PRTIGNISGL TYFEADKNNL SGEIVAEFSK
310 320 330 340 350
CSNLTLLNLA ANGFAGTIPT ELGQLINLQE LILSGNSLFG EIPKSFLGSG
360 370 380 390 400
NLNKLDLSNN RLNGTIPKEL CSMPRLQYLL LDQNSIRGDI PHEIGNCVKL
410 420 430 440 450
LQLQLGRNYL TGTIPPEIGR MRNLQIALNL SFNHLHGSLP PELGKLDKLV
460 470 480 490 500
SLDVSNNLLT GSIPPLLKGM MSLIEVNFSN NLLNGPVPVF VPFQKSPNSS
510 520 530 540 550
FLGNKELCGA PLSSSCGYSE DLDHLRYNHR VSYRIVLAVI GSGVAVFVSV
560 570 580 590 600
TVVVLLFMMR EKQEKAAAKN VDVEENVEDE QPAIIAGNVF LENLKQGIDL
610 620 630 640 650
DAVVKATMKE SNKLSTGTFS SVYKAVMPSG MIVSVKKLKS MDRAISHHQN
660 670 680 690 700
KMIRELERLS KLCHDHLVRP IGFVIYEDVA LLLHQHLPNG NLTQLIHEST
710 720 730 740 750
KKPEYQPDWP MRLSIAVGAA EGLAFLHQVA IIHLDVSSSN VLLDSGYKAV
760 770 780 790 800
LGEIEISKLL DPSRGTASIS SVAGSFGYIP PEYAYTMQVT APGNVYSYGV
810 820 830 840 850
VLLEILTSRA PVEEEFGEGV DLVKWVHGAS ARGETPEQIL DAKLSTVSFA
860 870 880 890
WRREMLAALK VALLCTDITP AKRPKMKKVV EMLQEVKQIK
Length:890
Mass (Da):97,245
Last modified:January 1, 1998 - v1
Checksum:iD43D2B4C848DA568
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401N → S in BAF00244 (Ref. 4) Curated
Sequence conflicti818 – 8181E → G in BAF00244 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002339 Genomic DNA. Translation: AAC02766.1.
CP002685 Genomic DNA. Translation: AEC10036.1.
FJ708712 mRNA. Translation: ACN59307.1.
AK228301 mRNA. Translation: BAF00244.1.
PIRiE84846.
RefSeqiNP_181713.1. NM_129746.2.
UniGeneiAt.43213.

Genome annotation databases

EnsemblPlantsiAT2G41820.1; AT2G41820.1; AT2G41820.
GeneIDi818781.
GrameneiAT2G41820.1; AT2G41820.1; AT2G41820.
KEGGiath:AT2G41820.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC
Arabidopsis protein tyrosine kinases

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002339 Genomic DNA. Translation: AAC02766.1.
CP002685 Genomic DNA. Translation: AEC10036.1.
FJ708712 mRNA. Translation: ACN59307.1.
AK228301 mRNA. Translation: BAF00244.1.
PIRiE84846.
RefSeqiNP_181713.1. NM_129746.2.
UniGeneiAt.43213.

3D structure databases

ProteinModelPortaliO22938.
SMRiO22938. Positions 19-488, 614-887.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4118. 58 interactions.
STRINGi3702.AT2G41820.1.

Proteomic databases

PaxDbiO22938.
PRIDEiO22938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G41820.1; AT2G41820.1; AT2G41820.
GeneIDi818781.
GrameneiAT2G41820.1; AT2G41820.1; AT2G41820.
KEGGiath:AT2G41820.

Organism-specific databases

TAIRiAT2G41820.

Phylogenomic databases

eggNOGiENOG410IHE1. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000116551.
InParanoidiO22938.
OMAiHEIGNCV.
PhylomeDBiO22938.

Enzyme and pathway databases

BioCyciARA:AT2G41820-MONOMER.

Miscellaneous databases

PROiO22938.

Gene expression databases

GenevisibleiO22938. AT.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR011009. Kinase-like_dom.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Genome-wide cloning and sequence analysis of leucine-rich repeat receptor-like protein kinase genes in Arabidopsis thaliana."
    Gou X., He K., Yang H., Yuan T., Lin H., Clouse S.D., Li J.
    BMC Genomics 11:19-19(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The Arabidopsis LRR-RLK, PXC1, is a regulator of secondary wall formation correlated with the TDIF-PXY/TDR-WOX4 signaling pathway."
    Wang J., Kucukoglu M., Zhang L., Chen P., Decker D., Nilsson O., Jones B., Sandberg G., Zheng B.
    BMC Plant Biol. 13:94-94(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiPXC3_ARATH
AccessioniPrimary (citable) accession number: O22938
Secondary accession number(s): Q0WRK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 1, 1998
Last modified: May 11, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.