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O22925

- VSR2_ARATH

UniProt

O22925 - VSR2_ARATH

Protein

Vacuolar-sorting receptor 2

Gene

VSR2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Vacuolar-sorting receptor (VSR) involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vacuolar-sorting receptor 2
    Short name:
    AtVSR2
    Alternative name(s):
    BP80-like protein c
    Short name:
    AtBP80c
    Epidermal growth factor receptor-like protein 4
    Short name:
    AtELP4
    Gene namesi
    Name:VSR2
    Synonyms:BP80C, ELP4
    Ordered Locus Names:At2g30290
    ORF Names:T9D9.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G30290.

    Subcellular locationi

    GO - Cellular componenti

    1. clathrin-coated vesicle membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. late endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 625606Vacuolar-sorting receptor 2PRO_0000036464Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi147 – 1471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi419 ↔ 437By similarity
    Disulfide bondi426 ↔ 446By similarity
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi448 ↔ 464By similarity
    Disulfide bondi472 ↔ 492By similarity
    Disulfide bondi479 ↔ 500By similarity
    Disulfide bondi502 ↔ 514By similarity
    Disulfide bondi544 ↔ 557By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiO22925.
    PRIDEiO22925.

    Expressioni

    Tissue specificityi

    Expressed only in flowers.1 Publication

    Gene expression databases

    ArrayExpressiO22925.
    GenevestigatoriO22925.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT2G30290.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliO22925.
    SMRiO22925. Positions 393-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 567548LumenalSequence AnalysisAdd
    BLAST
    Topological domaini589 – 62537CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei568 – 58821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini55 – 167113PAAdd
    BLAST
    Domaini415 – 46551EGF-like 1Add
    BLAST
    Domaini468 – 51548EGF-like 2Add
    BLAST
    Domaini516 – 55843EGF-like 3; calcium-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi608 – 6114Tyrosine-based internalization motifBy similarity

    Domaini

    The tyrosine-based internalization signal may be involved in trafficking at the TGN.By similarity

    Sequence similaritiesi

    Belongs to the VSR (BP-80) family.Curated
    Contains 3 EGF-like domains.Curated

    Keywords - Domaini

    EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG302407.
    HOGENOMiHOG000241019.
    InParanoidiO22925.
    PhylomeDBiO22925.

    Family and domain databases

    InterProiIPR001881. EGF-like_Ca-bd_dom.
    IPR018097. EGF_Ca-bd_CS.
    IPR003137. Protease-assoc_domain.
    [Graphical view]
    PfamiPF07645. EGF_CA. 1 hit.
    PF02225. PA. 1 hit.
    [Graphical view]
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS01187. EGF_CA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: O22925-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRTTNVWLVV IVWVTVGWSS CTGRFVVEKN NLRVTSPESI RGVYECALGN    50
    FGVPQYGGSM SGAVVYPKTN QKACKNFDDF EISFRSRVAG LPTFVLVDRG 100
    DCYFTLKAWN AQRAGAATIL VADNRPEQLI TMDAPEDETS DADYLQNITI 150
    PSALVSRSLG SAIKTAIAHG DPVHISLDWR EALPHPNDRV AYELWTNSND 200
    ECGSKCDAQI RFLKRFKGAA QILEKGGYTR FTPHYITWYC PEAFLASRQC 250
    KTQCINGGRY CAPDPEQDFS RGYNGKDVII QNLRQACFFR VTNESGKPWL 300
    WWDYVTDFAI RCPMKEEKYN KKCADQVIQS LGVDVKKIDK CIGDIDANAE 350
    NPVLKEEQVA QVGKGSRGDV TILPTIVINN RQYRGKLQRS AVLKALCSGF 400
    RETTEPPICL TEDIETNECL QNNGGCWEDK TTNITACRDT FRGRVCQCPI 450
    VQGVKFLGDG YTHCEASGAL RCGINNGGCW KQTQMGKTYS ACRDDHSKGC 500
    KCPPGFIGDG LKECKDVNEC EEKTACQCRD CKCKNTWGSY ECSCSGSLLY 550
    IREHDICINR DARGDFSWGV IWIIIMGLGA AALGAYTVYK YRIRTYMDSE 600
    IRAIMAQYMP LDNNPNTQLS SQLEL 625
    Length:625
    Mass (Da):69,875
    Last modified:January 1, 1998 - v1
    Checksum:i008F9E254ADDCE5C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002338 Genomic DNA. Translation: AAC16948.1.
    CP002685 Genomic DNA. Translation: AEC08366.1.
    DQ446580 mRNA. Translation: ABE65874.1.
    PIRiF84706.
    RefSeqiNP_180588.1. NM_128582.1. [O22925-1]
    UniGeneiAt.52975.

    Genome annotation databases

    EnsemblPlantsiAT2G30290.1; AT2G30290.1; AT2G30290. [O22925-1]
    AT2G30290.2; AT2G30290.2; AT2G30290.
    GeneIDi817579.
    KEGGiath:AT2G30290.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002338 Genomic DNA. Translation: AAC16948.1 .
    CP002685 Genomic DNA. Translation: AEC08366.1 .
    DQ446580 mRNA. Translation: ABE65874.1 .
    PIRi F84706.
    RefSeqi NP_180588.1. NM_128582.1. [O22925-1 ]
    UniGenei At.52975.

    3D structure databases

    ProteinModelPortali O22925.
    SMRi O22925. Positions 393-549.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT2G30290.1-P.

    Proteomic databases

    PaxDbi O22925.
    PRIDEi O22925.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G30290.1 ; AT2G30290.1 ; AT2G30290 . [O22925-1 ]
    AT2G30290.2 ; AT2G30290.2 ; AT2G30290 .
    GeneIDi 817579.
    KEGGi ath:AT2G30290.

    Organism-specific databases

    TAIRi AT2G30290.

    Phylogenomic databases

    eggNOGi NOG302407.
    HOGENOMi HOG000241019.
    InParanoidi O22925.
    PhylomeDBi O22925.

    Gene expression databases

    ArrayExpressi O22925.
    Genevestigatori O22925.

    Family and domain databases

    InterProi IPR001881. EGF-like_Ca-bd_dom.
    IPR018097. EGF_Ca-bd_CS.
    IPR003137. Protease-assoc_domain.
    [Graphical view ]
    Pfami PF07645. EGF_CA. 1 hit.
    PF02225. PA. 1 hit.
    [Graphical view ]
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS01187. EGF_CA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
      Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
      Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Seed germination is blocked in Arabidopsis putative vacuolar sorting receptor (atbp80) antisense transformants."
      Laval V., Masclaux F., Serin A., Carriere M., Roldan C., Devic M., Pont-Lezica R.F., Galaud J.-P.
      J. Exp. Bot. 54:213-221(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. "Vacuolar sorting receptor for seed storage proteins in Arabidopsis thaliana."
      Shimada T., Fuji K., Tamura K., Kondo M., Nishimura M., Hara-Nishimura I.
      Proc. Natl. Acad. Sci. U.S.A. 100:16095-16100(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiVSR2_ARATH
    AccessioniPrimary (citable) accession number: O22925
    Secondary accession number(s): Q1PEY7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3