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O22925

- VSR2_ARATH

UniProt

O22925 - VSR2_ARATH

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Protein
Vacuolar-sorting receptor 2
Gene
VSR2, BP80C, ELP4, At2g30290, T9D9.10
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Vacuolar-sorting receptor (VSR) involved in clathrin-coated vesicles sorting from Golgi apparatus to vacuoles By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar-sorting receptor 2
Short name:
AtVSR2
Alternative name(s):
BP80-like protein c
Short name:
AtBP80c
Epidermal growth factor receptor-like protein 4
Short name:
AtELP4
Gene namesi
Name:VSR2
Synonyms:BP80C, ELP4
Ordered Locus Names:At2g30290
ORF Names:T9D9.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G30290.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 567548Lumenal Reviewed prediction
Add
BLAST
Transmembranei568 – 58821Helical; Reviewed prediction
Add
BLAST
Topological domaini589 – 62537Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. clathrin-coated vesicle membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 625606Vacuolar-sorting receptor 2
PRO_0000036464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi147 – 1471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi293 – 2931N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi419 ↔ 437 By similarity
Disulfide bondi426 ↔ 446 By similarity
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi448 ↔ 464 By similarity
Disulfide bondi472 ↔ 492 By similarity
Disulfide bondi479 ↔ 500 By similarity
Disulfide bondi502 ↔ 514 By similarity
Disulfide bondi544 ↔ 557 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO22925.
PRIDEiO22925.

Expressioni

Tissue specificityi

Expressed only in flowers.1 Publication

Gene expression databases

ArrayExpressiO22925.
GenevestigatoriO22925.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G30290.1-P.

Structurei

3D structure databases

ProteinModelPortaliO22925.
SMRiO22925. Positions 393-549.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 167113PA
Add
BLAST
Domaini415 – 46551EGF-like 1
Add
BLAST
Domaini468 – 51548EGF-like 2
Add
BLAST
Domaini516 – 55843EGF-like 3; calcium-binding Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi608 – 6114Tyrosine-based internalization motif By similarity

Domaini

The tyrosine-based internalization signal may be involved in trafficking at the TGN By similarity.

Sequence similaritiesi

Belongs to the VSR (BP-80) family.
Contains 3 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG302407.
HOGENOMiHOG000241019.
InParanoidiO22925.
PhylomeDBiO22925.

Family and domain databases

InterProiIPR001881. EGF-like_Ca-bd_dom.
IPR018097. EGF_Ca-bd_CS.
IPR003137. Protease-assoc_domain.
[Graphical view]
PfamiPF07645. EGF_CA. 1 hit.
PF02225. PA. 1 hit.
[Graphical view]
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS01187. EGF_CA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: O22925-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRTTNVWLVV IVWVTVGWSS CTGRFVVEKN NLRVTSPESI RGVYECALGN    50
FGVPQYGGSM SGAVVYPKTN QKACKNFDDF EISFRSRVAG LPTFVLVDRG 100
DCYFTLKAWN AQRAGAATIL VADNRPEQLI TMDAPEDETS DADYLQNITI 150
PSALVSRSLG SAIKTAIAHG DPVHISLDWR EALPHPNDRV AYELWTNSND 200
ECGSKCDAQI RFLKRFKGAA QILEKGGYTR FTPHYITWYC PEAFLASRQC 250
KTQCINGGRY CAPDPEQDFS RGYNGKDVII QNLRQACFFR VTNESGKPWL 300
WWDYVTDFAI RCPMKEEKYN KKCADQVIQS LGVDVKKIDK CIGDIDANAE 350
NPVLKEEQVA QVGKGSRGDV TILPTIVINN RQYRGKLQRS AVLKALCSGF 400
RETTEPPICL TEDIETNECL QNNGGCWEDK TTNITACRDT FRGRVCQCPI 450
VQGVKFLGDG YTHCEASGAL RCGINNGGCW KQTQMGKTYS ACRDDHSKGC 500
KCPPGFIGDG LKECKDVNEC EEKTACQCRD CKCKNTWGSY ECSCSGSLLY 550
IREHDICINR DARGDFSWGV IWIIIMGLGA AALGAYTVYK YRIRTYMDSE 600
IRAIMAQYMP LDNNPNTQLS SQLEL 625
Length:625
Mass (Da):69,875
Last modified:January 1, 1998 - v1
Checksum:i008F9E254ADDCE5C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002338 Genomic DNA. Translation: AAC16948.1.
CP002685 Genomic DNA. Translation: AEC08366.1.
DQ446580 mRNA. Translation: ABE65874.1.
PIRiF84706.
RefSeqiNP_180588.1. NM_128582.1. [O22925-1]
UniGeneiAt.52975.

Genome annotation databases

EnsemblPlantsiAT2G30290.1; AT2G30290.1; AT2G30290. [O22925-1]
AT2G30290.2; AT2G30290.2; AT2G30290.
GeneIDi817579.
KEGGiath:AT2G30290.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC002338 Genomic DNA. Translation: AAC16948.1 .
CP002685 Genomic DNA. Translation: AEC08366.1 .
DQ446580 mRNA. Translation: ABE65874.1 .
PIRi F84706.
RefSeqi NP_180588.1. NM_128582.1. [O22925-1 ]
UniGenei At.52975.

3D structure databases

ProteinModelPortali O22925.
SMRi O22925. Positions 393-549.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT2G30290.1-P.

Proteomic databases

PaxDbi O22925.
PRIDEi O22925.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G30290.1 ; AT2G30290.1 ; AT2G30290 . [O22925-1 ]
AT2G30290.2 ; AT2G30290.2 ; AT2G30290 .
GeneIDi 817579.
KEGGi ath:AT2G30290.

Organism-specific databases

TAIRi AT2G30290.

Phylogenomic databases

eggNOGi NOG302407.
HOGENOMi HOG000241019.
InParanoidi O22925.
PhylomeDBi O22925.

Gene expression databases

ArrayExpressi O22925.
Genevestigatori O22925.

Family and domain databases

InterProi IPR001881. EGF-like_Ca-bd_dom.
IPR018097. EGF_Ca-bd_CS.
IPR003137. Protease-assoc_domain.
[Graphical view ]
Pfami PF07645. EGF_CA. 1 hit.
PF02225. PA. 1 hit.
[Graphical view ]
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS01186. EGF_2. 1 hit.
PS01187. EGF_CA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Simultaneous high-throughput recombinational cloning of open reading frames in closed and open configurations."
    Underwood B.A., Vanderhaeghen R., Whitford R., Town C.D., Hilson P.
    Plant Biotechnol. J. 4:317-324(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Seed germination is blocked in Arabidopsis putative vacuolar sorting receptor (atbp80) antisense transformants."
    Laval V., Masclaux F., Serin A., Carriere M., Roldan C., Devic M., Pont-Lezica R.F., Galaud J.-P.
    J. Exp. Bot. 54:213-221(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. "Vacuolar sorting receptor for seed storage proteins in Arabidopsis thaliana."
    Shimada T., Fuji K., Tamura K., Kondo M., Nishimura M., Hara-Nishimura I.
    Proc. Natl. Acad. Sci. U.S.A. 100:16095-16100(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiVSR2_ARATH
AccessioniPrimary (citable) accession number: O22925
Secondary accession number(s): Q1PEY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: January 1, 1998
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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