O22886 (DCUP2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen decarboxylase 2, chloroplastic
Short name=UPD2
Short name=URO-D2
EC=4.1.1.37

Gene names

Ordered Locus Names:	At2g40490
ORF Names:	T2P4.16

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	394 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2.
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.
Subunit structure	Homodimer By similarity.
Subcellular location	Plastid › chloroplast Potential.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Porphyrin biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast envelope Inferred from direct assay. Source: TAIR chloroplast stroma Inferred from direct assay. Source: TAIR
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Chloroplast Potential
	Chain	? – 394		Uroporphyrinogen decarboxylase 2, chloroplastic		PRO_0000036329
Regions
	Region	74 – 78	5	Substrate binding By similarity
Sites
	Binding site	93	1	Substrate By similarity
	Binding site	123	1	Substrate By similarity
	Binding site	124	1	Substrate By similarity
	Binding site	201	1	Substrate By similarity
	Binding site	256	1	Substrate By similarity
	Binding site	371	1	Substrate By similarity
	Site	124	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	O22886 [UniParc]. Last modified January 1, 1998. Version 1. Checksum: B97992D4EE1AD9A7	FASTA	394	43,580
	10 20 30 40 50 60 MSILQVSTSS LSSSTLLSIS PRKSLSSTKS CRIVRCSVEG TTVTERKVSA TSEPLLLRAV 70 80 90 100 110 120 KGEVVDRPPV WLMRQAGRYM KSYQTLCEKY PSFRDRSENA DLVVEISLQP WKVFKPDGVI 130 140 150 160 170 180 LFSDILTPLS GMNIPFDIVK GKGPIIFNPP QSAADVAQVR EFVPEESVPY VGEALRRLRN 190 200 210 220 230 240 EVNNEAAVLG FVGAPFTLSS YVIEGGSSKN FTQIKRLAFS QPKVLHALLQ KFTTSMITYI 250 260 270 280 290 300 RYQADSGAQA VQIFDSWATE LSPVDFEEFS LPYLKQIVEA VKQTHPNLPL ILYASGSGGL 310 320 330 340 350 360 LERLARTGVD VVSLDWTVDM AEGRDRLGRD IAVQGNVDPG VLFGSKEFIT SRIHDTVKKA 370 380 390 GRDKHILNLG HGIKVGTPEE NVAHFFEVAQ EIRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002336 Genomic DNA. Translation: AAB87587.1. CP002685 Genomic DNA. Translation: AEC09837.1. AY142634 mRNA. Translation: AAN13092.1.
IPI	IPI00540037.
PIR	B84830.
RefSeq	NP_181581.1. NM_129611.4.
UniGene	At.12206.
3D structure databases
ProteinModelPortal	O22886.
SMR	O22886. Positions 52-394.
ModBase	Search...
Protein-protein interaction databases
STRING	O22886.
Proteomic databases
PRIDE	O22886.
ProMEX	O22886.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G40490.1; AT2G40490.1; AT2G40490.
GeneID	818644.
GenomeReviews	Gene locus AT2G40490 in contig CT485783_GR.
KEGG	ath:AT2G40490.
NMPDR	fig|3702.1.peg.11182.
Organism-specific databases
TAIR	At2g40490.
Phylogenomic databases
eggNOG	KOG2872.
HOGENOM	HBG628392.
InParanoid	O22886.
OMA	GMNIPFD.
PhylomeDB	O22886.
ProtClustDB	PLN02433.
Gene expression databases
Genevestigator	O22886.
GermOnline	AT2G40490. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
KO	K01599.
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
TIGRFAMs	TIGR01464. HemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP2_ARATH

Accession

Primary (citable) accession number: O22886

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 1, 1998
Last modified:	November 16, 2011
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program