Reviewed, UniProtKB/Swiss-Prot O22870 (FKBP2_ARATH)

Names and origin

Protein names

Recommended name:
    Probable FKBP-type peptidyl-prolyl cis-trans isomerase 2, chloroplastic
      Short name=PPIase
      Short name=Rotamase
    EC=5.2.1.8

Gene names

Ordered Locus Names:	At2g43560
ORF Names:	T1O24.30

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Plastid › chloroplast thylakoid lumen. Ref.3
Sequence similarities	Belongs to the FKBP-type PPIase family. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Chloroplast Plastid Thylakoid
Domain	Transit peptide
Molecular function	Isomerase Rotamase
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	protein folding Non-traceable author statement. Source: UniProtKB
Cellular component	chloroplast thylakoid lumen Ref.3 Inferred from direct assay. Source: UniProtKB
Molecular function	peptidyl-prolyl cis-trans isomerase activity Non-traceable author statement. Source: UniProtKB protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TRX3	Q42403	1	EBI-449404,EBI-449157

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 36	36	Chloroplast Potential
	Transit peptide	37 – 77	41	Thylakoid
	Chain	78 – 223	146	Probable FKBP-type peptidyl-prolyl cis-trans isomerase 2, chloroplastic		PRO_0000025525
Regions
	Domain	124 – 216	93	PPIase FKBP-type

Sequences

	Sequence		Length	Mass (Da)
	O22870-1 [UniParc]. Last modified March 27, 2002. Version 2. Checksum: BE3A48D0C1A59C38	FASTA	223	23,564
	10 20 30 40 50 60 MAASSPSLLL PLGSASRNGL TTKNPNSSRY IAARVIASET REQSCKISNL SSRREAMLLV 70 80 90 100 110 120 LGVSGGLSMS SLAAYAAGLP PEDKPRLCEA ECEKELENVP MVTTESGLQY KDIKVGRGPS 130 140 150 160 170 180 PPVGFQVAAN YVAMVPSGQI FDSSLEKGLP YLFRVGSGQV IKGLDEGILS MKAGGKRRLY 190 200 210 220 IPGPLAFPKG LVSAPGRPRV APNSPVIFDV SLEFIPGLDS EEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Proteome map of the chloroplast lumen of Arabidopsis thaliana." Schubert M., Petersson U.A., Haas B.J., Funk C., Schroeder W.P., Kieselbach T. J. Biol. Chem. 277:8354-8365(2002) [PubMed: 11719511] [Abstract] Cited for: PROTEIN SEQUENCE OF 77-96, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC002335 Genomic DNA. Translation: AAB64339.2. AY056125 mRNA. Translation: AAL07204.1. AY113988 mRNA. Translation: AAM45036.1.
IPI	IPI00531720.
PIR	F84867.
RefSeq	NP_181884.1.
UniGene	At.24392
3D structure databases
HSSP	HSSP built from PDB template 1YAT based on UniProtKB P20081.
ModBase	Search...
Protein-protein interaction databases
IntAct	O22870. 1 interaction.
Proteomic databases
PRIDE	O22870.
ProMEX	O22870.
Genome annotation databases
GeneID	818958.
GenomeReviews	Gene locus AT2G43560 in contig CT485783_GR.
KEGG	ath:AT2G43560.
NMPDR	fig|3702.1.peg.11513.
Organism-specific databases
TAIR	At2g43560.
Phylogenomic databases
OMA	O22870. LYIFRVG.
Enzyme and pathway databases
BRENDA	5.2.1.8. 302.
Gene expression databases
ArrayExpress	O22870.
GermOnline	AT2G43560. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00254. FKBP_C. 1 hit. [Graphical view]
PROSITE	PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FKBP2_ARATH

Accession

Primary (citable) accession number: O22870
Secondary accession number(s): Q940C0

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	March 27, 2002
Last modified:	May 5, 2009
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)