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Protein

Probable peroxidase 26

Gene

PER26

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress (Probable). The enzyme activity has to be proved.Curated

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Caution

Lacks the distal histidine (here Ser-77), present in the active site, which is one of the conserved features of the classical plant (class III) peroxidase family.Curated

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei73By similarity1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi81Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi83Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi85Calcium 1PROSITE-ProRule annotation1
Metal bindingi87Calcium 1PROSITE-ProRule annotation1
Binding sitei168Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi198Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi199Calcium 2PROSITE-ProRule annotation1
Metal bindingi255Calcium 2PROSITE-ProRule annotation1
Metal bindingi258Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G43480-MONOMER

Protein family/group databases

PeroxiBasei119 AtPrx26

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peroxidase 26 (EC:1.11.1.7)
Short name:
Atperox P26
Alternative name(s):
ATP50
Gene namesi
Name:PER26
Synonyms:P26
Ordered Locus Names:At2g43480
ORF Names:T1O24.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G43480
TAIRilocus:2058208 AT2G43480

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002369219 – 335Probable peroxidase 26Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 122PROSITE-ProRule annotation
Disulfide bondi79 ↔ 84PROSITE-ProRule annotation
Disulfide bondi128 ↔ 331PROSITE-ProRule annotation
Disulfide bondi205 ↔ 237PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO22862
PRIDEiO22862

Expressioni

Gene expression databases

ExpressionAtlasiO22862 baseline and differential
GenevisibleiO22862 AT

Interactioni

Protein-protein interaction databases

BioGridi4285, 1 interactor
STRINGi3702.AT2G43480.1

Structurei

3D structure databases

ProteinModelPortaliO22862
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG0P Eukaryota
ENOG410YECP LUCA
HOGENOMiHOG000237556
InParanoidiO22862
KOiK00430
OMAiMIHIFLT
OrthoDBiEOG09360EAJ
PhylomeDBiO22862

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22862-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVMIHIFLTV MVVGGVSLFP ETAEAIVMGP SMQKLTWHYY KVYNTCENAE
60 70 80 90 100
NFVRHQVEIF YKNDKSIAPK LLRLLYSDCF VSGCDASVLL EGPNSEKMAP
110 120 130 140 150
QNRGLGGFVL IDKIKIVLEQ RCPGVVSCAD ILNLATRDAV HLAGAPSYPV
160 170 180 190 200
FTGRRDGLTS DKQTVDLPSP SISWDQAMSY FKSRGLNVLD MATLLGSHSM
210 220 230 240 250
GRTHCSYVVD RLYNYNKTGK PSPTMNKYFL SEMAKQCPPR TRKGQTDPLV
260 270 280 290 300
YLNPDSGSNH SFTSSFYSRI LSNKSVLEVD QQLLYNDDTK QISKEFSEGF
310 320 330
EDFRKSFALS MSKMGAINVL TKTEGEIRKD CRHIN
Length:335
Mass (Da):37,568
Last modified:November 25, 2002 - v2
Checksum:iCAF4B893D9C3CC24
GO

Sequence cautioni

The sequence AAB64327 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140V → I in AAL84934 (PubMed:14593172).Curated1
Sequence conflicti189L → R in AAL84934 (PubMed:14593172).Curated1
Sequence conflicti208V → A in AAL84934 (PubMed:14593172).Curated1
Sequence conflicti286N → D in AAL84934 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002335 Genomic DNA Translation: AAB64327.1 Different initiation.
CP002685 Genomic DNA Translation: AEC10275.1
AY078928 mRNA Translation: AAL84934.1
RefSeqiNP_181876.2, NM_129909.3

Genome annotation databases

EnsemblPlantsiAT2G43480.1; AT2G43480.1; AT2G43480
GeneIDi818949
GrameneiAT2G43480.1; AT2G43480.1; AT2G43480
KEGGiath:AT2G43480

Similar proteinsi

Entry informationi

Entry nameiPER26_ARATH
AccessioniPrimary (citable) accession number: O22862
Secondary accession number(s): Q8RY36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: April 25, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health