Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Calmodulin-like protein 5

Gene

CML5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium sensor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi74 – 85121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi110 – 121122PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi152 – 163123PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi190 – 201124PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 5
Alternative name(s):
Protein MULTICOPY SUPPRESSORS OF SNF4 DEFICIENCY IN YEAST 3
Gene namesi
Name:CML5
Synonyms:MSS3
Ordered Locus Names:At2g43290
ORF Names:F14B2.33, T1O24.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G43290.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: TAIR
  • integral component of endosome membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Calmodulin-like protein 5PRO_0000342888Add
BLAST

Proteomic databases

PaxDbiO22845.
PRIDEiO22845.

Expressioni

Inductioni

By touch and during darkness conditions.1 Publication

Gene expression databases

GenevisibleiO22845. AT.

Interactioni

Protein-protein interaction databases

BioGridi4268. 3 interactions.
STRINGi3702.AT2G43290.1.

Structurei

3D structure databases

ProteinModelPortaliO22845.
SMRiO22845. Positions 63-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 9636EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini97 – 13236EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini139 – 17436EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini177 – 21236EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 556Poly-Ser

Sequence similaritiesi

Belongs to the calmodulin family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiO22845.
KOiK13448.
OMAiGMIDFQE.
PhylomeDBiO22845.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

O22845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRIFLLYNI LNSFLLSLVP KKLRTLFPLS WFDKTLHKNS PPSPSTMLPS
60 70 80 90 100
PSSSSAPTKR IDPSELKRVF QMFDKNGDGR ITKEELNDSL ENLGIYIPDK
110 120 130 140 150
DLTQMIHKID ANGDGCVDID EFESLYSSIV DEHHNDGETE EEDMKDAFNV
160 170 180 190 200
FDQDGDGFIT VEELKSVMAS LGLKQGKTLD GCKKMIMQVD ADGDGRVNYK
210
EFLQMMKGGG FSSSN
Length:215
Mass (Da):24,114
Last modified:June 1, 2002 - v2
Checksum:iA225E5A6E70D96C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250344 mRNA. Translation: AAG10150.1.
AC002335 Genomic DNA. Translation: AAB64310.2.
AC004450 Genomic DNA. Translation: AAM14938.1.
CP002685 Genomic DNA. Translation: AEC10248.1.
AY062815 mRNA. Translation: AAL32893.1.
AY081574 mRNA. Translation: AAM10136.1.
AY087087 mRNA. Translation: AAM64648.1.
PIRiD84864.
RefSeqiNP_565996.1. NM_129891.2.
UniGeneiAt.21047.

Genome annotation databases

EnsemblPlantsiAT2G43290.1; AT2G43290.1; AT2G43290.
GeneIDi818931.
GrameneiAT2G43290.1; AT2G43290.1; AT2G43290.
KEGGiath:AT2G43290.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250344 mRNA. Translation: AAG10150.1.
AC002335 Genomic DNA. Translation: AAB64310.2.
AC004450 Genomic DNA. Translation: AAM14938.1.
CP002685 Genomic DNA. Translation: AEC10248.1.
AY062815 mRNA. Translation: AAL32893.1.
AY081574 mRNA. Translation: AAM10136.1.
AY087087 mRNA. Translation: AAM64648.1.
PIRiD84864.
RefSeqiNP_565996.1. NM_129891.2.
UniGeneiAt.21047.

3D structure databases

ProteinModelPortaliO22845.
SMRiO22845. Positions 63-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4268. 3 interactions.
STRINGi3702.AT2G43290.1.

Proteomic databases

PaxDbiO22845.
PRIDEiO22845.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G43290.1; AT2G43290.1; AT2G43290.
GeneIDi818931.
GrameneiAT2G43290.1; AT2G43290.1; AT2G43290.
KEGGiath:AT2G43290.

Organism-specific databases

TAIRiAT2G43290.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiO22845.
KOiK13448.
OMAiGMIDFQE.
PhylomeDBiO22845.

Miscellaneous databases

PROiO22845.

Gene expression databases

GenevisibleiO22845. AT.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Functional identification of an Arabidopsis Snf4 ortholog by screening for heterologous multicopy suppressors of snf4 deficiency in yeast."
    Kleinow T., Bhalerao R., Breuer F., Umeda M., Salchert K., Koncz C.
    Plant J. 23:115-122(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Columbia.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Calmodulins and related potential calcium sensors of Arabidopsis."
    McCormack E., Braam J.
    New Phytol. 159:585-598(2003)
    Cited for: GENE FAMILY, NOMENCLATURE.
  7. "Genome-wide identification of touch- and darkness-regulated Arabidopsis genes: a focus on calmodulin-like and XTH genes."
    Lee D., Polisensky D.H., Braam J.
    New Phytol. 165:429-444(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCML5_ARATH
AccessioniPrimary (citable) accession number: O22845
Secondary accession number(s): Q9FV55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2002
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.