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Protein

Calmodulin-like protein 5

Gene

CML5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potential calcium sensor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi74 – 851PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi110 – 1212PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi152 – 1633PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi190 – 2014PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calmodulin-like protein 5
Alternative name(s):
Protein MULTICOPY SUPPRESSORS OF SNF4 DEFICIENCY IN YEAST 3
Gene namesi
Name:CML5
Synonyms:MSS3
Ordered Locus Names:At2g43290
ORF Names:F14B2.33, T1O24.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G43290.
TAIRilocus:2058198. AT2G43290.

Subcellular locationi

GO - Cellular componenti

  • endomembrane system Source: TAIR
  • integral component of endosome membrane Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003428881 – 215Calmodulin-like protein 5Add BLAST215

Proteomic databases

PaxDbiO22845.

Expressioni

Inductioni

By touch and during darkness conditions.1 Publication

Gene expression databases

ExpressionAtlasiO22845. baseline and differential.
GenevisibleiO22845. AT.

Interactioni

Protein-protein interaction databases

BioGridi4268. 3 interactors.
STRINGi3702.AT2G43290.1.

Structurei

3D structure databases

ProteinModelPortaliO22845.
SMRiO22845.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 96EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini97 – 132EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini139 – 174EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini177 – 212EF-hand 4PROSITE-ProRule annotationAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 55Poly-Ser6

Sequence similaritiesi

Belongs to the calmodulin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
HOGENOMiHOG000233018.
InParanoidiO22845.
KOiK13448.
OMAiIVDEHHN.
OrthoDBiEOG09360QFU.
PhylomeDBiO22845.

Family and domain databases

CDDicd00051. EFh. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
PfamiView protein in Pfam
PF13499. EF-hand_7. 2 hits.
SMARTiView protein in SMART
SM00054. EFh. 4 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.

Sequencei

Sequence statusi: Complete.

O22845-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRIFLLYNI LNSFLLSLVP KKLRTLFPLS WFDKTLHKNS PPSPSTMLPS
60 70 80 90 100
PSSSSAPTKR IDPSELKRVF QMFDKNGDGR ITKEELNDSL ENLGIYIPDK
110 120 130 140 150
DLTQMIHKID ANGDGCVDID EFESLYSSIV DEHHNDGETE EEDMKDAFNV
160 170 180 190 200
FDQDGDGFIT VEELKSVMAS LGLKQGKTLD GCKKMIMQVD ADGDGRVNYK
210
EFLQMMKGGG FSSSN
Length:215
Mass (Da):24,114
Last modified:June 1, 2002 - v2
Checksum:iA225E5A6E70D96C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF250344 mRNA. Translation: AAG10150.1.
AC002335 Genomic DNA. Translation: AAB64310.2.
AC004450 Genomic DNA. Translation: AAM14938.1.
CP002685 Genomic DNA. Translation: AEC10248.1.
AY062815 mRNA. Translation: AAL32893.1.
AY081574 mRNA. Translation: AAM10136.1.
AY087087 mRNA. Translation: AAM64648.1.
PIRiD84864.
RefSeqiNP_565996.1. NM_129891.2.
UniGeneiAt.21047.

Genome annotation databases

EnsemblPlantsiAT2G43290.1; AT2G43290.1; AT2G43290.
GeneIDi818931.
GrameneiAT2G43290.1; AT2G43290.1; AT2G43290.
KEGGiath:AT2G43290.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCML5_ARATH
AccessioniPrimary (citable) accession number: O22845
Secondary accession number(s): Q9FV55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 1, 2002
Last modified: June 7, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families