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Protein

L-type lectin-domain containing receptor kinase V.4

Gene

LECRK54

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei363 – 3631ATPPROSITE-ProRule annotation
Active sitei460 – 4601Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi340 – 3489ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. carbohydrate binding Source: UniProtKB-KW
  3. peptide receptor activity Source: GO_Central
  4. transmembrane receptor protein serine/threonine kinase activity Source: GO_Central
  5. ubiquitin protein ligase binding Source: GO_Central

GO - Biological processi

  1. hormone-mediated signaling pathway Source: GO_Central
  2. protein autophosphorylation Source: GO_Central
  3. transmembrane receptor protein serine/threonine kinase signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Lectin, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G43700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
L-type lectin-domain containing receptor kinase V.4 (EC:2.7.11.1)
Short name:
Arabidopsis thaliana lectin-receptor kinase c1
Short name:
AthlecRK-c1
Short name:
LecRK-V.4
Gene namesi
Name:LECRK54
Synonyms:LECRKC1
Ordered Locus Names:At2g43700
ORF Names:F18O19.19
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G43700.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 280255ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Topological domaini302 – 658357CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
  3. plasmodesma Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 658633L-type lectin-domain containing receptor kinase V.4PRO_0000403092Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi196 – 1961N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO22833.
PRIDEiO22833.

Expressioni

Gene expression databases

GenevestigatoriO22833.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G43700.1-P.

Structurei

3D structure databases

ProteinModelPortaliO22833.
SMRiO22833. Positions 46-247, 267-613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 592259Protein kinasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni26 – 248223Legume-lectin likeAdd
BLAST

Sequence similaritiesi

In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.Curated
In the N-terminal section; belongs to the leguminous lectin family.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116555.
InParanoidiO22833.
OMAiNSANDTV.
PhylomeDBiO22833.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001220. Legume_lectin_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIGSRVI FLILALFCCT ENSRGKLVMQ GSAGFFKGYR TLTSTKKHAY
60 70 80 90 100
GQAFEDEIVP FKNSANDTVT SFSVTFFFAI APEDKHKGAH GMAFVISPTR
110 120 130 140 150
GITGASADQY LGIFNKANNG DSSNHVIAVE LDINKDEEFG DINDNHVGIN
160 170 180 190 200
INGMRSIKFA PAGYYDQEGQ FKDLSLISGS LLRVTILYSQ MEKQLNVTLS
210 220 230 240 250
SPEEAYYPNK PLLSLNQDLS PYILENMYVG FSASTGSVRA MHYMLSWFVH
260 270 280 290 300
GGVDVPNLDL GIPTFPPYPK EKSLVYRIVL VTSLALVLFV ALVASALSIF
310 320 330 340 350
FYRRHKKVKE VLEEWEIQCG PHRFAYKELF KATKGFKQLL GKGGFGQVFK
360 370 380 390 400
GTLPGSDAEI AVKRISHDSK QGMQEFLAEI STIGRLRHQN LVRLQGYCRY
410 420 430 440 450
KEELYLVYDF MPNGSLDKYL YHRANQEQLT WNQRFKIIKD IASALCYLHH
460 470 480 490 500
EWVQVVIHRD IKPANVLIDH QMNARLGDFG LAKLYDQGYD PQTSRVAGTF
510 520 530 540 550
WYIAPELIRS GRATTGTDVY AFGLFMLEVS CGRRLIERRT ASDEVVLAEW
560 570 580 590 600
TLKCWENGDI LEAVNDGIRH EDNREQLELV LKLGVLCSHQ AVAIRPDMSK
610 620 630 640 650
VVQILGGDLQ LPDNLLDIVK AEKVRMWSET SESVLGVLTS QGSIGTLTLT

EPFTSRGR
Length:658
Mass (Da):73,906
Last modified:January 1, 1998 - v1
Checksum:i66E871108F732BB1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002333 Genomic DNA. Translation: AAB64036.1.
CP002685 Genomic DNA. Translation: AEC10309.1.
AY074631 mRNA. Translation: AAL69447.1.
PIRiD84869.
RefSeqiNP_181898.1. NM_129932.6.
UniGeneiAt.37031.

Genome annotation databases

EnsemblPlantsiAT2G43700.1; AT2G43700.1; AT2G43700.
GeneIDi818972.
KEGGiath:AT2G43700.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002333 Genomic DNA. Translation: AAB64036.1.
CP002685 Genomic DNA. Translation: AEC10309.1.
AY074631 mRNA. Translation: AAL69447.1.
PIRiD84869.
RefSeqiNP_181898.1. NM_129932.6.
UniGeneiAt.37031.

3D structure databases

ProteinModelPortaliO22833.
SMRiO22833. Positions 46-247, 267-613.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G43700.1-P.

Proteomic databases

PaxDbiO22833.
PRIDEiO22833.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G43700.1; AT2G43700.1; AT2G43700.
GeneIDi818972.
KEGGiath:AT2G43700.

Organism-specific databases

GeneFarmi92. 4.
TAIRiAT2G43700.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116555.
InParanoidiO22833.
OMAiNSANDTV.
PhylomeDBiO22833.

Enzyme and pathway databases

BioCyciARA:AT2G43700-MONOMER.

Miscellaneous databases

PROiO22833.

Gene expression databases

GenevestigatoriO22833.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR011009. Kinase-like_dom.
IPR001220. Legume_lectin_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00139. Lectin_legB. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Characterization of the Arabidopsis lecRK-a genes: members of a superfamily encoding putative receptors with an extracellular domain homologous to legume lectins."
    Herve C., Serres J., Dabos P., Canut H., Barre A., Rouge P., Lescure B.
    Plant Mol. Biol. 39:671-682(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  5. Cited for: GENE FAMILY.
  6. "Arabidopsis L-type lectin receptor kinases: phylogeny, classification, and expression profiles."
    Bouwmeester K., Govers F.
    J. Exp. Bot. 60:4383-4396(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLRK54_ARATH
AccessioniPrimary (citable) accession number: O22833
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 1, 1998
Last modified: April 29, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.